(15 nodes) (2010) N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. network (Trypanosoma cruzi)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	Q4CMB9_TRYCC	Clathrin heavy chain, putative. (413 aa)
	Q4CLA1_TRYCC	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
	Q4CKX3_TRYCC	Clathrin heavy chain, putative. (516 aa)
	ATAT1_TRYCC	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (329 aa)
	Q4CS04_TRYCC	Flagellar calcium-binding protein, putative. (108 aa)
	Q4CTW9_TRYCC	Flagellar calcium-binding protein, putative. (79 aa)
	Q4CS05_TRYCC	Flagellar calcium-binding protein, putative. (211 aa)
	Q4CTX0_TRYCC	Flagellar calcium-binding protein, putative. (211 aa)
	Q4CTX1_TRYCC	Flagellar calcium-binding protein, putative. (211 aa)
	Q4CTX2_TRYCC	Flagellar calcium-binding protein, putative. (211 aa)
	Q4D5X2_TRYCC	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1704 aa)
	Q4DK26_TRYCC	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (452 aa)
	Q4DRI4_TRYCC	Flagellar calcium-binding protein, putative. (181 aa)
	Q4DRI5_TRYCC	Flagellar calcium-binding protein, putative. (211 aa)
	Q4E2V2_TRYCC	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (451 aa)

Your Current Organism:

Trypanosoma cruzi

NCBI taxonomy Id: 353153
Other names: T. cruzi strain CL Brener, Trypanosoma cruzi strain CL Brener

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAT1_TRYCC	Q4CLA1_TRYCC	Q4CQJ5	Q4CLA1	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...]	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.544
Q4CKX3_TRYCC	Q4CLA1_TRYCC	Q4CKX3	Q4CLA1	Clathrin heavy chain, putative.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.662
Q4CKX3_TRYCC	Q4CMB9_TRYCC	Q4CKX3	Q4CMB9	Clathrin heavy chain, putative.	Clathrin heavy chain, putative.	0.993
Q4CKX3_TRYCC	Q4D5X2_TRYCC	Q4CKX3	Q4D5X2	Clathrin heavy chain, putative.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.900
Q4CLA1_TRYCC	ATAT1_TRYCC	Q4CLA1	Q4CQJ5	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...]	0.544
Q4CLA1_TRYCC	Q4CKX3_TRYCC	Q4CLA1	Q4CKX3	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Clathrin heavy chain, putative.	0.662
Q4CLA1_TRYCC	Q4CMB9_TRYCC	Q4CLA1	Q4CMB9	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Clathrin heavy chain, putative.	0.662
Q4CLA1_TRYCC	Q4D5X2_TRYCC	Q4CLA1	Q4D5X2	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.662
Q4CMB9_TRYCC	Q4CKX3_TRYCC	Q4CMB9	Q4CKX3	Clathrin heavy chain, putative.	Clathrin heavy chain, putative.	0.993
Q4CMB9_TRYCC	Q4CLA1_TRYCC	Q4CMB9	Q4CLA1	Clathrin heavy chain, putative.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.662
Q4CMB9_TRYCC	Q4D5X2_TRYCC	Q4CMB9	Q4D5X2	Clathrin heavy chain, putative.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.900
Q4CS04_TRYCC	Q4DK26_TRYCC	Q4CS04	Q4DK26	Flagellar calcium-binding protein, putative.	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family.	0.601
Q4CS04_TRYCC	Q4E2V2_TRYCC	Q4CS04	Q4E2V2	Flagellar calcium-binding protein, putative.	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family.	0.601
Q4CS05_TRYCC	Q4DK26_TRYCC	Q4CS05	Q4DK26	Flagellar calcium-binding protein, putative.	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family.	0.601
Q4CS05_TRYCC	Q4E2V2_TRYCC	Q4CS05	Q4E2V2	Flagellar calcium-binding protein, putative.	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family.	0.601
Q4CTW9_TRYCC	Q4DK26_TRYCC	Q4CTW9	Q4DK26	Flagellar calcium-binding protein, putative.	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family.	0.601
Q4CTW9_TRYCC	Q4E2V2_TRYCC	Q4CTW9	Q4E2V2	Flagellar calcium-binding protein, putative.	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family.	0.601
Q4CTX0_TRYCC	Q4DK26_TRYCC	Q4CTX0	Q4DK26	Flagellar calcium-binding protein, putative.	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family.	0.601
Q4CTX0_TRYCC	Q4E2V2_TRYCC	Q4CTX0	Q4E2V2	Flagellar calcium-binding protein, putative.	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family.	0.601
Q4CTX1_TRYCC	Q4DK26_TRYCC	Q4CTX1	Q4DK26	Flagellar calcium-binding protein, putative.	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family.	0.601