(57 nodes) DNA Damage Bypass network (Trypanosoma cruzi)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Q4D5H5_TRYCC	Cell division cycle protein, putative. (737 aa)
	Q4DWB5_TRYCC	Transitional endoplasmic reticulum ATPase, putative. (778 aa)
	Q4DW61_TRYCC	ATPase, putative. (628 aa)
	Q4DV56_TRYCC	Replication factor C, subunit 1, putative. (582 aa)
	Q4DUG6_TRYCC	Replication factor C, subunit 3, putative. (355 aa)
	Q4DTI5_TRYCC	Uncharacterized protein. (624 aa)
	Q4DTC9_TRYCC	CBFD_NFYB_HMF domain-containing protein. (141 aa)
	Q4DT90_TRYCC	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2237 aa)
	Q4DSQ4_TRYCC	Ubiquitin/ribosomal protein S27a, putative. (150 aa)
	Q4DS46_TRYCC	ATPase_AAA_core domain-containing protein. (1185 aa)
	Q4DRV9_TRYCC	ATPase domain protein, putative; Belongs to the AAA ATPase family. (572 aa)
	Q4DNR1_TRYCC	Replication factor C, subunit 4, putative. (340 aa)
	Q4CQ46_TRYCC	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (289 aa)
	Q4CRP5_TRYCC	CULLIN_2 domain-containing protein; Belongs to the cullin family. (1017 aa)
	Q4CSB8_TRYCC	Ubiquitin fusion degradation protein, putative. (187 aa)
	Q4CTM0_TRYCC	CULLIN_2 domain-containing protein; Belongs to the cullin family. (909 aa)
	Q4CTT9_TRYCC	Ubiquitin hydrolase, putative; Belongs to the peptidase C19 family. (438 aa)
	Q4DWK0_TRYCC	AAA ATPase, putative. (1214 aa)
	Q4DWU7_TRYCC	Damage-specific DNA binding protein, putative. (774 aa)
	Q4DX64_TRYCC	Damage-specific DNA binding protein, putative. (766 aa)
	Q4DXC9_TRYCC	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (465 aa)
	Q4E0Y1_TRYCC	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (289 aa)
	Q4E128_TRYCC	Replication factor C, subunit 5, putative. (349 aa)
	Q4E4K9_TRYCC	ATPase, putative. (667 aa)
	Q4E554_TRYCC	AAA ATPase, putative. (1214 aa)
	Q4DJB3_TRYCC	Replication factor C, subunit 4, putative. (182 aa)
	Q4DJY8_TRYCC	DNA polymerase epsilon subunit B, putative. (534 aa)
	Q4DKU0_TRYCC	DNA polymerase. (1885 aa)
	Q4DMU3_TRYCC	Replication factor C, subunit 2, putative. (347 aa)
	Q4DH19_TRYCC	ATPase, putative. (628 aa)
	Q4DGS4_TRYCC	Ubiquitin-like protein, putative. (622 aa)
	Q4DGF2_TRYCC	Cullin-like protein, putative; Belongs to the cullin family. (708 aa)
	Q4DBR5_TRYCC	DNA damage repair protein, putative. (615 aa)
	Q4DB05_TRYCC	CULLIN_2 domain-containing protein; Belongs to the cullin family. (696 aa)
	Q4D8X7_TRYCC	Damage-specific DNA binding protein, putative. (377 aa)
	Q4D6K0_TRYCC	Ubiquitin-like protein, putative. (624 aa)
	Q4DNK8_TRYCC	Ubiquitin hydrolase, putative; Belongs to the peptidase C19 family. (438 aa)
	Q4D5I0_TRYCC	DNA polymerase kappa, putative. (604 aa)
	Q4D5H8_TRYCC	DNA polymerase kappa, putative. (514 aa)
	Q4D4L1_TRYCC	Cell division cycle protein, putative. (658 aa)
	Q4D459_TRYCC	Replication factor C, subunit 4, putative. (144 aa)
	Q4D440_TRYCC	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2195 aa)
	Q4D3T9_TRYCC	DNA damage repair protein, putative. (615 aa)
	Q4D3L1_TRYCC	CBFD_NFYB_HMF domain-containing protein. (199 aa)
	Q4D2V5_TRYCC	Replication factor C, subunit 3, putative. (355 aa)
	Q4D2L7_TRYCC	ATPase_AAA_core domain-containing protein. (1187 aa)
	Q4D1T6_TRYCC	Ubiquitin/ribosomal protein S27a, putative. (150 aa)
	Q4D1M9_TRYCC	DNA polymerase epsilon subunit B, putative. (534 aa)
	Q4D0M2_TRYCC	DNA polymerase kappa, putative. (597 aa)
	Q4D0M0_TRYCC	DNA polymerase kappa, putative. (514 aa)
	Q4CYY6_TRYCC	ATPase domain protein, putative; Belongs to the AAA ATPase family. (534 aa)
	Q4CXN0_TRYCC	Ubiquitin/ribosomal protein S27a, putative. (211 aa)
	Q4CX33_TRYCC	CULLIN_2 domain-containing protein; Belongs to the cullin family. (910 aa)
	Q4CX04_TRYCC	Ubiquitin/ribosomal protein S27a, putative. (209 aa)
	Q4CWN3_TRYCC	Replication factor C, subunit 2, putative. (347 aa)
	Q4CVQ3_TRYCC	Damage-specific DNA binding protein, putative. (508 aa)
	Q4CVL6_TRYCC	AAA ATPase, putative. (783 aa)

Your Current Organism:

Trypanosoma cruzi

NCBI taxonomy Id: 353153
Other names: T. cruzi strain CL Brener, Trypanosoma cruzi strain CL Brener

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Q4CQ46_TRYCC	Q4CRP5_TRYCC	Q4CQ46	Q4CRP5	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.610
Q4CQ46_TRYCC	Q4CSB8_TRYCC	Q4CQ46	Q4CSB8	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Ubiquitin fusion degradation protein, putative.	0.789
Q4CQ46_TRYCC	Q4CTM0_TRYCC	Q4CQ46	Q4CTM0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.610
Q4CQ46_TRYCC	Q4CTT9_TRYCC	Q4CQ46	Q4CTT9	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Ubiquitin hydrolase, putative; Belongs to the peptidase C19 family.	0.670
Q4CQ46_TRYCC	Q4CVL6_TRYCC	Q4CQ46	Q4CVL6	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	AAA ATPase, putative.	0.490
Q4CQ46_TRYCC	Q4CVQ3_TRYCC	Q4CQ46	Q4CVQ3	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Damage-specific DNA binding protein, putative.	0.611
Q4CQ46_TRYCC	Q4CWN3_TRYCC	Q4CQ46	Q4CWN3	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Replication factor C, subunit 2, putative.	0.996
Q4CQ46_TRYCC	Q4CX04_TRYCC	Q4CQ46	Q4CX04	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Ubiquitin/ribosomal protein S27a, putative.	0.802
Q4CQ46_TRYCC	Q4CX33_TRYCC	Q4CQ46	Q4CX33	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.610
Q4CQ46_TRYCC	Q4CXN0_TRYCC	Q4CQ46	Q4CXN0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Ubiquitin/ribosomal protein S27a, putative.	0.802
Q4CQ46_TRYCC	Q4CYY6_TRYCC	Q4CQ46	Q4CYY6	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	ATPase domain protein, putative; Belongs to the AAA ATPase family.	0.490
Q4CQ46_TRYCC	Q4D0M0_TRYCC	Q4CQ46	Q4D0M0	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA polymerase kappa, putative.	0.924
Q4CQ46_TRYCC	Q4D0M2_TRYCC	Q4CQ46	Q4D0M2	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA polymerase kappa, putative.	0.924
Q4CQ46_TRYCC	Q4D1M9_TRYCC	Q4CQ46	Q4D1M9	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA polymerase epsilon subunit B, putative.	0.820
Q4CQ46_TRYCC	Q4D1T6_TRYCC	Q4CQ46	Q4D1T6	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Ubiquitin/ribosomal protein S27a, putative.	0.802
Q4CQ46_TRYCC	Q4D2L7_TRYCC	Q4CQ46	Q4D2L7	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	ATPase_AAA_core domain-containing protein.	0.966
Q4CQ46_TRYCC	Q4D2V5_TRYCC	Q4CQ46	Q4D2V5	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	Replication factor C, subunit 3, putative.	0.989
Q4CQ46_TRYCC	Q4D3L1_TRYCC	Q4CQ46	Q4D3L1	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	CBFD_NFYB_HMF domain-containing protein.	0.755
Q4CQ46_TRYCC	Q4D3T9_TRYCC	Q4CQ46	Q4D3T9	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA damage repair protein, putative.	0.976
Q4CQ46_TRYCC	Q4D440_TRYCC	Q4CQ46	Q4D440	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.976