(43 nodes) HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), and Y-form DNA binding network (Daphnia magna)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	APZ42_018703	F-box DNA helicase 1. (949 aa)
	EOG090X0906	DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (341 aa)
	APZ42_015316	DNA repair protein RAD51. (317 aa)
	APZ42_028758	E3 ubiquitin-protein ligase RAD18. (538 aa)
	APZ42_034386	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (703 aa)
	APZ42_031507	Breast and ovarian cancer sususceptibility protein. (952 aa)
	APZ42_017653	Putative PAX-interacting protein 1. (1621 aa)
	APZ42_022013	DNA repair protein RAD52. (385 aa)
	APZ42_022277	Non-specific serine/threonine protein kinase. (2957 aa)
	APZ42_022372	ATP-dependent DNA Helicase Q5-like protein. (1046 aa)
	APZ42_011418	Replication protein A 32 kDa subunit. (268 aa)
	APZ42_017973	Meiotic recombination protein DMC1/LIM15. (358 aa)
	APZ42_032613	Replication protein A 14 kDa subunit. (111 aa)
	APZ42_014921	Microcephalin. (599 aa)
	APZ42_022932	Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. (985 aa)
	APZ42_026407	Meiotic recombination protein DMC1/LIM15. (323 aa)
	APZ42_006332	Putative DNA helicase bloom's syndrome protein A. (251 aa)
	APZ42_020612	DNA replication ATP-dependent helicase/nuclease DNA2. (765 aa)
	APZ42_026490	ATM/Rad3 and Mei-41-like protein; Belongs to the PI3/PI4-kinase family. (2568 aa)
	APZ42_015744	Ovarian-specific serine/threonine-protein kinase Lok; Belongs to the protein kinase superfamily. (429 aa)
	APZ42_015932	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (662 aa)
	APZ42_014340	Myotrophin. (770 aa)
	APZ42_013658	BRCT domain-containing protein. (1286 aa)
	APZ42_011513	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1075 aa)
	APZ42_005704	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (188 aa)
	APZ42_002389	Uncharacterized protein. (147 aa)
	APZ42_034515	DNA repair protein RAD50; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (1342 aa)
	APZ42_034246	Putative DNA helicase bloom's syndrome protein A. (1291 aa)
	APZ42_033992	Putative RecQ-mediated instability protein 1. (548 aa)
	APZ42_031140	Bloom Syndrome-like protein. (415 aa)
	APZ42_031137	Bloom Syndrome-like protein. (639 aa)
	APZ42_030620	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
	APZ42_030443	Putative Nibrin. (610 aa)
	APZ42_027254	DNA topoisomerase 2-binding protein 1. (1369 aa)
	APZ42_027299	Tudor domain-containing protein 3. (602 aa)
	APZ42_023583	DNA helicase RecQ4. (1242 aa)
	APZ42_022104	Putative Breast cancer type 2 susceptibility protein. (1569 aa)
	APZ42_021373	DNA repair protein RAD50. (157 aa)
	APZ42_019611	Putative Xeroderma pigmentosum D. (1045 aa)
	APZ42_019144	Serine/threonine-protein kinase GRP. (213 aa)
	APZ42_018837	Mutator-like protein. (1075 aa)
	APZ42_018195	Putative DNA topoisomerase 2-binding protein 1. (881 aa)
	APZ42_016194	Uncharacterized protein. (128 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_002389	APZ42_005704	A0A164IAQ3	A0A164GAW1	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.468
APZ42_002389	APZ42_006332	A0A164IAQ3	A0A162BW86	Uncharacterized protein.	Putative DNA helicase bloom's syndrome protein A.	0.890
APZ42_002389	APZ42_011513	A0A164IAQ3	A0A162SR63	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.835
APZ42_002389	APZ42_013658	A0A164IAQ3	A0A162QR19	Uncharacterized protein.	BRCT domain-containing protein.	0.656
APZ42_002389	APZ42_015316	A0A164IAQ3	A0A0N8CER2	Uncharacterized protein.	DNA repair protein RAD51.	0.732
APZ42_002389	APZ42_015932	A0A164IAQ3	A0A162NGX0	Uncharacterized protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.468
APZ42_002389	APZ42_016194	A0A164IAQ3	A0A165AJI8	Uncharacterized protein.	Uncharacterized protein.	0.424
APZ42_002389	APZ42_017653	A0A164IAQ3	A0A0N8DDI9	Uncharacterized protein.	Putative PAX-interacting protein 1.	0.862
APZ42_002389	APZ42_017973	A0A164IAQ3	A0A0P5GQW6	Uncharacterized protein.	Meiotic recombination protein DMC1/LIM15.	0.830
APZ42_002389	APZ42_018703	A0A164IAQ3	A0A0N7ZPB5	Uncharacterized protein.	F-box DNA helicase 1.	0.481
APZ42_002389	APZ42_018837	A0A164IAQ3	A0A164YVB5	Uncharacterized protein.	Mutator-like protein.	0.862
APZ42_002389	APZ42_020612	A0A164IAQ3	A0A162CC26	Uncharacterized protein.	DNA replication ATP-dependent helicase/nuclease DNA2.	0.591
APZ42_002389	APZ42_021373	A0A164IAQ3	A0A164WQS2	Uncharacterized protein.	DNA repair protein RAD50.	0.620
APZ42_002389	APZ42_022013	A0A164IAQ3	A0A0P4Y4Y5	Uncharacterized protein.	DNA repair protein RAD52.	0.936
APZ42_002389	APZ42_022372	A0A164IAQ3	A0A0P5E3J2	Uncharacterized protein.	ATP-dependent DNA Helicase Q5-like protein.	0.843
APZ42_002389	APZ42_023583	A0A164IAQ3	A0A164UTK6	Uncharacterized protein.	DNA helicase RecQ4.	0.890
APZ42_002389	APZ42_026407	A0A164IAQ3	A0A0P6IEU4	Uncharacterized protein.	Meiotic recombination protein DMC1/LIM15.	0.732
APZ42_002389	APZ42_026490	A0A164IAQ3	A0A162EDE1	Uncharacterized protein.	ATM/Rad3 and Mei-41-like protein; Belongs to the PI3/PI4-kinase family.	0.717
APZ42_002389	APZ42_027299	A0A164IAQ3	A0A164RGI7	Uncharacterized protein.	Tudor domain-containing protein 3.	0.435
APZ42_002389	APZ42_028758	A0A164IAQ3	A0A0N8CQM0	Uncharacterized protein.	E3 ubiquitin-protein ligase RAD18.	0.928