(42 nodes) Apoptotic signaling pathway network (Daphnia magna)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APZ42_007877	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (252 aa)
	APZ42_018917	Serine/threonine-protein kinase hippo. (576 aa)
	APZ42_008228	Calcium/calmodulin-dependent protein kinase kinase; Belongs to the protein kinase superfamily. (308 aa)
	APZ42_019518	BCL2/adenovirus E1B 19 kDa protein-interacting protein. (203 aa)
	APZ42_028195	Putative Transcriptional regulator ATRX. (2000 aa)
	APZ42_026239	Caspase Dronc; Belongs to the peptidase C14A family. (466 aa)
	APZ42_008075	Protein kinase domain-containing protein. (282 aa)
	APZ42_015744	Ovarian-specific serine/threonine-protein kinase Lok; Belongs to the protein kinase superfamily. (429 aa)
	APZ42_015048	Putative Serine/threonine-protein kinase/endoribonuclease IRE2. (406 aa)
	APZ42_014663	Retinoblastoma family protein. (1077 aa)
	APZ42_013620	DNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family. (3687 aa)
	APZ42_012379	Apoptotic Protease-activating factor 1. (1391 aa)
	APZ42_016799	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (639 aa)
	APZ42_016794	Influenza virus NS1A-binding protein. (775 aa)
	APZ42_016661	DNA excision repair ERCC-6-like protein. (1184 aa)
	APZ42_020063	Mismatch repair ATPase Msh2. (200 aa)
	EOG090X0B66	Transcription factor. (447 aa)
	APZ42_020911	Death-associated protein 1. (106 aa)
	APZ42_020937	Apoptosis regulatory protein Siva. (177 aa)
	APZ42_022818	UPF0671 protein. (71 aa)
	APZ42_022951	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (207 aa)
	APZ42_023262	Putative Transcriptional regulator ATRX. (1778 aa)
	APZ42_026440	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (276 aa)
	APZ42_029513	Serine/threonine-protein kinase/endoribonuclease IRE2. (479 aa)
	APZ42_030443	Putative Nibrin. (610 aa)
	APZ42_030510	Mekk1. (1578 aa)
	APZ42_032067	Uncharacterized protein. (1028 aa)
	APZ42_000361	Helicase C-terminal domain-containing protein. (88 aa)
	APZ42_000618	Uncharacterized protein. (147 aa)
	APZ42_001129	SNF2_N domain-containing protein. (110 aa)
	APZ42_006353	Protein kinase domain-containing protein. (398 aa)
	APZ42_007746	Protein kinase domain-containing protein. (225 aa)
	APZ42_011247	Serine/threonine-protein kinase/endoribonuclease IRE2. (1597 aa)
	APZ42_020472	Apoptosis regulator BAX. (210 aa)
	APZ42_022277	Non-specific serine/threonine protein kinase. (2957 aa)
	APZ42_023822	Serine/threonine-protein kinase LATS1. (1138 aa)
	APZ42_024973	Cyclin dependent kinase 5 activator-like protein. (366 aa)
	APZ42_018637	Apoptosis regulator R1. (193 aa)
	APZ42_016098	Kinase c delta type. (287 aa)
	APZ42_026226	PRA1 family protein. (189 aa)
	APZ42_011718	Cellular tumor antigen p53. (413 aa)
	APZ42_029250	Uncharacterized protein. (417 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_000361	APZ42_011718	A0A164JQH2	A0A0P5UBN4	Helicase C-terminal domain-containing protein.	Cellular tumor antigen p53.	0.493
APZ42_000361	APZ42_030443	A0A164JQH2	A0A164NRX7	Helicase C-terminal domain-containing protein.	Putative Nibrin.	0.439
APZ42_000618	APZ42_011718	A0A164JI05	A0A0P5UBN4	Uncharacterized protein.	Cellular tumor antigen p53.	0.493
APZ42_000618	APZ42_030443	A0A164JI05	A0A164NRX7	Uncharacterized protein.	Putative Nibrin.	0.439
APZ42_001129	APZ42_011718	A0A164J5Q5	A0A0P5UBN4	SNF2_N domain-containing protein.	Cellular tumor antigen p53.	0.493
APZ42_001129	APZ42_030443	A0A164J5Q5	A0A164NRX7	SNF2_N domain-containing protein.	Putative Nibrin.	0.439
APZ42_006353	APZ42_011718	A0A164FYA3	A0A0P5UBN4	Protein kinase domain-containing protein.	Cellular tumor antigen p53.	0.541
APZ42_006353	APZ42_012379	A0A164FYA3	A0A162RRZ9	Protein kinase domain-containing protein.	Apoptotic Protease-activating factor 1.	0.477
APZ42_006353	APZ42_013620	A0A164FYA3	A0A162QPJ7	Protein kinase domain-containing protein.	DNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.411
APZ42_006353	APZ42_014663	A0A164FYA3	A0A162PPF2	Protein kinase domain-containing protein.	Retinoblastoma family protein.	0.551
APZ42_006353	APZ42_018637	A0A164FYA3	A0A0P5E6Z1	Protein kinase domain-containing protein.	Apoptosis regulator R1.	0.491
APZ42_006353	APZ42_018917	A0A164FYA3	A0A0P6EU47	Protein kinase domain-containing protein.	Serine/threonine-protein kinase hippo.	0.611
APZ42_006353	APZ42_020472	A0A164FYA3	A0A0P4XHJ8	Protein kinase domain-containing protein.	Apoptosis regulator BAX.	0.520
APZ42_006353	APZ42_022951	A0A164FYA3	A0A164VB60	Protein kinase domain-containing protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.505
APZ42_007746	APZ42_011718	A0A164F446	A0A0P5UBN4	Protein kinase domain-containing protein.	Cellular tumor antigen p53.	0.541
APZ42_007746	APZ42_012379	A0A164F446	A0A162RRZ9	Protein kinase domain-containing protein.	Apoptotic Protease-activating factor 1.	0.477
APZ42_007746	APZ42_013620	A0A164F446	A0A162QPJ7	Protein kinase domain-containing protein.	DNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.411
APZ42_007746	APZ42_014663	A0A164F446	A0A162PPF2	Protein kinase domain-containing protein.	Retinoblastoma family protein.	0.551
APZ42_007746	APZ42_018637	A0A164F446	A0A0P5E6Z1	Protein kinase domain-containing protein.	Apoptosis regulator R1.	0.491
APZ42_007746	APZ42_018917	A0A164F446	A0A0P6EU47	Protein kinase domain-containing protein.	Serine/threonine-protein kinase hippo.	0.598