(86 nodes) Positive regulation of MAPK cascade network (Daphnia magna)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APZ42_016548	Protein kinase domain-containing protein. (927 aa)
	APZ42_024062	Cylindromatosis. (777 aa)
	APZ42_024303	Putative Inactive tyrosine-protein kinase 7. (1141 aa)
	APZ42_023578	Dedicator of cytokinesis protein 5; Belongs to the DOCK family. (2046 aa)
	APZ42_023063	SH2B adapter protein 3. (577 aa)
	APZ42_022990	Chromatin accessibility complex 14kD protein. (209 aa)
	APZ42_022330	Guanine nucleotide exchange factor VAV3. (805 aa)
	APZ42_022369	MAP kinase-activating death domain protein. (1753 aa)
	APZ42_021685	Tyrosine-protein kinase JAK1. (1217 aa)
	APZ42_021254	TNF receptor-associated factor 4. (118 aa)
	APZ42_020054	Putative Vascular endothelial growth factor receptor 3. (1011 aa)
	APZ42_020123	Protein kinase domain-containing protein. (468 aa)
	APZ42_020116	Putative Receptor-type tyrosine-protein kinase FLT3. (791 aa)
	APZ42_020161	Putative Vascular endothelial growth factor receptor 1. (994 aa)
	APZ42_020156	Protein kinase domain-containing protein. (1515 aa)
	APZ42_020225	Receptor protein-tyrosine kinase. (1213 aa)
	APZ42_019443	Enhancer of sevenless 2B protein. (211 aa)
	APZ42_018316	Tyrosine-protein kinase receptor. (1330 aa)
	APZ42_017332	Putative ATP-dependent RNA Helicase DHX33. (665 aa)
	APZ42_013207	Menin. (677 aa)
	APZ42_017495	Dopamine/Ecdysteroid receptor. (387 aa)
	APZ42_025525	Putative Class c scavenger receptor sushi/scr/ccp. (145 aa)
	APZ42_020174	Putative Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase. (633 aa)
	APZ42_014202	BTB domain-containing protein. (254 aa)
	APZ42_017278	Uncharacterized protein. (582 aa)
	APZ42_019333	Sprouty. (464 aa)
	APZ42_025380	Guanine nucleotide exchange factor VAV2. (546 aa)
	APZ42_012106	C-Jun-amino-terminal kinase-interacting protein. (430 aa)
	APZ42_015145	Striatin-3. (780 aa)
	APZ42_033264	Ragulator complex protein LAMTOR1. (171 aa)
	EOG090X02BW	Engulfment and cell motility protein 3. (736 aa)
	APZ42_026226	PRA1 family protein. (189 aa)
	APZ42_011343	Rho GTPase-activating protein 68F. (483 aa)
	APZ42_019982	Btb/poz domain-containing protein. (322 aa)
	APZ42_016364	Eukaryotic translation initiation factor 2-alpha kinase 3-like protein. (535 aa)
	APZ42_022107	Putative SH3 domain-containing RING finger protein 3. (805 aa)
	APZ42_023498	Putative Jelly Belly. (477 aa)
	APZ42_018666	Putative Cytohesin-1. (589 aa)
	APZ42_022687	Dual specificity mitogen-activated protein kinase kinase. (803 aa)
	APZ42_032372	Receptor protein-tyrosine kinase. (1457 aa)
	APZ42_028368	5-hydroxytryptamine receptor 2B; Belongs to the G-protein coupled receptor 1 family. (634 aa)
	APZ42_029439	GH16255p. (205 aa)
	APZ42_013520	Sptzle 1B. (218 aa)
	APZ42_015555	Cerebral cavernous malformation 3. (212 aa)
	APZ42_030312	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (758 aa)
	APZ42_019921	Protein kinase domain-containing protein. (749 aa)
	APZ42_019958	Uncharacterized protein. (933 aa)
	APZ42_005717	BTB domain-containing protein. (141 aa)
	APZ42_011380	Ubiquitin carboxyl-terminal hydrolase 47; Belongs to the peptidase C19 family. (1402 aa)
	APZ42_029018	BTB domain-containing protein. (294 aa)
	APZ42_028096	Uncharacterized protein. (550 aa)
	APZ42_031764	Protein kinase at 92B. (1374 aa)
	APZ42_008075	Protein kinase domain-containing protein. (282 aa)
	APZ42_014173	Uncharacterized protein. (563 aa)
	APZ42_013897	Uncharacterized protein. (743 aa)
	EOG090X0I8J	Ubiquitin-conjugating enzyme E2 variant 2. (147 aa)
	APZ42_012425	Kinase suppressor of Ras 1. (978 aa)
	APZ42_011884	ALG-2 interacting protein X. (813 aa)
	APZ42_011221	cAMP-specific 3',5'-cyclic phosphodiesterase 7B; Belongs to the cyclic nucleotide phosphodiesterase family. (995 aa)
	APZ42_008239	Programmed cell death 6-interacting protein. (363 aa)
	APZ42_007372	Putative MAP kinase-activating death domain protein. (148 aa)
	APZ42_004793	Uncharacterized protein. (299 aa)
	APZ42_002734	Pro-neuregulin-2, membrane-bound. (63 aa)
	APZ42_000652	Uncharacterized protein. (215 aa)
	APZ42_033777	TNF receptor-associated factor 4. (359 aa)
	APZ42_032195	Pro-neuregulin-2, membrane-bound-like protein. (466 aa)
	APZ42_031428	Programmed cell death protein 6. (184 aa)
	APZ42_030789	Ras-related protein Rap-1B. (131 aa)
	APZ42_030507	Pre-mRNA-splicing factor ATP-dependent RNA Helicase DHX15. (734 aa)
	APZ42_030510	Mekk1. (1578 aa)
	APZ42_029542	Mast/stem cell growth factor receptor Kit. (903 aa)
	APZ42_028700	Mitogen-activated protein kinase kinase kinase kinase. (382 aa)
	APZ42_028482	ATP-dependent RNA Helicase DHX33. (229 aa)
	APZ42_028093	Uncharacterized protein. (619 aa)
	APZ42_027346	Uncharacterized protein. (602 aa)
	APZ42_026972	C-Jun-amino-terminal kinase-interacting protein 3. (1396 aa)
	APZ42_026127	Serine/threonine-protein kinase mos. (234 aa)
	APZ42_026107	Raf serine/threonine-protein kinase phl. (913 aa)
	APZ42_025854	Uncharacterized protein. (884 aa)
	APZ42_025597	Eukaryotic translation initiation factor 2-alpha kinase. (1127 aa)
	APZ42_025382	Vav protein. (172 aa)
	APZ42_025275	Putative Connector enhancer of kinase suppressor of ras 1. (1857 aa)
	APZ42_025128	Dedicator of cytokinesis protein 5; Belongs to the DOCK family. (2017 aa)
	APZ42_024810	BTB domain-containing protein. (399 aa)
	APZ42_024459	Tyrosine-protein kinase receptor. (773 aa)
	APZ42_024409	Roadkill protein. (340 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_000652	APZ42_013520	A0A164JH90	A0A0P6FSD2	Uncharacterized protein.	Sptzle 1B.	0.509
APZ42_000652	APZ42_018316	A0A164JH90	A0A164Z3T8	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.546
APZ42_000652	APZ42_019443	A0A164JH90	A0A164Y7E8	Uncharacterized protein.	Enhancer of sevenless 2B protein.	0.701
APZ42_000652	APZ42_024459	A0A164JH90	A0A164U100	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.568
APZ42_000652	APZ42_030789	A0A164JH90	A0A164NC55	Uncharacterized protein.	Ras-related protein Rap-1B.	0.509
APZ42_002734	APZ42_013520	A0A164I2R4	A0A0P6FSD2	Pro-neuregulin-2, membrane-bound.	Sptzle 1B.	0.522
APZ42_002734	APZ42_019443	A0A164I2R4	A0A164Y7E8	Pro-neuregulin-2, membrane-bound.	Enhancer of sevenless 2B protein.	0.627
APZ42_002734	APZ42_030789	A0A164I2R4	A0A164NC55	Pro-neuregulin-2, membrane-bound.	Ras-related protein Rap-1B.	0.522
APZ42_004793	APZ42_012106	A0A164GUB4	A0A0P5D8G0	Uncharacterized protein.	C-Jun-amino-terminal kinase-interacting protein.	0.721
APZ42_004793	APZ42_013520	A0A164GUB4	A0A0P6FSD2	Uncharacterized protein.	Sptzle 1B.	0.595
APZ42_004793	APZ42_016364	A0A164GUB4	A0A0P5XFU1	Uncharacterized protein.	Eukaryotic translation initiation factor 2-alpha kinase 3-like protein.	0.520
APZ42_004793	APZ42_016548	A0A164GUB4	A0A165AHT4	Uncharacterized protein.	Protein kinase domain-containing protein.	0.900
APZ42_004793	APZ42_018316	A0A164GUB4	A0A164Z3T8	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.553
APZ42_004793	APZ42_019443	A0A164GUB4	A0A164Y7E8	Uncharacterized protein.	Enhancer of sevenless 2B protein.	0.644
APZ42_004793	APZ42_020174	A0A164GUB4	A0A0N8DB68	Uncharacterized protein.	Putative Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase.	0.520
APZ42_004793	APZ42_021254	A0A164GUB4	A0A164WU47	Uncharacterized protein.	TNF receptor-associated factor 4.	0.622
APZ42_004793	APZ42_022107	A0A164GUB4	A0A0P5YEQ6	Uncharacterized protein.	Putative SH3 domain-containing RING finger protein 3.	0.539
APZ42_004793	APZ42_022330	A0A164GUB4	A0A164VER6	Uncharacterized protein.	Guanine nucleotide exchange factor VAV3.	0.620
APZ42_004793	APZ42_022687	A0A164GUB4	A0A0P5ZN54	Uncharacterized protein.	Dual specificity mitogen-activated protein kinase kinase.	0.854
APZ42_004793	APZ42_023063	A0A164GUB4	A0A164V8X3	Uncharacterized protein.	SH2B adapter protein 3.	0.569