(88 nodes) Regulation of stress-activated protein kinase signaling cascade network (Daphnia magna)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APZ42_002212	Serine/threonine-protein phosphatase 6 regulatory subunit 3. (206 aa)
	APZ42_018598	LIM domain-containing protein. (342 aa)
	EOG090X02BW	Engulfment and cell motility protein 3. (736 aa)
	APZ42_012616	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
	APZ42_034380	F-box/WD repeat-containing protein TBL1XR1. (492 aa)
	APZ42_026226	PRA1 family protein. (189 aa)
	APZ42_015851	Wd-repeat protein. (392 aa)
	APZ42_031265	Ras suppressor protein 1. (271 aa)
	APZ42_019982	Btb/poz domain-containing protein. (322 aa)
	APZ42_016364	Eukaryotic translation initiation factor 2-alpha kinase 3-like protein. (535 aa)
	APZ42_022107	Putative SH3 domain-containing RING finger protein 3. (805 aa)
	APZ42_031956	F-box/WD repeat-containing TBL1XR1-like protein. (735 aa)
	APZ42_032372	Receptor protein-tyrosine kinase. (1457 aa)
	APZ42_030312	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (758 aa)
	APZ42_019921	Protein kinase domain-containing protein. (749 aa)
	APZ42_020162	Putative Dual specificity protein phosphatase 10. (1162 aa)
	APZ42_020795	Battenin. (426 aa)
	APZ42_019958	Uncharacterized protein. (933 aa)
	APZ42_005717	BTB domain-containing protein. (141 aa)
	APZ42_029018	BTB domain-containing protein. (294 aa)
	APZ42_028195	Putative Transcriptional regulator ATRX. (2000 aa)
	APZ42_028233	E3 ubiquitin-protein ligase HUWE1. (4363 aa)
	APZ42_028096	Uncharacterized protein. (550 aa)
	APZ42_031764	Protein kinase at 92B. (1374 aa)
	APZ42_024651	Putative Tyrosine-protein phosphatase non-receptor type 1. (512 aa)
	APZ42_015896	WD repeat-containing protein 53. (396 aa)
	APZ42_016062	Putative wd-repeat protein. (376 aa)
	APZ42_016059	Hindsight transcription factor-like protein. (1512 aa)
	APZ42_014768	Dual specificity protein phosphatase 10. (552 aa)
	APZ42_014173	Uncharacterized protein. (563 aa)
	EOG090X0I8J	Ubiquitin-conjugating enzyme E2 variant 2. (147 aa)
	APZ42_012654	Alphabet. (362 aa)
	APZ42_011884	ALG-2 interacting protein X. (813 aa)
	APZ42_008239	Programmed cell death 6-interacting protein. (363 aa)
	APZ42_004793	Uncharacterized protein. (299 aa)
	APZ42_001837	Serine/threonine-protein phosphatase 6 regulatory subunit 3. (437 aa)
	APZ42_001129	SNF2_N domain-containing protein. (110 aa)
	APZ42_000652	Uncharacterized protein. (215 aa)
	APZ42_000618	Uncharacterized protein. (147 aa)
	APZ42_000361	Helicase C-terminal domain-containing protein. (88 aa)
	APZ42_033777	TNF receptor-associated factor 4. (359 aa)
	APZ42_031428	Programmed cell death protein 6. (184 aa)
	APZ42_030507	Pre-mRNA-splicing factor ATP-dependent RNA Helicase DHX15. (734 aa)
	APZ42_030510	Mekk1. (1578 aa)
	APZ42_029542	Mast/stem cell growth factor receptor Kit. (903 aa)
	APZ42_028603	N-acetyltransferase 9 protein. (178 aa)
	APZ42_028700	Mitogen-activated protein kinase kinase kinase kinase. (382 aa)
	APZ42_028093	Uncharacterized protein. (619 aa)
	APZ42_027909	EF-hand domain-containing protein. (527 aa)
	APZ42_027346	Uncharacterized protein. (602 aa)
	APZ42_027381	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (276 aa)
	APZ42_026972	C-Jun-amino-terminal kinase-interacting protein 3. (1396 aa)
	APZ42_025854	Uncharacterized protein. (884 aa)
	APZ42_025597	Eukaryotic translation initiation factor 2-alpha kinase. (1127 aa)
	APZ42_024810	BTB domain-containing protein. (399 aa)
	APZ42_024409	Roadkill protein. (340 aa)
	APZ42_023975	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (409 aa)
	APZ42_024062	Cylindromatosis. (777 aa)
	APZ42_024303	Putative Inactive tyrosine-protein kinase 7. (1141 aa)
	APZ42_023578	Dedicator of cytokinesis protein 5; Belongs to the DOCK family. (2046 aa)
	APZ42_023447	MAP kinase-activated protein kinase; Belongs to the protein kinase superfamily. (332 aa)
	APZ42_023448	Skb11-like protein. (416 aa)
	APZ42_023262	Putative Transcriptional regulator ATRX. (1778 aa)
	APZ42_021685	Tyrosine-protein kinase JAK1. (1217 aa)
	APZ42_021254	TNF receptor-associated factor 4. (118 aa)
	APZ42_019862	Phosphatidylinositide phosphatase SAC1. (317 aa)
	APZ42_020054	Putative Vascular endothelial growth factor receptor 3. (1011 aa)
	APZ42_020123	Protein kinase domain-containing protein. (468 aa)
	APZ42_020116	Putative Receptor-type tyrosine-protein kinase FLT3. (791 aa)
	APZ42_020161	Putative Vascular endothelial growth factor receptor 1. (994 aa)
	APZ42_020156	Protein kinase domain-containing protein. (1515 aa)
	APZ42_020225	Receptor protein-tyrosine kinase. (1213 aa)
	APZ42_018040	Serine/threonine-protein phosphatase. (304 aa)
	APZ42_017130	Uncharacterized protein. (1857 aa)
	APZ42_016548	Protein kinase domain-containing protein. (927 aa)
	APZ42_003663	Uncharacterized protein. (76 aa)
	APZ42_031694	Ubiquitin carboxyl-terminal hydrolase. (819 aa)
	APZ42_013207	Menin. (677 aa)
	APZ42_026892	Striatin-interacting protein. (805 aa)
	APZ42_017341	Dual specificity protein phosphatase 12. (288 aa)
	APZ42_025525	Putative Class c scavenger receptor sushi/scr/ccp. (145 aa)
	APZ42_020174	Putative Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase. (633 aa)
	APZ42_014202	BTB domain-containing protein. (254 aa)
	APZ42_019327	Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6. (401 aa)
	APZ42_017278	Uncharacterized protein. (582 aa)
	APZ42_018957	F-box/WD repeat-containing TBL1XR1-like protein. (373 aa)
	APZ42_012106	C-Jun-amino-terminal kinase-interacting protein. (430 aa)
	APZ42_015145	Striatin-3. (780 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_000361	EOG090X0I8J	A0A164JQH2	A0A162QZU0	Helicase C-terminal domain-containing protein.	Ubiquitin-conjugating enzyme E2 variant 2.	0.554
APZ42_000618	EOG090X0I8J	A0A164JI05	A0A162QZU0	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2 variant 2.	0.554
APZ42_001129	EOG090X0I8J	A0A164J5Q5	A0A162QZU0	SNF2_N domain-containing protein.	Ubiquitin-conjugating enzyme E2 variant 2.	0.554
APZ42_001837	APZ42_018040	A0A164IPW0	A0A164ZI70	Serine/threonine-protein phosphatase 6 regulatory subunit 3.	Serine/threonine-protein phosphatase.	0.965
APZ42_002212	APZ42_018040	A0A162C5Q5	A0A164ZI70	Serine/threonine-protein phosphatase 6 regulatory subunit 3.	Serine/threonine-protein phosphatase.	0.965
APZ42_003663	APZ42_014768	A0A168EL79	A0A162PKT5	Uncharacterized protein.	Dual specificity protein phosphatase 10.	0.443
APZ42_003663	APZ42_017341	A0A168EL79	A0A0N8CZI5	Uncharacterized protein.	Dual specificity protein phosphatase 12.	0.443
APZ42_003663	APZ42_018040	A0A168EL79	A0A164ZI70	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.560
APZ42_003663	APZ42_020162	A0A168EL79	A0A162CEE5	Uncharacterized protein.	Putative Dual specificity protein phosphatase 10.	0.443
APZ42_004793	APZ42_012106	A0A164GUB4	A0A0P5D8G0	Uncharacterized protein.	C-Jun-amino-terminal kinase-interacting protein.	0.721
APZ42_004793	APZ42_012654	A0A164GUB4	A0A162RKC5	Uncharacterized protein.	Alphabet.	0.775
APZ42_004793	APZ42_016364	A0A164GUB4	A0A0P5XFU1	Uncharacterized protein.	Eukaryotic translation initiation factor 2-alpha kinase 3-like protein.	0.520
APZ42_004793	APZ42_016548	A0A164GUB4	A0A165AHT4	Uncharacterized protein.	Protein kinase domain-containing protein.	0.900
APZ42_004793	APZ42_020174	A0A164GUB4	A0A0N8DB68	Uncharacterized protein.	Putative Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase.	0.520
APZ42_004793	APZ42_021254	A0A164GUB4	A0A164WU47	Uncharacterized protein.	TNF receptor-associated factor 4.	0.622
APZ42_004793	APZ42_022107	A0A164GUB4	A0A0P5YEQ6	Uncharacterized protein.	Putative SH3 domain-containing RING finger protein 3.	0.539
APZ42_004793	APZ42_023447	A0A164GUB4	A0A164UWH4	Uncharacterized protein.	MAP kinase-activated protein kinase; Belongs to the protein kinase superfamily.	0.448
APZ42_004793	APZ42_023448	A0A164GUB4	A0A164UXK8	Uncharacterized protein.	Skb11-like protein.	0.586
APZ42_004793	APZ42_023975	A0A164GUB4	A0A164UB81	Uncharacterized protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.681
APZ42_004793	APZ42_024062	A0A164GUB4	A0A164UG01	Uncharacterized protein.	Cylindromatosis.	0.753