(135 nodes) Cognition network (Daphnia magna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APZ42_015091	E3 ubiquitin-protein ligase NEURL1B. (628 aa)
	APZ42_016264	Uncharacterized protein. (267 aa)
	APZ42_016272	Putative Dynamin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (523 aa)
	APZ42_016447	Insulin receptor substrate 1-like protein. (1672 aa)
	APZ42_016378	Peptidase S1 domain-containing protein. (217 aa)
	APZ42_016348	Uncharacterized protein; Belongs to the peptidase S1 family. (1511 aa)
	APZ42_016944	Renin receptor. (308 aa)
	APZ42_017726	Neurexin-2-alpha. (1470 aa)
	APZ42_017788	Syntaxin-binding 5-like protein. (276 aa)
	APZ42_017996	Secretory carrier-associated membrane protein. (323 aa)
	APZ42_018131	Non-specific serine/threonine protein kinase. (649 aa)
	APZ42_018100	Uncharacterized protein. (1237 aa)
	APZ42_018088	E3 ubiquitin-protein ligase MYCBP2. (4586 aa)
	APZ42_019522	Dual oxidase maturation factor 2. (603 aa)
	APZ42_019532	Biogenesis of lysosome-related organelles complex 1 subunit 1. (123 aa)
	APZ42_019523	Polyglutamine-binding protein 1. (277 aa)
	APZ42_019443	Enhancer of sevenless 2B protein. (211 aa)
	APZ42_019408	Putative CREB-regulated transcription coactivator 1. (711 aa)
	APZ42_019405	Histone-lysine N-methyltransferase EHMT1. (1097 aa)
	APZ42_020163	Synapse-associated protein 1. (400 aa)
	APZ42_019876	Calcium uniporter protein, mitochondrial. (124 aa)
	APZ42_019870	Lap4,-like protein. (836 aa)
	APZ42_019744	Putative Mitogen-activated protein kinase kinase kinase. (472 aa)
	APZ42_020810	Neurofibromin. (358 aa)
	APZ42_020790	Neurofibromin. (2212 aa)
	APZ42_020568	Tyrosine-protein kinase. (587 aa)
	APZ42_021090	Putative Ubiquitin-protein ligase E3A. (1419 aa)
	APZ42_020988	Putative Cat eye Syndrome critical region protein. (1613 aa)
	APZ42_021493	Rap1 GTPase-activating protein. (168 aa)
	APZ42_022148	Putative Serine/threonine-protein kinase minibrain. (694 aa)
	APZ42_022112	Phorbol-ester/DAG-type domain-containing protein. (159 aa)
	APZ42_022874	DBH monooxygenase 1-like protein. (636 aa)
	APZ42_022792	Glutamate decarboxylase. (513 aa)
	APZ42_022686	Dynamin. (531 aa)
	APZ42_022480	BHLH domain-containing protein. (132 aa)
	APZ42_022299	G-protein-coupled receptor No9; Belongs to the G-protein coupled receptor 1 family. (629 aa)
	APZ42_023127	Mitogen-activated protein kinase. (401 aa)
	APZ42_023318	Uncharacterized protein. (414 aa)
	APZ42_023327	Potassium voltage-gated channel protein Shaker; Belongs to the potassium channel family. (479 aa)
	APZ42_023336	Recombining binding protein suppressor of hairless. (577 aa)
	APZ42_023431	Putative Potassium voltage-gated channel protein eag. (133 aa)
	APZ42_024163	RNA binding protein fox-1 2. (229 aa)
	APZ42_023864	Nipped-B protein. (2128 aa)
	APZ42_024354	Putative ELKS/RAB6-interacting/CAST family member. (667 aa)
	APZ42_024648	Putative Centaurin-gamma-1A. (224 aa)
	APZ42_024747	Fragile X mental retardation Syndrome-related protein. (637 aa)
	APZ42_025310	Uncharacterized protein. (661 aa)
	APZ42_026195	Putative Transcriptional repressor p66-beta. (960 aa)
	APZ42_026509	Potassium voltage-gated channel protein Shal. (262 aa)
	APZ42_026680	ATP-dependent RNA Helicase me31b; Belongs to the DEAD box helicase family. (303 aa)
	APZ42_026816	Peripheral plasma membrane protein CASK. (318 aa)
	APZ42_027223	Putative Synaptic vesicular amine transporter. (158 aa)
	APZ42_027601	Potassium voltage-gated channel protein Shal; Belongs to the potassium channel family. (131 aa)
	APZ42_028367	HECT domain-containing protein. (329 aa)
	APZ42_028573	Trafficking protein particle complex subunit 11. (1111 aa)
	APZ42_029283	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (366 aa)
	APZ42_030650	Fascilin 2-like protein. (771 aa)
	APZ42_030566	NMDA receptor 2; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1298 aa)
	APZ42_030520	Syntaxin-binding 5-like protein. (1349 aa)
	APZ42_030705	Calcium/calmodulin-dependent protein kinase type II alpha chain. (507 aa)
	APZ42_031073	Putative Double-stranded RNA-binding protein Staufen. (542 aa)
	APZ42_031389	Peptidylglycine alpha-hydroxylating monooxygenase. (351 aa)
	APZ42_031488	Extra bases protein. (418 aa)
	APZ42_031779	Tsukushin. (631 aa)
	APZ42_032195	Pro-neuregulin-2, membrane-bound-like protein. (466 aa)
	APZ42_032159	PBPe domain-containing protein. (509 aa)
	APZ42_032338	Uncharacterized protein. (1812 aa)
	APZ42_032889	Putative Tryptophan. (299 aa)
	APZ42_032456	Casein kinase I. (625 aa)
	APZ42_000788	Putative Recombining binding protein suppressor of hairless. (118 aa)
	APZ42_001722	Putative Presenilin. (124 aa)
	APZ42_002051	Neurexin-2-alpha. (256 aa)
	APZ42_002704	Recombining binding protein suppressor of hairless. (127 aa)
	APZ42_002734	Pro-neuregulin-2, membrane-bound. (63 aa)
	APZ42_002843	Putative 6-phosphofructokinase. (102 aa)
	APZ42_003890	ATP-dependent RNA Helicase me31b. (92 aa)
	APZ42_004136	Putative S-(Hydroxymethyl)glutathione dehydrogenase. (97 aa)
	APZ42_005047	ATP-dependent RNA Helicase me31b. (121 aa)
	APZ42_005050	Putative ATP-dependent RNA Helicase me31b. (158 aa)
	APZ42_011072	Putative Centaurin-gamma-1A. (947 aa)
	APZ42_011469	Putative Potassium voltage-gated channel protein eag. (956 aa)
	APZ42_012837	Protein argonaute-1. (925 aa)
	APZ42_013663	Glucosylceramidase. (516 aa)
	APZ42_013595	Putative ELKS/Rab6-interacting/CAST family member 1. (1720 aa)
	APZ42_014156	Uncharacterized protein. (2453 aa)
	APZ42_014122	Uncharacterized protein. (810 aa)
	APZ42_015385	Synapsin. (568 aa)
	APZ42_015380	tRNA (Cytosine(34)-C(5))-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (523 aa)
	APZ42_015266	RNA-binding protein orb2. (193 aa)
	APZ42_015225	Putative E3 ubiquitin-protein ligase RNF181. (823 aa)
	APZ42_015190	Putative Huntingtin. (2896 aa)
	APZ42_014948	Putative Pumilio. (1214 aa)
	APZ42_016148	Uncharacterized protein. (428 aa)
	APZ42_023820	Lap4 protein. (1949 aa)
	APZ42_023800	Putative Forkhead box protein P4. (939 aa)
	APZ42_032336	Ankyrin repeat and SOCS box protein 3. (2634 aa)
	APZ42_032905	Tryptophan 5-hydroxylase 2. (445 aa)
	APZ42_028369	HECT domain-containing protein. (455 aa)
	APZ42_019902	Rap1 GTPase-activating protein. (1177 aa)
	APZ42_018682	C2 domain-containing protein. (244 aa)
	APZ42_019919	Putative Dual oxidase maturation factor 2. (570 aa)
	APZ42_020558	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (416 aa)
	APZ42_001903	Protein BTG4. (207 aa)
	APZ42_028089	Glutamate--cysteine ligase regulatory subunit. (236 aa)
	APZ42_020415	WW domain-containing adapter protein with coiled-coil. (608 aa)
	APZ42_033818	Dihydropyrimidinase-related protein 5. (611 aa)
	APZ42_025063	14-3-3 protein zeta/delta; Belongs to the 14-3-3 family. (247 aa)
	EOG090X0FJX	Calcipressin-3. (244 aa)
	APZ42_028736	Alcohol dehydrogenase class. (378 aa)
	APZ42_017554	Glycolipid-transport protein. (180 aa)
	APZ42_015097	Glucose-dependent insulinotropic receptor; Belongs to the G-protein coupled receptor 1 family. (589 aa)
	APZ42_016061	Beta-1,4-mannosyl-glycoprotein. (494 aa)
	APZ42_025681	Tyrosine-protein kinase. (712 aa)
	APZ42_027286	Lipopolysaccharide-responsive and beige anchor protein. (2856 aa)
	APZ42_027371	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (624 aa)
	APZ42_027637	Glucosylceramidase. (519 aa)
	APZ42_012906	ATP-dependent RNA Helicase me31b; Belongs to the DEAD box helicase family. (450 aa)
	APZ42_015890	Origin recognition complex subunit 3. (707 aa)
	APZ42_029057	Exportin-6. (1125 aa)
	APZ42_018322	Serum response factor-like protein. (389 aa)
	APZ42_014945	Beta-amyloid-like protein. (744 aa)
	APZ42_030839	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (377 aa)
	APZ42_034125	A-kinase anchor protein 1, mitochondrial. (496 aa)
	APZ42_022105	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (770 aa)
	APZ42_012137	Glutamate receptor ionotropic, NMDA. (989 aa)
	APZ42_027415	Protein argonaute-1; Belongs to the argonaute family. (945 aa)
	APZ42_013662	Glucosylceramidase. (538 aa)
	APZ42_020282	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1140 aa)
	APZ42_017992	Secretory carrier-associated membrane protein. (346 aa)
	APZ42_025753	Low-density lipoprotein receptor-related protein 6. (1758 aa)
	APZ42_022004	Putative Tyrosine-protein kinase Btk29A. (1513 aa)
	APZ42_017933	Cytokine-inducible SH2-containing protein. (465 aa)
	APZ42_025157	Choline/ethanolamine kinase. (352 aa)
	APZ42_017495	Dopamine/Ecdysteroid receptor. (387 aa)
	APZ42_019740	Putative Mitogen-activated protein kinase kinase kinase. (961 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_000788	APZ42_017788	A0A164JDM5	A0A164ZKM6	Putative Recombining binding protein suppressor of hairless.	Syntaxin-binding 5-like protein.	0.468
APZ42_000788	APZ42_020282	A0A164JDM5	A0A0P5BZJ2	Putative Recombining binding protein suppressor of hairless.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.612
APZ42_000788	APZ42_020988	A0A164JDM5	A0A164WVX5	Putative Recombining binding protein suppressor of hairless.	Putative Cat eye Syndrome critical region protein.	0.692
APZ42_000788	APZ42_030520	A0A164JDM5	A0A164NK76	Putative Recombining binding protein suppressor of hairless.	Syntaxin-binding 5-like protein.	0.468
APZ42_001722	APZ42_014945	A0A164ISJ8	A0A0P5RBU0	Putative Presenilin.	Beta-amyloid-like protein.	0.722
APZ42_001722	APZ42_016447	A0A164ISJ8	A0A165AFH6	Putative Presenilin.	Insulin receptor substrate 1-like protein.	0.447
APZ42_001722	APZ42_020558	A0A164ISJ8	A0A162CBY6	Putative Presenilin.	Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.539
APZ42_001722	APZ42_020568	A0A164ISJ8	A0A164X7E9	Putative Presenilin.	Tyrosine-protein kinase.	0.539
APZ42_001722	APZ42_022004	A0A164ISJ8	A0A0P4WMC5	Putative Presenilin.	Putative Tyrosine-protein kinase Btk29A.	0.522
APZ42_001722	APZ42_025681	A0A164ISJ8	A0A0P5XZT7	Putative Presenilin.	Tyrosine-protein kinase.	0.522
APZ42_001722	APZ42_027371	A0A164ISJ8	A0A0P5WIM4	Putative Presenilin.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.522
APZ42_002051	APZ42_017726	A0A164IJN5	A0A164ZLW9	Neurexin-2-alpha.	Neurexin-2-alpha.	0.899
APZ42_002051	APZ42_026816	A0A164IJN5	A0A164RYF7	Neurexin-2-alpha.	Peripheral plasma membrane protein CASK.	0.991
APZ42_002051	APZ42_030705	A0A164IJN5	A0A164NIK1	Neurexin-2-alpha.	Calcium/calmodulin-dependent protein kinase type II alpha chain.	0.668
APZ42_002704	APZ42_017788	A0A164I3H5	A0A164ZKM6	Recombining binding protein suppressor of hairless.	Syntaxin-binding 5-like protein.	0.468
APZ42_002704	APZ42_020282	A0A164I3H5	A0A0P5BZJ2	Recombining binding protein suppressor of hairless.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.612
APZ42_002704	APZ42_020988	A0A164I3H5	A0A164WVX5	Recombining binding protein suppressor of hairless.	Putative Cat eye Syndrome critical region protein.	0.692
APZ42_002704	APZ42_023336	A0A164I3H5	A0A164V1E8	Recombining binding protein suppressor of hairless.	Recombining binding protein suppressor of hairless.	0.942
APZ42_002704	APZ42_030520	A0A164I3H5	A0A164NK76	Recombining binding protein suppressor of hairless.	Syntaxin-binding 5-like protein.	0.468
APZ42_002734	APZ42_019443	A0A164I2R4	A0A164Y7E8	Pro-neuregulin-2, membrane-bound.	Enhancer of sevenless 2B protein.	0.627