(70 nodes) Mixed, incl. Terpenoid backbone biosynthesis, and Tetrapyrrole biosynthetic process network (Daphnia magna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APZ42_028796	Geranylgeranyl pyrophosphate synthase/polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (314 aa)
	APZ42_029496	3-hydroxy-3-methylglutaryl coenzyme A reductase. (868 aa)
	APZ42_028644	Solute carrier family 35 member G1. (356 aa)
	APZ42_030052	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (462 aa)
	APZ42_033024	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (332 aa)
	APZ42_011358	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (275 aa)
	APZ42_030800	Metalloendopeptidase OMA1, mitochondrial. (417 aa)
	APZ42_030708	Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (309 aa)
	APZ42_029507	Geranylgeranyl pyrophosphate synthase/polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (390 aa)
	APZ42_011354	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (270 aa)
	APZ42_014484	Solute carrier family 35 member F5. (478 aa)
	APZ42_017935	Udp-n-acetylglucosamine transporter. (351 aa)
	APZ42_016905	Hippocampus abundant transcript 1 protein. (510 aa)
	APZ42_013701	Phosphomevalonate kinase. (190 aa)
	APZ42_027442	UPF0047 protein C4A8.02c. (196 aa)
	APZ42_012433	Solute carrier family 35 member C2. (421 aa)
	APZ42_028232	Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (348 aa)
	APZ42_026039	Oxygen-dependent coproporphyrinogen-III oxidase. (390 aa)
	APZ42_020459	GDP-fucose transporter. (354 aa)
	APZ42_012885	UDP-N-acetylglucosamine transporter. (373 aa)
	EOG090X08PK	Farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha protein. (332 aa)
	APZ42_020193	Protein Churchill. (112 aa)
	APZ42_034085	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (445 aa)
	APZ42_019192	Chaperone activity of bc1 complex, mitochondrial. (675 aa)
	APZ42_026817	Solute carrier family 35 member E3. (312 aa)
	APZ42_019398	Myc box-dependent-interacting protein. (1195 aa)
	APZ42_025038	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (201 aa)
	APZ42_023823	Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. (289 aa)
	APZ42_022525	Geranylgeranyl transferase type-1 subunit beta. (363 aa)
	APZ42_011829	Nogo-B receptor. (272 aa)
	APZ42_004537	VWFA domain-containing protein. (177 aa)
	APZ42_021627	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. (407 aa)
	APZ42_015953	Isopentenyl-diphosphate Delta-isomerase 1. (222 aa)
	APZ42_015986	Uncharacterized protein. (623 aa)
	APZ42_015615	UDP-N-acetylglucosamine transporter. (332 aa)
	APZ42_015079	Uroporphyrinogen-III synthase. (189 aa)
	APZ42_014483	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (477 aa)
	APZ42_013998	CAAX prenyl protease 2. (278 aa)
	APZ42_011192	Putative Xaa-Pro dipeptidase. (367 aa)
	APZ42_011607	Porphobilinogen deaminase. (356 aa)
	APZ42_010987	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (185 aa)
	APZ42_005944	Nitrite reductase large subunit-like protein. (150 aa)
	APZ42_005862	Uncharacterized protein. (87 aa)
	APZ42_004538	Uncharacterized protein. (306 aa)
	APZ42_004390	Uncharacterized protein. (123 aa)
	APZ42_004069	AarF domain-containing protein kinase 2. (208 aa)
	APZ42_002833	Uncharacterized protein. (143 aa)
	APZ42_001960	Delta-aminolevulinic acid dehydratase-like protein. (123 aa)
	APZ42_033062	Uncharacterized protein. (417 aa)
	APZ42_031384	Farnesyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (347 aa)
	APZ42_030082	Solute carrier family 35 member B1. (372 aa)
	APZ42_029824	Protein-S-isoprenylcysteine O-methyltransferase. (314 aa)
	APZ42_029508	Decaprenyl-diphosphate synthase subunit; Belongs to the FPP/GGPP synthase family. (390 aa)
	APZ42_028635	AarF domain-containing protein kinase 1. (509 aa)
	APZ42_028634	AarF domain-containing protein kinase 1. (508 aa)
	APZ42_028782	Decaprenyl-diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family. (332 aa)
	APZ42_028799	Decaprenyl-diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family. (328 aa)
	APZ42_026040	Alkyl transferase; Belongs to the UPP synthase family. (298 aa)
	APZ42_025328	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (509 aa)
	APZ42_024456	Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. (302 aa)
	APZ42_023507	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (351 aa)
	APZ42_022287	Solute carrier family 35 member B1. (443 aa)
	APZ42_022759	Uncharacterized protein. (259 aa)
	APZ42_021140	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (381 aa)
	APZ42_019439	Optic atrophy 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (978 aa)
	APZ42_019326	Uncharacterized protein. (540 aa)
	APZ42_019077	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (355 aa)
	APZ42_017274	UDP-N-acetylglucosamine transporter. (348 aa)
	APZ42_016486	Mitochondrial thiamine pyrophosphate carrier; Belongs to the mitochondrial carrier (TC 2.A.29) family. (352 aa)
	APZ42_016261	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (276 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_001960	APZ42_010987	A0A164IM43	A0A162T7D6	Delta-aminolevulinic acid dehydratase-like protein.	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	0.515
APZ42_001960	APZ42_011607	A0A164IM43	A0A162SUT7	Delta-aminolevulinic acid dehydratase-like protein.	Porphobilinogen deaminase.	0.482
APZ42_001960	APZ42_033024	A0A164IM43	A0A0N8ECI7	Delta-aminolevulinic acid dehydratase-like protein.	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	0.512
APZ42_002833	APZ42_004069	A0A164I0E7	A0A164H9V8	Uncharacterized protein.	AarF domain-containing protein kinase 2.	0.823
APZ42_002833	APZ42_010987	A0A164I0E7	A0A162T7D6	Uncharacterized protein.	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	0.491
APZ42_002833	APZ42_011354	A0A164I0E7	A0A0P5DWE1	Uncharacterized protein.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.416
APZ42_002833	APZ42_011358	A0A164I0E7	A0A0P4WW03	Uncharacterized protein.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.416
APZ42_002833	APZ42_011607	A0A164I0E7	A0A162SUT7	Uncharacterized protein.	Porphobilinogen deaminase.	0.636
APZ42_002833	APZ42_019077	A0A164I0E7	A0A164YN61	Uncharacterized protein.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.935
APZ42_002833	APZ42_019192	A0A164I0E7	A0A0P5XNE4	Uncharacterized protein.	Chaperone activity of bc1 complex, mitochondrial.	0.823
APZ42_002833	APZ42_021627	A0A164I0E7	A0A162C9T6	Uncharacterized protein.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	0.546
APZ42_002833	APZ42_026039	A0A164I0E7	A0A0P5Q6W8	Uncharacterized protein.	Oxygen-dependent coproporphyrinogen-III oxidase.	0.561
APZ42_002833	APZ42_028634	A0A164I0E7	A0A164Q9L6	Uncharacterized protein.	AarF domain-containing protein kinase 1.	0.823
APZ42_002833	APZ42_028635	A0A164I0E7	A0A164Q9J9	Uncharacterized protein.	AarF domain-containing protein kinase 1.	0.823
APZ42_002833	APZ42_030052	A0A164I0E7	A0A0N8DCG0	Uncharacterized protein.	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.862
APZ42_002833	APZ42_033024	A0A164I0E7	A0A0N8ECI7	Uncharacterized protein.	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	0.491
APZ42_004069	APZ42_002833	A0A164H9V8	A0A164I0E7	AarF domain-containing protein kinase 2.	Uncharacterized protein.	0.823
APZ42_004069	APZ42_004390	A0A164H9V8	A0A164H399	AarF domain-containing protein kinase 2.	Uncharacterized protein.	0.689
APZ42_004069	APZ42_010987	A0A164H9V8	A0A162T7D6	AarF domain-containing protein kinase 2.	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	0.634
APZ42_004069	APZ42_011354	A0A164H9V8	A0A0P5DWE1	AarF domain-containing protein kinase 2.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.770