(15 nodes) Telomeric DNA binding network (Daphnia magna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APZ42_011474	TM2 domain-containing protein almondex. (211 aa)
	APZ42_032559	X-ray repair cross-complementing protein 6. (251 aa)
	APZ42_013658	BRCT domain-containing protein. (1286 aa)
	APZ42_011196	Protein SMG5. (807 aa)
	APZ42_034515	DNA repair protein RAD50; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (1342 aa)
	APZ42_030620	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
	APZ42_029243	Uncharacterized protein. (1185 aa)
	APZ42_028745	Uncharacterized protein. (1018 aa)
	APZ42_023915	Uncharacterized protein. (938 aa)
	APZ42_021373	DNA repair protein RAD50. (157 aa)
	APZ42_017350	TPR_REGION domain-containing protein. (705 aa)
	APZ42_018475	X-ray repair cross-complementing protein 5. (122 aa)
	APZ42_028622	Putative Telomerase-binding protein EST1A. (1755 aa)
	APZ42_001454	Putative Oligonucleotide/oligosaccharide-binding fold-containing protein 1/sw. (194 aa)
	APZ42_034087	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1082 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_001454	APZ42_013658	A0A0P5XRM9	A0A162QR19	Putative Oligonucleotide/oligosaccharide-binding fold-containing protein 1/sw.	BRCT domain-containing protein.	0.433
APZ42_001454	APZ42_021373	A0A0P5XRM9	A0A164WQS2	Putative Oligonucleotide/oligosaccharide-binding fold-containing protein 1/sw.	DNA repair protein RAD50.	0.541
APZ42_001454	APZ42_023915	A0A0P5XRM9	A0A164U9R5	Putative Oligonucleotide/oligosaccharide-binding fold-containing protein 1/sw.	Uncharacterized protein.	0.993
APZ42_001454	APZ42_028745	A0A0P5XRM9	A0A164QBR0	Putative Oligonucleotide/oligosaccharide-binding fold-containing protein 1/sw.	Uncharacterized protein.	0.786
APZ42_001454	APZ42_030620	A0A0P5XRM9	A0A164NPL0	Putative Oligonucleotide/oligosaccharide-binding fold-containing protein 1/sw.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.927
APZ42_001454	APZ42_032559	A0A0P5XRM9	A0A162D8N2	Putative Oligonucleotide/oligosaccharide-binding fold-containing protein 1/sw.	X-ray repair cross-complementing protein 6.	0.599
APZ42_001454	APZ42_034515	A0A0P5XRM9	A0A164K1V3	Putative Oligonucleotide/oligosaccharide-binding fold-containing protein 1/sw.	DNA repair protein RAD50; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.541
APZ42_011196	APZ42_017350	A0A162SHG2	A0A164ZTN2	Protein SMG5.	TPR_REGION domain-containing protein.	0.919
APZ42_011196	APZ42_018475	A0A162SHG2	A0A164Z2S1	Protein SMG5.	X-ray repair cross-complementing protein 5.	0.656
APZ42_011196	APZ42_028622	A0A162SHG2	A0A0P5ANQ7	Protein SMG5.	Putative Telomerase-binding protein EST1A.	0.942
APZ42_011196	APZ42_032559	A0A162SHG2	A0A162D8N2	Protein SMG5.	X-ray repair cross-complementing protein 6.	0.620
APZ42_011196	APZ42_034087	A0A162SHG2	A0A0P6A2E9	Protein SMG5.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.	0.896
APZ42_011474	APZ42_028745	A0A162CZB4	A0A164QBR0	TM2 domain-containing protein almondex.	Uncharacterized protein.	0.600
APZ42_013658	APZ42_001454	A0A162QR19	A0A0P5XRM9	BRCT domain-containing protein.	Putative Oligonucleotide/oligosaccharide-binding fold-containing protein 1/sw.	0.433
APZ42_013658	APZ42_018475	A0A162QR19	A0A164Z2S1	BRCT domain-containing protein.	X-ray repair cross-complementing protein 5.	0.851
APZ42_013658	APZ42_021373	A0A162QR19	A0A164WQS2	BRCT domain-containing protein.	DNA repair protein RAD50.	0.737
APZ42_013658	APZ42_030620	A0A162QR19	A0A164NPL0	BRCT domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.809
APZ42_013658	APZ42_032559	A0A162QR19	A0A162D8N2	BRCT domain-containing protein.	X-ray repair cross-complementing protein 6.	0.976
APZ42_013658	APZ42_034515	A0A162QR19	A0A164K1V3	BRCT domain-containing protein.	DNA repair protein RAD50; Belongs to the ligand-gated ion channel (TC 1.A.9) family.	0.737
APZ42_017350	APZ42_011196	A0A164ZTN2	A0A162SHG2	TPR_REGION domain-containing protein.	Protein SMG5.	0.919