(27 nodes) p53-Independent G1/S DNA damage checkpoint network (Trypanosoma cruzi)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Q4D6T6_TRYCC	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (311 aa)
	Q4CT97_TRYCC	Protein kinase, putative. (687 aa)
	Q4CUA3_TRYCC	Protein kinase, putative; Belongs to the protein kinase superfamily. (415 aa)
	Q4CX04_TRYCC	Ubiquitin/ribosomal protein S27a, putative. (209 aa)
	Q4CXN0_TRYCC	Ubiquitin/ribosomal protein S27a, putative. (211 aa)
	Q4DMM6_TRYCC	Protein kinase, putative; Belongs to the protein kinase superfamily. (346 aa)
	Q4DPH9_TRYCC	Uncharacterized protein. (1848 aa)
	Q4DSQ4_TRYCC	Ubiquitin/ribosomal protein S27a, putative. (150 aa)
	Q4DW25_TRYCC	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (284 aa)
	Q4DXC0_TRYCC	Proteasome regulatory non-ATPase subunit 2, putative; Belongs to the proteasome subunit S1 family. (961 aa)
	Q4DZU2_TRYCC	Protein kinase, putative. (1369 aa)
	Q4E0L9_TRYCC	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (284 aa)
	Q4E1J8_TRYCC	Protein kinase, putative. (834 aa)
	Q4E4R6_TRYCC	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (302 aa)
	Q4DL76_TRYCC	Protein kinase, putative. (545 aa)
	Q4DHW4_TRYCC	DUF3437 domain-containing protein. (2208 aa)
	Q4DGS4_TRYCC	Ubiquitin-like protein, putative. (622 aa)
	Q4DGE6_TRYCC	Protein kinase, putative. (1369 aa)
	Q4CMB8_TRYCC	Proteasome alpha 7 subunit, putative. (49 aa)
	Q4DBH0_TRYCC	Proteasome endopeptidase complex. (190 aa)
	Q4D8U7_TRYCC	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (311 aa)
	Q4CYK5_TRYCC	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (247 aa)
	Q4D1T6_TRYCC	Ubiquitin/ribosomal protein S27a, putative. (150 aa)
	Q4D240_TRYCC	DUF3437 domain-containing protein. (277 aa)
	Q4D5X3_TRYCC	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (265 aa)
	Q4D6K0_TRYCC	Ubiquitin-like protein, putative. (624 aa)
	Q4CYD3_TRYCC	Protein kinase, putative; Belongs to the protein kinase superfamily. (472 aa)

Your Current Organism:

Trypanosoma cruzi

NCBI taxonomy Id: 353153
Other names: T. cruzi strain CL Brener, Trypanosoma cruzi strain CL Brener

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Q4CMB8_TRYCC	Q4CX04_TRYCC	Q4CMB8	Q4CX04	Proteasome alpha 7 subunit, putative.	Ubiquitin/ribosomal protein S27a, putative.	0.723
Q4CMB8_TRYCC	Q4CXN0_TRYCC	Q4CMB8	Q4CXN0	Proteasome alpha 7 subunit, putative.	Ubiquitin/ribosomal protein S27a, putative.	0.723
Q4CMB8_TRYCC	Q4CYK5_TRYCC	Q4CMB8	Q4CYK5	Proteasome alpha 7 subunit, putative.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.999
Q4CMB8_TRYCC	Q4D1T6_TRYCC	Q4CMB8	Q4D1T6	Proteasome alpha 7 subunit, putative.	Ubiquitin/ribosomal protein S27a, putative.	0.723
Q4CMB8_TRYCC	Q4D240_TRYCC	Q4CMB8	Q4D240	Proteasome alpha 7 subunit, putative.	DUF3437 domain-containing protein.	0.849
Q4CMB8_TRYCC	Q4D6K0_TRYCC	Q4CMB8	Q4D6K0	Proteasome alpha 7 subunit, putative.	Ubiquitin-like protein, putative.	0.723
Q4CMB8_TRYCC	Q4D6T6_TRYCC	Q4CMB8	Q4D6T6	Proteasome alpha 7 subunit, putative.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.986
Q4CMB8_TRYCC	Q4D8U7_TRYCC	Q4CMB8	Q4D8U7	Proteasome alpha 7 subunit, putative.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.986
Q4CMB8_TRYCC	Q4DBH0_TRYCC	Q4CMB8	Q4DBH0	Proteasome alpha 7 subunit, putative.	Proteasome endopeptidase complex.	0.751
Q4CMB8_TRYCC	Q4DGS4_TRYCC	Q4CMB8	Q4DGS4	Proteasome alpha 7 subunit, putative.	Ubiquitin-like protein, putative.	0.723
Q4CMB8_TRYCC	Q4DHW4_TRYCC	Q4CMB8	Q4DHW4	Proteasome alpha 7 subunit, putative.	DUF3437 domain-containing protein.	0.849
Q4CMB8_TRYCC	Q4DPH9_TRYCC	Q4CMB8	Q4DPH9	Proteasome alpha 7 subunit, putative.	Uncharacterized protein.	0.849
Q4CMB8_TRYCC	Q4DSQ4_TRYCC	Q4CMB8	Q4DSQ4	Proteasome alpha 7 subunit, putative.	Ubiquitin/ribosomal protein S27a, putative.	0.723
Q4CMB8_TRYCC	Q4DW25_TRYCC	Q4CMB8	Q4DW25	Proteasome alpha 7 subunit, putative.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.992
Q4CMB8_TRYCC	Q4DXC0_TRYCC	Q4CMB8	Q4DXC0	Proteasome alpha 7 subunit, putative.	Proteasome regulatory non-ATPase subunit 2, putative; Belongs to the proteasome subunit S1 family.	0.997
Q4CMB8_TRYCC	Q4E0L9_TRYCC	Q4CMB8	Q4E0L9	Proteasome alpha 7 subunit, putative.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.992
Q4CMB8_TRYCC	Q4E4R6_TRYCC	Q4CMB8	Q4E4R6	Proteasome alpha 7 subunit, putative.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.999
Q4CT97_TRYCC	Q4CUA3_TRYCC	Q4CT97	Q4CUA3	Protein kinase, putative.	Protein kinase, putative; Belongs to the protein kinase superfamily.	0.646
Q4CT97_TRYCC	Q4CYD3_TRYCC	Q4CT97	Q4CYD3	Protein kinase, putative.	Protein kinase, putative; Belongs to the protein kinase superfamily.	0.646
Q4CT97_TRYCC	Q4DGE6_TRYCC	Q4CT97	Q4DGE6	Protein kinase, putative.	Protein kinase, putative.	0.646