61 items (Trypanosoma cruzi) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Q4CW17_TRYCC	Transketolase, putative. (534 aa)
	Q4DGP8_TRYCC	Phosphoglycerate kinase. (527 aa)
	Q4DG86_TRYCC	25 kDa translation elongation factor 1-beta, putative; Belongs to the EF-1-beta/EF-1-delta family. (222 aa)
	Q4DG65_TRYCC	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (433 aa)
	Q4DCN9_TRYCC	Glyceraldehyde-3-phosphate dehydrogenase. (359 aa)
	Q4DBS3_TRYCC	Elongation factor 2, putative. (154 aa)
	Q4D9Z4_TRYCC	Pyruvate kinase; Belongs to the pyruvate kinase family. (499 aa)
	Q4D9M5_TRYCC	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative. (239 aa)
	Q4D6Y4_TRYCC	Heat shock protein 70, putative. (70 aa)
	Q4D5X0_TRYCC	Elongation factor 2, putative. (846 aa)
	Q4D3Y9_TRYCC	Glyceraldehyde 3-phosphate dehydrogenase, putative. (137 aa)
	Q4D3T1_TRYCC	Elongation factor 2, putative. (846 aa)
	Q4D193_TRYCC	Phosphoglycerate kinase. (419 aa)
	Q4D192_TRYCC	Phosphoglycerate kinase. (588 aa)
	Q4D118_TRYCC	Heat shock protein 70, putative. (249 aa)
	Q4D0X5_TRYCC	6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (477 aa)
	Q4D030_TRYCC	Lectin, putative. (550 aa)
	Q4CW94_TRYCC	Glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative. (214 aa)
	Q4CVJ5_TRYCC	Citrate synthase; Belongs to the citrate synthase family. (472 aa)
	Q4CVB7_TRYCC	Glyceraldehyde-3-phosphate dehydrogenase, putative; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (371 aa)
	Q4CUD7_TRYCC	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (331 aa)
	Q4CUA0_TRYCC	Heat shock protein 70, putative. (291 aa)
	Q4CQA2_TRYCC	25 kDa translation elongation factor 1-beta; Belongs to the EF-1-beta/EF-1-delta family. (222 aa)
	Q4CNX4_TRYCC	Elongation factor 2, putative. (173 aa)
	Q4CN65_TRYCC	Phosphoglycerate kinase, putative. (201 aa)
	Q4CMZ5_TRYCC	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (331 aa)
	Q4CLV1_TRYCC	Transketolase, putative. (120 aa)
	Q4CLF1_TRYCC	Glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative. (246 aa)
	Q4CK86_TRYCC	Heat shock protein 70 (HSP70), putative. (140 aa)
	Q4DGU6_TRYCC	Translation elongation factor EF-2, putative. (890 aa)
	Q4DHF0_TRYCC	Glyceraldehyde-3-phosphate dehydrogenase. (359 aa)
	Q4DHU0_TRYCC	Lectin, putative. (562 aa)
	Q4DMG2_TRYCC	Glyceraldehyde-3-phosphate dehydrogenase. (338 aa)
	Q4DMN8_TRYCC	Elongation factor 2, putative. (38 aa)
	Q4DNV7_TRYCC	Phosphoglycerate kinase. (503 aa)
	Q4DNV8_TRYCC	Phosphoglycerate kinase. (419 aa)
	Q4DP98_TRYCC	Phosphoglycerate kinase, putative. (115 aa)
	Q4DQY7_TRYCC	Acetyl-coenzyme A synthetase. (677 aa)
	Q4DTM3_TRYCC	Heat shock protein 70, putative; Belongs to the heat shock protein 70 family. (680 aa)
	Q4DTM8_TRYCC	Heat shock protein 70 (HSP70), putative; Belongs to the heat shock protein 70 family. (677 aa)
	Q4DTM9_TRYCC	Heat shock protein 70 (HSP70), putative; Belongs to the heat shock protein 70 family. (654 aa)
	Q4DU82_TRYCC	Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (672 aa)
	Q4DU92_TRYCC	6-phosphogluconate dehydrogenase, decarboxylating. (145 aa)
	Q4DV21_TRYCC	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative. (223 aa)
	Q4DV43_TRYCC	Triosephosphate isomerase. (251 aa)
	Q4DWC3_TRYCC	Translation elongation factor 1-beta, putative; Belongs to the EF-1-beta/EF-1-delta family. (197 aa)
	Q4DX96_TRYCC	Phosphoglycerate kinase. (527 aa)
	Q4DYN2_TRYCC	Acetyl-coenzyme A synthetase. (677 aa)
	RPL18	60S ribosomal protein L18. (193 aa)
	Q4DZT1_TRYCC	Glyceraldehyde-3-phosphate dehydrogenase. (338 aa)
	Q4E0F6_TRYCC	Eukaryotic initiation factor 4a, putative; Belongs to the DEAD box helicase family. (438 aa)
	Q4E0G9_TRYCC	Heat shock protein 70 (HSP70), putative. (883 aa)
	IF4A_TRYCC	Probable eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). (404 aa)
	Q4E175_TRYCC	Heat shock protein 70 (HSP70), putative. (883 aa)
	Q4E1U3_TRYCC	Pyruvate kinase; Belongs to the pyruvate kinase family. (499 aa)
	Q4E2S6_TRYCC	Phosphoglycerate kinase. (906 aa)
	Q4E4E5_TRYCC	Glyceraldehyde-3-phosphate dehydrogenase. (338 aa)
	Q4E4F8_TRYCC	Glyceraldehyde-3-phosphate dehydrogenase, putative; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (347 aa)
	Q4E4L7_TRYCC	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (413 aa)
	Q4E5G5_TRYCC	Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (898 aa)
	Q4E5I4_TRYCC	Citrate synthase; Belongs to the citrate synthase family. (472 aa)

Your Current Organism:

Trypanosoma cruzi

NCBI taxonomy Id: 353153
Other names: T. cruzi strain CL Brener, Trypanosoma cruzi strain CL Brener

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IF4A_TRYCC	Q4CNX4_TRYCC	Q4E162	Q4CNX4	Probable eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).	Elongation factor 2, putative.	0.458
IF4A_TRYCC	Q4D3T1_TRYCC	Q4E162	Q4D3T1	Probable eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).	Elongation factor 2, putative.	0.458
IF4A_TRYCC	Q4D5X0_TRYCC	Q4E162	Q4D5X0	Probable eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).	Elongation factor 2, putative.	0.458
IF4A_TRYCC	Q4DBS3_TRYCC	Q4E162	Q4DBS3	Probable eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).	Elongation factor 2, putative.	0.458
IF4A_TRYCC	Q4DGU6_TRYCC	Q4E162	Q4DGU6	Probable eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).	Translation elongation factor EF-2, putative.	0.434
IF4A_TRYCC	Q4DMN8_TRYCC	Q4E162	Q4DMN8	Probable eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).	Elongation factor 2, putative.	0.458
IF4A_TRYCC	Q4E0F6_TRYCC	Q4E162	Q4E0F6	Probable eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).	Eukaryotic initiation factor 4a, putative; Belongs to the DEAD box helicase family.	0.900
Q4CK86_TRYCC	Q4CNX4_TRYCC	Q4CK86	Q4CNX4	Heat shock protein 70 (HSP70), putative.	Elongation factor 2, putative.	0.486
Q4CK86_TRYCC	Q4CUA0_TRYCC	Q4CK86	Q4CUA0	Heat shock protein 70 (HSP70), putative.	Heat shock protein 70, putative.	0.926
Q4CK86_TRYCC	Q4D3T1_TRYCC	Q4CK86	Q4D3T1	Heat shock protein 70 (HSP70), putative.	Elongation factor 2, putative.	0.486
Q4CK86_TRYCC	Q4D5X0_TRYCC	Q4CK86	Q4D5X0	Heat shock protein 70 (HSP70), putative.	Elongation factor 2, putative.	0.486
Q4CK86_TRYCC	Q4D6Y4_TRYCC	Q4CK86	Q4D6Y4	Heat shock protein 70 (HSP70), putative.	Heat shock protein 70, putative.	0.602
Q4CK86_TRYCC	Q4DBS3_TRYCC	Q4CK86	Q4DBS3	Heat shock protein 70 (HSP70), putative.	Elongation factor 2, putative.	0.486
Q4CK86_TRYCC	Q4DGU6_TRYCC	Q4CK86	Q4DGU6	Heat shock protein 70 (HSP70), putative.	Translation elongation factor EF-2, putative.	0.427
Q4CK86_TRYCC	Q4DMN8_TRYCC	Q4CK86	Q4DMN8	Heat shock protein 70 (HSP70), putative.	Elongation factor 2, putative.	0.486
Q4CK86_TRYCC	Q4E0G9_TRYCC	Q4CK86	Q4E0G9	Heat shock protein 70 (HSP70), putative.	Heat shock protein 70 (HSP70), putative.	0.617
Q4CK86_TRYCC	Q4E175_TRYCC	Q4CK86	Q4E175	Heat shock protein 70 (HSP70), putative.	Heat shock protein 70 (HSP70), putative.	0.617
Q4CLF1_TRYCC	Q4CLV1_TRYCC	Q4CLF1	Q4CLV1	Glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative.	Transketolase, putative.	0.687
Q4CLF1_TRYCC	Q4CMZ5_TRYCC	Q4CLF1	Q4CMZ5	Glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative.	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	0.874
Q4CLF1_TRYCC	Q4CN65_TRYCC	Q4CLF1	Q4CN65	Glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative.	Phosphoglycerate kinase, putative.	0.869