(36 nodes) RNA Polymerase I Transcription network (Trypanosoma cruzi)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Q4DY18_TRYCC	DNA-directed RNA polymerase II, putative. (282 aa)
	Q4E4P5_TRYCC	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1591 aa)
	Q4E5J2_TRYCC	DNA-directed RNA polymerases II, putative. (219 aa)
	Q4E5J3_TRYCC	DNA-directed RNA polymerase II, putative. (282 aa)
	Q4CTD7_TRYCC	Histone H2B; Belongs to the histone H2B family. (112 aa)
	Q4CTD8_TRYCC	Histone H2B; Belongs to the histone H2B family. (112 aa)
	Q4CTY7_TRYCC	DNA-directed RNA polymerase subunit, putative. (84 aa)
	Q4CZ36_TRYCC	TFIIH basal transcription factor complex helicase subunit, putative. (804 aa)
	Q4D0I3_TRYCC	TFIID-like protein, putative. (245 aa)
	Q4D0Y6_TRYCC	DNA-directed RNA polymerase subunit, putative. (144 aa)
	Q4D133_TRYCC	DNA-directed RNA polymerase I largest subunit, putative. (1802 aa)
	Q4D483_TRYCC	DNA-directed RNA polymerase I largest subunit, putative. (159 aa)
	Q4D5K3_TRYCC	DNA repair helicase, putative. (778 aa)
	Q4D5K7_TRYCC	DNA-directed RNA polymerase I largest subunit, putative. (784 aa)
	Q4D7L7_TRYCC	DNA-directed RNA polymerase subunit, putative. (84 aa)
	Q4D8C5_TRYCC	DNA repair helicase and transcription factor protein, putative. (925 aa)
	Q4D8D9_TRYCC	Nitroreductase, putative. (312 aa)
	Q4DCA7_TRYCC	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (149 aa)
	Q4DCW9_TRYCC	Nitroreductase, putative. (313 aa)
	Q4DDD8_TRYCC	DNA-directed RNA polymerase subunit, putative. (144 aa)
	Q4DDL2_TRYCC	DNA-directed RNA polymerase, alpha subunit, putative. (393 aa)
	Q4DF86_TRYCC	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (501 aa)
	Q4DHB9_TRYCC	Histone H2B; Belongs to the histone H2B family. (143 aa)
	Q4DHR0_TRYCC	DNA repair helicase and transcription factor protein, putative. (925 aa)
	Q4DHY8_TRYCC	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (501 aa)
	Q4DK05_TRYCC	TFIID-like protein, putative. (263 aa)
	Q4DLU2_TRYCC	DNA-directed RNA polymerase ii 8.2 Kd polypeptide, putative. (77 aa)
	Q4DMD5_TRYCC	Histone H2B; Belongs to the histone H2B family. (143 aa)
	Q4DR34_TRYCC	Uncharacterized protein. (130 aa)
	Q4DRD4_TRYCC	DNA-directed RNA polymerase, alpha subunit, putative. (393 aa)
	Q4DY61_TRYCC	DNA repair and transcription factor protein, putative. (356 aa)
	Q4CK99_TRYCC	DNA-directed RNA polymerase I largest subunit, putative. (338 aa)
	Q4CKJ3_TRYCC	DNA-directed RNA polymerase I largest subunit, putative. (433 aa)
	Q4CKK7_TRYCC	DNA-directed RNA polymerase I largest subunit, putative. (437 aa)
	Q4CMV3_TRYCC	TFIIH basal transcription factor complex helicase subunit, putative. (452 aa)
	Q4CMX3_TRYCC	DNA-directed RNA polymerase subunit, putative. (77 aa)

Your Current Organism:

Trypanosoma cruzi

NCBI taxonomy Id: 353153
Other names: T. cruzi strain CL Brener, Trypanosoma cruzi strain CL Brener

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Q4CK99_TRYCC	Q4CKJ3_TRYCC	Q4CK99	Q4CKJ3	DNA-directed RNA polymerase I largest subunit, putative.	DNA-directed RNA polymerase I largest subunit, putative.	0.919
Q4CK99_TRYCC	Q4CMV3_TRYCC	Q4CK99	Q4CMV3	DNA-directed RNA polymerase I largest subunit, putative.	TFIIH basal transcription factor complex helicase subunit, putative.	0.560
Q4CK99_TRYCC	Q4CMX3_TRYCC	Q4CK99	Q4CMX3	DNA-directed RNA polymerase I largest subunit, putative.	DNA-directed RNA polymerase subunit, putative.	0.781
Q4CK99_TRYCC	Q4CTY7_TRYCC	Q4CK99	Q4CTY7	DNA-directed RNA polymerase I largest subunit, putative.	DNA-directed RNA polymerase subunit, putative.	0.781
Q4CK99_TRYCC	Q4CZ36_TRYCC	Q4CK99	Q4CZ36	DNA-directed RNA polymerase I largest subunit, putative.	TFIIH basal transcription factor complex helicase subunit, putative.	0.560
Q4CK99_TRYCC	Q4D0I3_TRYCC	Q4CK99	Q4D0I3	DNA-directed RNA polymerase I largest subunit, putative.	TFIID-like protein, putative.	0.725
Q4CK99_TRYCC	Q4D0Y6_TRYCC	Q4CK99	Q4D0Y6	DNA-directed RNA polymerase I largest subunit, putative.	DNA-directed RNA polymerase subunit, putative.	0.868
Q4CK99_TRYCC	Q4D5K3_TRYCC	Q4CK99	Q4D5K3	DNA-directed RNA polymerase I largest subunit, putative.	DNA repair helicase, putative.	0.555
Q4CK99_TRYCC	Q4D7L7_TRYCC	Q4CK99	Q4D7L7	DNA-directed RNA polymerase I largest subunit, putative.	DNA-directed RNA polymerase subunit, putative.	0.781
Q4CK99_TRYCC	Q4D8C5_TRYCC	Q4CK99	Q4D8C5	DNA-directed RNA polymerase I largest subunit, putative.	DNA repair helicase and transcription factor protein, putative.	0.555
Q4CK99_TRYCC	Q4D8D9_TRYCC	Q4CK99	Q4D8D9	DNA-directed RNA polymerase I largest subunit, putative.	Nitroreductase, putative.	0.917
Q4CK99_TRYCC	Q4DCA7_TRYCC	Q4CK99	Q4DCA7	DNA-directed RNA polymerase I largest subunit, putative.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.967
Q4CK99_TRYCC	Q4DCW9_TRYCC	Q4CK99	Q4DCW9	DNA-directed RNA polymerase I largest subunit, putative.	Nitroreductase, putative.	0.917
Q4CK99_TRYCC	Q4DDD8_TRYCC	Q4CK99	Q4DDD8	DNA-directed RNA polymerase I largest subunit, putative.	DNA-directed RNA polymerase subunit, putative.	0.868
Q4CK99_TRYCC	Q4DDL2_TRYCC	Q4CK99	Q4DDL2	DNA-directed RNA polymerase I largest subunit, putative.	DNA-directed RNA polymerase, alpha subunit, putative.	0.957
Q4CK99_TRYCC	Q4DHR0_TRYCC	Q4CK99	Q4DHR0	DNA-directed RNA polymerase I largest subunit, putative.	DNA repair helicase and transcription factor protein, putative.	0.555
Q4CK99_TRYCC	Q4DK05_TRYCC	Q4CK99	Q4DK05	DNA-directed RNA polymerase I largest subunit, putative.	TFIID-like protein, putative.	0.725
Q4CK99_TRYCC	Q4DLU2_TRYCC	Q4CK99	Q4DLU2	DNA-directed RNA polymerase I largest subunit, putative.	DNA-directed RNA polymerase ii 8.2 Kd polypeptide, putative.	0.781
Q4CK99_TRYCC	Q4DR34_TRYCC	Q4CK99	Q4DR34	DNA-directed RNA polymerase I largest subunit, putative.	Uncharacterized protein.	0.868
Q4CK99_TRYCC	Q4DRD4_TRYCC	Q4CK99	Q4DRD4	DNA-directed RNA polymerase I largest subunit, putative.	DNA-directed RNA polymerase, alpha subunit, putative.	0.957