(47 nodes) Response to peptide hormone network (Daphnia magna)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APZ42_015220	Phosphatidate phosphatase LPIN1. (947 aa)
	APZ42_014785	Myc, dMyc-like protein. (178 aa)
	APZ42_014158	Eukaryotic translation initiation factor 4E-binding protein 2. (133 aa)
	APZ42_014162	Putative Histone deacetylase silent information regulator protein Sir2. (600 aa)
	APZ42_013831	Non-specific serine/threonine protein kinase. (532 aa)
	APZ42_013130	Phosphatidylinositol 3-kinase catalytic subunit type 3; Belongs to the PI3/PI4-kinase family. (1116 aa)
	APZ42_013134	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit Delta; Belongs to the PI3/PI4-kinase family. (658 aa)
	DmagArnt2	Aryl hydrocarbone receptor nuclear translocator. (668 aa)
	APZ42_016243	Ketohexokinase. (309 aa)
	APZ42_016447	Insulin receptor substrate 1-like protein. (1672 aa)
	APZ42_016906	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (205 aa)
	APZ42_019443	Enhancer of sevenless 2B protein. (211 aa)
	APZ42_020436	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (845 aa)
	APZ42_021359	Transcription factor HNF-4. (544 aa)
	APZ42_021472	Regulatory-associated protein of mTOR. (341 aa)
	APZ42_022381	No child left behind. (493 aa)
	APZ42_022288	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (227 aa)
	APZ42_022951	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (207 aa)
	APZ42_023063	SH2B adapter protein 3. (577 aa)
	APZ42_024029	Phosphatidylinositol 3-kinase regulatory subunit gamma. (409 aa)
	APZ42_023798	Pi3K21B. (782 aa)
	APZ42_025275	Putative Connector enhancer of kinase suppressor of ras 1. (1857 aa)
	APZ42_026502	GTP-binding protein Rheb. (185 aa)
	APZ42_026543	Peroxisome proliferator-activated receptor gamma coactivator-related-like protein. (511 aa)
	APZ42_029280	Putative Endoplasmic reticulum-Golgi intermediate compartment protein 2. (936 aa)
	APZ42_032941	Uncharacterized protein. (525 aa)
	APZ42_034436	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2457 aa)
	APZ42_001659	Tyrosine-protein kinase receptor. (151 aa)
	APZ42_001925	Putative Lambda-crystallin. (169 aa)
	APZ42_001998	Putative Trifunctional enzyme subunit alpha. (108 aa)
	APZ42_012419	TLD domain-containing protein 1. (448 aa)
	APZ42_012789	Putative Serine/threonine-protein kinase QSK. (613 aa)
	APZ42_017455	Target of rapamycin complex 2 subunit MAPKAP1. (430 aa)
	APZ42_015040	Phosphoinositide phospholipase C. (1294 aa)
	APZ42_015829	Tyrosine-protein kinase receptor. (1304 aa)
	APZ42_015832	Tyrosine-protein kinase receptor. (1310 aa)
	APZ42_030256	Otopetrin-3. (902 aa)
	APZ42_011195	Regulatory-associated protein of mTOR. (911 aa)
	APZ42_023626	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (509 aa)
	APZ42_015990	Dual specificity mitogen-activated protein kinase kinase dSOR1; Belongs to the protein kinase superfamily. (431 aa)
	APZ42_020282	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1140 aa)
	APZ42_002931	SAM domain-containing protein. (59 aa)
	APZ42_001903	Protein BTG4. (207 aa)
	APZ42_012948	Putative Hypoxia inducible factor-1 alpha. (440 aa)
	APZ42_016805	3-phosphoinositide-dependent protein kinase. (511 aa)
	APZ42_015992	Uncharacterized protein. (1040 aa)
	APZ42_014980	Putative Hypoxia inducible factor-1 alpha. (319 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_001659	APZ42_002931	A0A164IUD0	A0A162C3Y1	Tyrosine-protein kinase receptor.	SAM domain-containing protein.	0.809
APZ42_001659	APZ42_011195	A0A164IUD0	A0A162CYR5	Tyrosine-protein kinase receptor.	Regulatory-associated protein of mTOR.	0.569
APZ42_001659	APZ42_013130	A0A164IUD0	A0A162R1L1	Tyrosine-protein kinase receptor.	Phosphatidylinositol 3-kinase catalytic subunit type 3; Belongs to the PI3/PI4-kinase family.	0.743
APZ42_001659	APZ42_013134	A0A164IUD0	A0A162R1M2	Tyrosine-protein kinase receptor.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit Delta; Belongs to the PI3/PI4-kinase family.	0.743
APZ42_001659	APZ42_014785	A0A164IUD0	A0A162PLP0	Tyrosine-protein kinase receptor.	Myc, dMyc-like protein.	0.411
APZ42_001659	APZ42_015040	A0A164IUD0	A0A0P5Y732	Tyrosine-protein kinase receptor.	Phosphoinositide phospholipase C.	0.680
APZ42_001659	APZ42_015990	A0A164IUD0	A0A0P5CCC7	Tyrosine-protein kinase receptor.	Dual specificity mitogen-activated protein kinase kinase dSOR1; Belongs to the protein kinase superfamily.	0.662
APZ42_001659	APZ42_016447	A0A164IUD0	A0A165AFH6	Tyrosine-protein kinase receptor.	Insulin receptor substrate 1-like protein.	0.962
APZ42_001659	APZ42_016805	A0A164IUD0	A0A0P5NQ39	Tyrosine-protein kinase receptor.	3-phosphoinositide-dependent protein kinase.	0.637
APZ42_001659	APZ42_019443	A0A164IUD0	A0A164Y7E8	Tyrosine-protein kinase receptor.	Enhancer of sevenless 2B protein.	0.750
APZ42_001659	APZ42_020436	A0A164IUD0	A0A164XHS0	Tyrosine-protein kinase receptor.	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	0.632
APZ42_001659	APZ42_021472	A0A164IUD0	A0A164WMN8	Tyrosine-protein kinase receptor.	Regulatory-associated protein of mTOR.	0.569
APZ42_001659	APZ42_022951	A0A164IUD0	A0A164VB60	Tyrosine-protein kinase receptor.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.589
APZ42_001659	APZ42_023063	A0A164IUD0	A0A164V8X3	Tyrosine-protein kinase receptor.	SH2B adapter protein 3.	0.870
APZ42_001659	APZ42_023626	A0A164IUD0	A0A0P5G770	Tyrosine-protein kinase receptor.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.479
APZ42_001659	APZ42_023798	A0A164IUD0	A0A164U5D2	Tyrosine-protein kinase receptor.	Pi3K21B.	0.809
APZ42_001659	APZ42_024029	A0A164IUD0	A0A164UD32	Tyrosine-protein kinase receptor.	Phosphatidylinositol 3-kinase regulatory subunit gamma.	0.809
APZ42_001659	APZ42_025275	A0A164IUD0	A0A164T971	Tyrosine-protein kinase receptor.	Putative Connector enhancer of kinase suppressor of ras 1.	0.576
APZ42_001659	APZ42_026502	A0A164IUD0	A0A164S9X2	Tyrosine-protein kinase receptor.	GTP-binding protein Rheb.	0.670
APZ42_001659	APZ42_034436	A0A164IUD0	A0A164K7C0	Tyrosine-protein kinase receptor.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.553