(43 nodes) ERAD pathway network (Daphnia magna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APZ42_028169	RING finger protein 145. (748 aa)
	APZ42_029436	J domain-containing protein. (134 aa)
	APZ42_030315	E3 ubiquitin-protein ligase RNF185. (191 aa)
	APZ42_032565	Putative Ubiquitin-conjugating enzyme E2 J1. (255 aa)
	APZ42_033669	JNK1/MAPK8-associated membrane protein. (339 aa)
	APZ42_034375	26S Protease regulatory subunit 10B; Belongs to the AAA ATPase family. (389 aa)
	APZ42_000771	Ubiquitin fusion degradation protein 1. (86 aa)
	APZ42_008911	Ubiquitin fusion degradation protein 1. (122 aa)
	APZ42_011139	Rhomboid-related protein 4. (312 aa)
	APZ42_012135	XK-related protein. (1283 aa)
	APZ42_012975	Ubiquitin conjugation factor E4 A. (982 aa)
	APZ42_015087	Ancient ubiquitous protein 1. (432 aa)
	APZ42_015793	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (261 aa)
	APZ42_017676	RING finger protein 121. (305 aa)
	APZ42_030957	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (1066 aa)
	APZ42_011329	HEAT shock 70 kDa protein cognate 4; Belongs to the heat shock protein 70 family. (659 aa)
	APZ42_023581	FAS-associated factor 1. (665 aa)
	APZ42_020002	DnaJ subfamily B member 12. (370 aa)
	APZ42_024557	E3 ubiquitin-protein ligase RNF103. (435 aa)
	APZ42_016086	Sel-1. (778 aa)
	APZ42_019355	Heat shock protein HSP 90-alpha. (788 aa)
	APZ42_024577	UDP-glucose:glycoprotein glucosyltransferase. (1508 aa)
	APZ42_031953	Endoplasmic reticulum lectin 1. (537 aa)
	APZ42_026852	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (594 aa)
	APZ42_029247	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family. (253 aa)
	EOG090X03TK	E3 ubiquitin-protein ligase synoviolin. (569 aa)
	APZ42_021695	Ubiquitin thioesterase OTU1. (311 aa)
	APZ42_018479	E3 ubiquitin-protein ligase MARCH6. (930 aa)
	APZ42_028966	UBX domain-containing protein 4. (453 aa)
	APZ42_029534	Putative Ubiquitin conjugation factor E4 A. (1068 aa)
	APZ42_028779	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (614 aa)
	APZ42_011342	E3 ubiquitin-protein ligase RNF139. (684 aa)
	APZ42_011690	FAM8A1 protein. (266 aa)
	APZ42_027035	Proteasome-associated protein ECM29. (1786 aa)
	APZ42_000772	Ubiquitin-conjugating enzyme E2 J2. (237 aa)
	APZ42_017866	Putative Small glutamine-rich tetratricopeptide repeat-containing protein alpha. (314 aa)
	APZ42_016504	F-box only protein 2. (276 aa)
	APZ42_020315	DnaJ protein subfamily C member. (800 aa)
	APZ42_022190	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (207 aa)
	APZ42_022859	UV excision repair RAD23 A-like protein. (1159 aa)
	APZ42_022982	FAS-associated factor 2-B. (466 aa)
	APZ42_026549	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (594 aa)
	APZ42_028157	Calnexin. (588 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_000771	APZ42_011342	A0A164JE78	A0A0P5DXJ9	Ubiquitin fusion degradation protein 1.	E3 ubiquitin-protein ligase RNF139.	0.490
APZ42_000771	APZ42_012135	A0A164JE78	A0A162S5V2	Ubiquitin fusion degradation protein 1.	XK-related protein.	0.534
APZ42_000771	APZ42_012975	A0A164JE78	A0A162RAS4	Ubiquitin fusion degradation protein 1.	Ubiquitin conjugation factor E4 A.	0.903
APZ42_000771	APZ42_015793	A0A164JE78	A0A162NB43	Ubiquitin fusion degradation protein 1.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.948
APZ42_000771	APZ42_016086	A0A164JE78	A0A0P5Z7N7	Ubiquitin fusion degradation protein 1.	Sel-1.	0.424
APZ42_000771	APZ42_018479	A0A164JE78	A0A0P5QJ04	Ubiquitin fusion degradation protein 1.	E3 ubiquitin-protein ligase MARCH6.	0.536
APZ42_000771	APZ42_021695	A0A164JE78	A0A0P5S8Z6	Ubiquitin fusion degradation protein 1.	Ubiquitin thioesterase OTU1.	0.952
APZ42_000771	APZ42_022190	A0A164JE78	A0A164W3N5	Ubiquitin fusion degradation protein 1.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.410
APZ42_000771	APZ42_022982	A0A164JE78	A0A164VCX0	Ubiquitin fusion degradation protein 1.	FAS-associated factor 2-B.	0.980
APZ42_000771	APZ42_023581	A0A164JE78	A0A0P5ZCT5	Ubiquitin fusion degradation protein 1.	FAS-associated factor 1.	0.982
APZ42_000771	APZ42_028169	A0A164JE78	A0A164QJE8	Ubiquitin fusion degradation protein 1.	RING finger protein 145.	0.467
APZ42_000771	APZ42_029247	A0A164JE78	A0A0P5U053	Ubiquitin fusion degradation protein 1.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.960
APZ42_000771	APZ42_029534	A0A164JE78	A0A0P5FB11	Ubiquitin fusion degradation protein 1.	Putative Ubiquitin conjugation factor E4 A.	0.903
APZ42_000771	APZ42_031953	A0A164JE78	A0A0P5WAY6	Ubiquitin fusion degradation protein 1.	Endoplasmic reticulum lectin 1.	0.416
APZ42_000771	APZ42_032565	A0A164JE78	A0A164LN33	Ubiquitin fusion degradation protein 1.	Putative Ubiquitin-conjugating enzyme E2 J1.	0.405
APZ42_000771	APZ42_034375	A0A164JE78	A0A164K4A0	Ubiquitin fusion degradation protein 1.	26S Protease regulatory subunit 10B; Belongs to the AAA ATPase family.	0.714
APZ42_000771	EOG090X03TK	A0A164JE78	A0A0P5S985	Ubiquitin fusion degradation protein 1.	E3 ubiquitin-protein ligase synoviolin.	0.682
APZ42_000772	APZ42_015793	A0A0N8DD59	A0A162NB43	Ubiquitin-conjugating enzyme E2 J2.	Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.	0.735
APZ42_000772	APZ42_016086	A0A0N8DD59	A0A0P5Z7N7	Ubiquitin-conjugating enzyme E2 J2.	Sel-1.	0.408
APZ42_000772	APZ42_017866	A0A0N8DD59	A0A0N8C3W3	Ubiquitin-conjugating enzyme E2 J2.	Putative Small glutamine-rich tetratricopeptide repeat-containing protein alpha.	0.825