(31 nodes) (2018) Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. network (Trypanosoma cruzi)

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	PURA1_TRYCC	Adenylosuccinate synthetase 1; Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). (616 aa)
	Q4CLL4_TRYCC	AMP deaminase, putative. (249 aa)
	Q4CMY1_TRYCC	Nucleoside hydrolase, putative. (70 aa)
	Q4DMR1_TRYCC	AMP deaminase, putative. (647 aa)
	Q4DQ27_TRYCC	Phosphotransferase. (471 aa)
	Q4DQ97_TRYCC	Purine nucleoside phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (307 aa)
	Q4DUS4_TRYCC	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (452 aa)
	Q4DUW5_TRYCC	Nucleoside hydrolase, putative. (357 aa)
	Q4DWY4_TRYCC	AMP deaminase, putative. (978 aa)
	Q4DZW1_TRYCC	Purine nucleoside phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (307 aa)
	Q4E0S4_TRYCC	Adenosine kinase, putative. (346 aa)
	Q4CNX6_TRYCC	GMP synthase, putative. (221 aa)
	Q4E1D4_TRYCC	GMP synthase, putative. (657 aa)
	Q4CUG6_TRYCC	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (512 aa)
	Q4CVB3_TRYCC	AMP deaminase, putative. (193 aa)
	Q4CVK9_TRYCC	Adenosine kinase, putative. (346 aa)
	PURA2_TRYCC	Adenylosuccinate synthetase 2; Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). (616 aa)
	Q4CXJ7_TRYCC	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (462 aa)
	Q4CY14_TRYCC	Adenosine kinase, putative. (359 aa)
	Q4CYT2_TRYCC	Adenosine kinase, putative. (359 aa)
	Q4DII0_TRYCC	AMP deaminase, putative. (1522 aa)
	Q4DLR1_TRYCC	AMP deaminase, putative. (240 aa)
	GMPR-2	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (491 aa)
	Q4E4G2_TRYCC	AMP deaminase, putative. (1429 aa)
	Q4DM82_TRYCC	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (512 aa)
	Q4D3P5_TRYCC	Phosphotransferase. (471 aa)
	Q4D5V1_TRYCC	AMP deaminase, putative. (791 aa)
	Q4D711_TRYCC	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (452 aa)
	Q4DAJ9_TRYCC	AMP deaminase, putative. (901 aa)
	Q4DBH5_TRYCC	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (462 aa)
	GMPR	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (491 aa)

Your Current Organism:

Trypanosoma cruzi

NCBI taxonomy Id: 353153
Other names: T. cruzi strain CL Brener, Trypanosoma cruzi strain CL Brener

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GMPR	PURA1_TRYCC	Q4DFE7	Q4DLT6	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Adenylosuccinate synthetase 1; Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).	0.991
GMPR	PURA2_TRYCC	Q4DFE7	Q4CWX1	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Adenylosuccinate synthetase 2; Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity).	0.991
GMPR	Q4CLL4_TRYCC	Q4DFE7	Q4CLL4	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	AMP deaminase, putative.	0.965
GMPR	Q4CMY1_TRYCC	Q4DFE7	Q4CMY1	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Nucleoside hydrolase, putative.	0.415
GMPR	Q4CNX6_TRYCC	Q4DFE7	Q4CNX6	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	GMP synthase, putative.	0.965
GMPR	Q4CVB3_TRYCC	Q4DFE7	Q4CVB3	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	AMP deaminase, putative.	0.670
GMPR	Q4CVK9_TRYCC	Q4DFE7	Q4CVK9	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Adenosine kinase, putative.	0.644
GMPR	Q4CXJ7_TRYCC	Q4DFE7	Q4CXJ7	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.861
GMPR	Q4CY14_TRYCC	Q4DFE7	Q4CY14	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Adenosine kinase, putative.	0.660
GMPR	Q4CYT2_TRYCC	Q4DFE7	Q4CYT2	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Adenosine kinase, putative.	0.644
GMPR	Q4D5V1_TRYCC	Q4DFE7	Q4D5V1	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	AMP deaminase, putative.	0.670
GMPR	Q4D711_TRYCC	Q4DFE7	Q4D711	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	0.698
GMPR	Q4DAJ9_TRYCC	Q4DFE7	Q4DAJ9	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	AMP deaminase, putative.	0.965
GMPR	Q4DBH5_TRYCC	Q4DFE7	Q4DBH5	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.861
GMPR	Q4DII0_TRYCC	Q4DFE7	Q4DII0	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	AMP deaminase, putative.	0.670
GMPR	Q4DLR1_TRYCC	Q4DFE7	Q4DLR1	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	AMP deaminase, putative.	0.670
GMPR	Q4DMR1_TRYCC	Q4DFE7	Q4DMR1	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	AMP deaminase, putative.	0.670
GMPR	Q4DQ97_TRYCC	Q4DFE7	Q4DQ97	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Purine nucleoside phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.	0.799
GMPR	Q4DUS4_TRYCC	Q4DFE7	Q4DUS4	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	0.698
GMPR	Q4DUW5_TRYCC	Q4DFE7	Q4DUW5	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	Nucleoside hydrolase, putative.	0.415