(114 nodes) Cellular response to unfolded protein network (Daphnia magna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APZ42_016110	Serine threonine-protein kinase. (290 aa)
	APZ42_016405	Protein kinase domain-containing protein. (1144 aa)
	APZ42_017849	HEAT shock 70 kDa protein cognate 5; Belongs to the heat shock protein 70 family. (613 aa)
	APZ42_018203	Uncharacterized protein. (670 aa)
	APZ42_018188	Uncharacterized protein. (752 aa)
	APZ42_020315	DnaJ protein subfamily C member. (800 aa)
	APZ42_020443	cAMP-responsive element-binding protein 3 protein 4. (594 aa)
	APZ42_020802	Putative Caspase-9; Belongs to the peptidase C14A family. (745 aa)
	APZ42_020565	Transducin beta 2 protein. (341 aa)
	APZ42_021678	Stress-associated endoplasmic reticulum protein 2. (64 aa)
	APZ42_022291	Uncharacterized protein. (852 aa)
	APZ42_023270	Uncharacterized protein. (1097 aa)
	APZ42_024315	Serine/threonine-protein kinase PDIK1L. (593 aa)
	APZ42_024256	Protein kinase domain-containing protein. (151 aa)
	APZ42_024299	Uncharacterized protein; Belongs to the protein kinase superfamily. (484 aa)
	APZ42_024217	Uncharacterized protein. (539 aa)
	APZ42_024214	Uncharacterized protein. (587 aa)
	APZ42_024219	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (309 aa)
	APZ42_024921	Protein kinase domain-containing protein. (584 aa)
	APZ42_025597	Eukaryotic translation initiation factor 2-alpha kinase. (1127 aa)
	APZ42_026194	Inhibitor of nuclear factor kappa-B kinase subunit epsilon-like protein. (777 aa)
	APZ42_026549	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (594 aa)
	APZ42_028405	Uncharacterized protein. (667 aa)
	APZ42_028633	Inositol-requiring enzyme-1-like protein. (887 aa)
	APZ42_028599	Protein kinase domain-containing protein. (331 aa)
	APZ42_029513	Serine/threonine-protein kinase/endoribonuclease IRE2. (479 aa)
	APZ42_029346	Uncharacterized protein. (768 aa)
	APZ42_029759	Uncharacterized protein. (570 aa)
	APZ42_030023	Uncharacterized protein. (718 aa)
	APZ42_030243	Uncharacterized protein; Belongs to the protein kinase superfamily. (423 aa)
	APZ42_031458	Uncharacterized protein. (440 aa)
	APZ42_032067	Uncharacterized protein. (1028 aa)
	APZ42_032062	Uncharacterized protein. (1182 aa)
	APZ42_032230	Protein kinase domain-containing protein. (638 aa)
	APZ42_033335	Serine/threonine-protein kinase 16. (731 aa)
	APZ42_034213	ATP-dependent DNA helicase; Belongs to the helicase family. (2382 aa)
	APZ42_034277	Uncharacterized protein; Belongs to the protein kinase superfamily. (489 aa)
	APZ42_001068	Protein kinase domain-containing protein. (130 aa)
	APZ42_001668	Protein kinase domain-containing protein. (221 aa)
	APZ42_002135	HEAT shock 70 kDa protein cognate 5. (129 aa)
	APZ42_004900	Uncharacterized protein. (316 aa)
	APZ42_005065	Uncharacterized protein; Belongs to the protein kinase superfamily. (367 aa)
	APZ42_005066	Uncharacterized protein. (375 aa)
	APZ42_006353	Protein kinase domain-containing protein. (398 aa)
	APZ42_007053	Protein kinase domain-containing protein. (207 aa)
	APZ42_007562	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (181 aa)
	APZ42_007611	Protein kinase domain-containing protein. (184 aa)
	APZ42_007746	Protein kinase domain-containing protein. (225 aa)
	APZ42_007851	Protein kinase domain-containing protein. (366 aa)
	APZ42_007861	Protein kinase domain-containing protein. (184 aa)
	APZ42_007877	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (252 aa)
	APZ42_008389	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (443 aa)
	APZ42_011139	Rhomboid-related protein 4. (312 aa)
	APZ42_011719	Uncharacterized protein; Belongs to the peptidase C14A family. (1168 aa)
	APZ42_011731	Putative Caspase-1; Belongs to the peptidase C14A family. (613 aa)
	APZ42_011555	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin domain member 2-like protein. (384 aa)
	APZ42_011247	Serine/threonine-protein kinase/endoribonuclease IRE2. (1597 aa)
	APZ42_011863	Lymphokine-activated killer T-cell-originated protein kinase. (821 aa)
	APZ42_012485	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (277 aa)
	APZ42_012508	Uncharacterized protein. (1135 aa)
	APZ42_012482	Uncharacterized protein. (782 aa)
	APZ42_013663	Glucosylceramidase. (516 aa)
	APZ42_015375	BAX inhibitor 1; Belongs to the BI1 family. (244 aa)
	APZ42_015309	Putative X-box-binding protein. (345 aa)
	APZ42_015048	Putative Serine/threonine-protein kinase/endoribonuclease IRE2. (406 aa)
	APZ42_014854	Uncharacterized protein. (714 aa)
	APZ42_016168	Protein kinase domain-containing protein. (289 aa)
	APZ42_016161	Protein kinase domain-containing protein. (226 aa)
	APZ42_016106	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (282 aa)
	APZ42_016012	Protein kinase domain-containing protein. (250 aa)
	APZ42_016014	Protein kinase domain-containing protein. (271 aa)
	APZ42_015793	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (261 aa)
	APZ42_015816	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (446 aa)
	APZ42_008075	Protein kinase domain-containing protein. (282 aa)
	APZ42_026555	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (344 aa)
	APZ42_030753	Poly [ADP-ribose] polymerase. (315 aa)
	APZ42_001667	Protein kinase domain-containing protein. (220 aa)
	APZ42_004347	Uncharacterized protein; Belongs to the protein kinase superfamily. (487 aa)
	APZ42_008288	Uncharacterized protein. (331 aa)
	APZ42_008228	Calcium/calmodulin-dependent protein kinase kinase; Belongs to the protein kinase superfamily. (308 aa)
	APZ42_027673	Serine threonine-protein kinase. (694 aa)
	APZ42_031216	Serine threonine-protein kinase. (906 aa)
	APZ42_028593	Serine/threonine-protein kinase SBK1; Belongs to the protein kinase superfamily. (452 aa)
	APZ42_015746	Uncharacterized protein. (685 aa)
	APZ42_024210	Putative Serine threonine-protein kinase. (534 aa)
	APZ42_030957	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (1066 aa)
	APZ42_011329	HEAT shock 70 kDa protein cognate 4; Belongs to the heat shock protein 70 family. (659 aa)
	APZ42_031761	Heat shock protein 75 kDa, mitochondrial. (691 aa)
	APZ42_028516	Uncharacterized protein; Belongs to the protein kinase superfamily. (483 aa)
	APZ42_016113	Serine threonine-protein kinase; Belongs to the protein kinase superfamily. (424 aa)
	APZ42_016364	Eukaryotic translation initiation factor 2-alpha kinase 3-like protein. (535 aa)
	APZ42_034295	60 kDa heat shock protein, mitochondrial; Belongs to the chaperonin (HSP60) family. (576 aa)
	APZ42_031953	Endoplasmic reticulum lectin 1. (537 aa)
	APZ42_027637	Glucosylceramidase. (519 aa)
	APZ42_016112	Serine threonine-protein kinase. (277 aa)
	APZ42_016111	Serine threonine-protein kinase. (268 aa)
	APZ42_029247	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (253 aa)
	APZ42_020989	Transmembrane 7 superfamily member 3. (555 aa)
	APZ42_010897	Cyclic AMP-dependent transcription factor ATF-6 alpha. (695 aa)
	APZ42_011691	Uncharacterized protein; Belongs to the peptidase C14A family. (665 aa)
	EOG090X03TK	E3 ubiquitin-protein ligase synoviolin. (569 aa)
	APZ42_016098	Kinase c delta type. (287 aa)
	APZ42_017792	Putative Caspase Dronc; Belongs to the peptidase C14A family. (658 aa)
	APZ42_016109	Serine/threonine protein kinase. (299 aa)
	APZ42_013662	Glucosylceramidase. (538 aa)
	APZ42_028701	Serine threonine-protein kinase. (592 aa)
	APZ42_016150	Calcium/calmodulin-dependent protein kinase kinase; Belongs to the protein kinase superfamily. (275 aa)
	APZ42_016160	Calcium/calmodulin-dependent protein kinase kinase; Belongs to the protein kinase superfamily. (292 aa)
	APZ42_016115	Calcium/calmodulin-dependent protein kinase kinase; Belongs to the protein kinase superfamily. (297 aa)
	APZ42_016084	Minor histocompatibility antigen H13. (362 aa)
	APZ42_011945	Protein kinase domain-containing protein. (101 aa)
	APZ42_020174	Putative Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase. (633 aa)
	APZ42_025278	Putative Serine threonine-protein kinase. (852 aa)
	APZ42_016762	Wolfram syndrome 1. (887 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_001068	APZ42_010897	A0A164J6X8	A0A0P5SXF8	Protein kinase domain-containing protein.	Cyclic AMP-dependent transcription factor ATF-6 alpha.	0.523
APZ42_001068	APZ42_011329	A0A164J6X8	A0A0P5ZG64	Protein kinase domain-containing protein.	HEAT shock 70 kDa protein cognate 4; Belongs to the heat shock protein 70 family.	0.713
APZ42_001068	APZ42_015309	A0A164J6X8	A0A162PCP8	Protein kinase domain-containing protein.	Putative X-box-binding protein.	0.542
APZ42_001667	APZ42_010897	A0A162D034	A0A0P5SXF8	Protein kinase domain-containing protein.	Cyclic AMP-dependent transcription factor ATF-6 alpha.	0.523
APZ42_001667	APZ42_011329	A0A162D034	A0A0P5ZG64	Protein kinase domain-containing protein.	HEAT shock 70 kDa protein cognate 4; Belongs to the heat shock protein 70 family.	0.713
APZ42_001667	APZ42_015309	A0A162D034	A0A162PCP8	Protein kinase domain-containing protein.	Putative X-box-binding protein.	0.547
APZ42_001667	APZ42_016364	A0A162D034	A0A0P5XFU1	Protein kinase domain-containing protein.	Eukaryotic translation initiation factor 2-alpha kinase 3-like protein.	0.594
APZ42_001667	APZ42_020174	A0A162D034	A0A0N8DB68	Protein kinase domain-containing protein.	Putative Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase.	0.538
APZ42_001668	APZ42_010897	A0A164IU77	A0A0P5SXF8	Protein kinase domain-containing protein.	Cyclic AMP-dependent transcription factor ATF-6 alpha.	0.523
APZ42_001668	APZ42_011329	A0A164IU77	A0A0P5ZG64	Protein kinase domain-containing protein.	HEAT shock 70 kDa protein cognate 4; Belongs to the heat shock protein 70 family.	0.713
APZ42_001668	APZ42_015309	A0A164IU77	A0A162PCP8	Protein kinase domain-containing protein.	Putative X-box-binding protein.	0.547
APZ42_001668	APZ42_016364	A0A164IU77	A0A0P5XFU1	Protein kinase domain-containing protein.	Eukaryotic translation initiation factor 2-alpha kinase 3-like protein.	0.594
APZ42_001668	APZ42_020174	A0A164IU77	A0A0N8DB68	Protein kinase domain-containing protein.	Putative Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase.	0.538
APZ42_002135	APZ42_010897	A0A164IHF4	A0A0P5SXF8	HEAT shock 70 kDa protein cognate 5.	Cyclic AMP-dependent transcription factor ATF-6 alpha.	0.596
APZ42_002135	APZ42_011329	A0A164IHF4	A0A0P5ZG64	HEAT shock 70 kDa protein cognate 5.	HEAT shock 70 kDa protein cognate 4; Belongs to the heat shock protein 70 family.	0.780
APZ42_002135	APZ42_016364	A0A164IHF4	A0A0P5XFU1	HEAT shock 70 kDa protein cognate 5.	Eukaryotic translation initiation factor 2-alpha kinase 3-like protein.	0.602
APZ42_002135	APZ42_016405	A0A164IHF4	A0A165AEY2	HEAT shock 70 kDa protein cognate 5.	Protein kinase domain-containing protein.	0.602
APZ42_002135	APZ42_020174	A0A164IHF4	A0A0N8DB68	HEAT shock 70 kDa protein cognate 5.	Putative Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase.	0.602
APZ42_002135	APZ42_020315	A0A164IHF4	A0A164XM53	HEAT shock 70 kDa protein cognate 5.	DnaJ protein subfamily C member.	0.936
APZ42_002135	APZ42_025597	A0A164IHF4	A0A164SX53	HEAT shock 70 kDa protein cognate 5.	Eukaryotic translation initiation factor 2-alpha kinase.	0.602