(34 nodes) Iron ion homeostasis network (Daphnia magna)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	APZ42_018619	Eukaryotic translation initiation factor 2-alpha kinase 1. (636 aa)
	APZ42_016483	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. (170 aa)
	APZ42_011580	Uncharacterized protein. (546 aa)
	APZ42_024540	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. (169 aa)
	APZ42_024579	F-box/LRR-repeat protein. (571 aa)
	APZ42_022342	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. (230 aa)
	APZ42_034484	Malvolio protein. (471 aa)
	APZ42_002911	BolA 1-like protein; Belongs to the BolA/IbaG family. (114 aa)
	APZ42_015817	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (257 aa)
	APZ42_005869	Cytoplasmic aconitate hydratase. (163 aa)
	APZ42_001715	ATP-binding cassette sub-family B member. (129 aa)
	APZ42_000589	Malvolio protein. (199 aa)
	APZ42_034482	Iron-sulfur cluster assembly enzyme ISCU; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (164 aa)
	APZ42_031636	Laccase-1; Belongs to the multicopper oxidase family. (585 aa)
	APZ42_029718	Natural resistance-associated macrophage protein 2. (592 aa)
	APZ42_029148	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. (170 aa)
	APZ42_029162	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. (170 aa)
	APZ42_029165	Ferritin-like protein. (423 aa)
	APZ42_023753	Mitoferrin-1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (373 aa)
	APZ42_023628	Cytochrome b ascorbate-dependent protein 3. (268 aa)
	APZ42_022333	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. (223 aa)
	APZ42_019237	Laccase 2; Belongs to the multicopper oxidase family. (717 aa)
	APZ42_016498	Solute carrier family 40 member 1. (789 aa)
	APZ42_014628	ATP-binding cassette sub-family B member 7, mitochondrial. (700 aa)
	APZ42_018799	F-box/LRR-repeat protein. (631 aa)
	APZ42_025174	Iron-responsive element binding protein 2 variant. (1065 aa)
	APZ42_023321	1,4-alpha-glucan-branching enzyme. (704 aa)
	APZ42_019644	Glutaredoxin-3. (349 aa)
	APZ42_027331	1,4-alpha-glucan-branching enzyme. (694 aa)
	APZ42_030373	Frataxin, mitochondrial. (188 aa)
	APZ42_019234	Multicopper oxidase; Belongs to the multicopper oxidase family. (741 aa)
	APZ42_022329	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family. (207 aa)
	APZ42_019498	BolA 1-like protein; Belongs to the BolA/IbaG family. (136 aa)
	APZ42_023586	Zinc transporter ZIP13. (497 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_001715	APZ42_019644	A0A164IST5	A0A0P5E9S7	ATP-binding cassette sub-family B member.	Glutaredoxin-3.	0.418
APZ42_001715	APZ42_023753	A0A164IST5	A0A164U4L4	ATP-binding cassette sub-family B member.	Mitoferrin-1; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.477
APZ42_001715	APZ42_030373	A0A164IST5	A0A0P5HGI1	ATP-binding cassette sub-family B member.	Frataxin, mitochondrial.	0.489
APZ42_001715	APZ42_034482	A0A164IST5	A0A164K803	ATP-binding cassette sub-family B member.	Iron-sulfur cluster assembly enzyme ISCU; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.485
APZ42_002911	APZ42_019644	A0A162CXS7	A0A0P5E9S7	BolA 1-like protein; Belongs to the BolA/IbaG family.	Glutaredoxin-3.	0.967
APZ42_002911	APZ42_030373	A0A162CXS7	A0A0P5HGI1	BolA 1-like protein; Belongs to the BolA/IbaG family.	Frataxin, mitochondrial.	0.412
APZ42_002911	APZ42_034482	A0A162CXS7	A0A164K803	BolA 1-like protein; Belongs to the BolA/IbaG family.	Iron-sulfur cluster assembly enzyme ISCU; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.489
APZ42_005869	APZ42_019644	A0A164G7L3	A0A0P5E9S7	Cytoplasmic aconitate hydratase.	Glutaredoxin-3.	0.499
APZ42_005869	APZ42_023753	A0A164G7L3	A0A164U4L4	Cytoplasmic aconitate hydratase.	Mitoferrin-1; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.400
APZ42_005869	APZ42_024579	A0A164G7L3	A0A0P6GT10	Cytoplasmic aconitate hydratase.	F-box/LRR-repeat protein.	0.957
APZ42_005869	APZ42_030373	A0A164G7L3	A0A0P5HGI1	Cytoplasmic aconitate hydratase.	Frataxin, mitochondrial.	0.535
APZ42_005869	APZ42_034482	A0A164G7L3	A0A164K803	Cytoplasmic aconitate hydratase.	Iron-sulfur cluster assembly enzyme ISCU; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.422
APZ42_011580	APZ42_016483	A0A0P5YUC3	A0A0P5XQQ1	Uncharacterized protein.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	0.772
APZ42_011580	APZ42_022329	A0A0P5YUC3	A0A0P5T847	Uncharacterized protein.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	0.772
APZ42_011580	APZ42_022333	A0A0P5YUC3	A0A164VFG7	Uncharacterized protein.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	0.701
APZ42_011580	APZ42_022342	A0A0P5YUC3	A0A162C6Y3	Uncharacterized protein.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	0.701
APZ42_011580	APZ42_024540	A0A0P5YUC3	A0A0P6D1M1	Uncharacterized protein.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	0.772
APZ42_011580	APZ42_029148	A0A0P5YUC3	A0A164PW42	Uncharacterized protein.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	0.772
APZ42_011580	APZ42_029162	A0A0P5YUC3	A0A164PW54	Uncharacterized protein.	Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Belongs to the ferritin family.	0.772
APZ42_011580	APZ42_029165	A0A0P5YUC3	A0A164PW75	Uncharacterized protein.	Ferritin-like protein.	0.701