(51 nodes) C2 domain network (Daphnia magna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APZ42_022061	Synaptotagmin-11. (517 aa)
	APZ42_024257	Copine-5 copine v. (519 aa)
	APZ42_022105	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (770 aa)
	APZ42_032867	C2 domain-containing protein 5. (1021 aa)
	APZ42_011760	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide. (952 aa)
	APZ42_017917	Epidermal growth factor receptor substrate 15 1-like protein. (1834 aa)
	APZ42_026048	Putative Active breakpoint cluster region-related protein. (1145 aa)
	APZ42_011645	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1220 aa)
	APZ42_023917	Copine-7. (527 aa)
	APZ42_015040	Phosphoinositide phospholipase C. (1294 aa)
	APZ42_027334	E3 ubiquitin-protein ligase. (836 aa)
	APZ42_018682	C2 domain-containing protein. (244 aa)
	APZ42_032784	Putative Synaptotagmin beta. (897 aa)
	APZ42_023911	Uncharacterized protein. (524 aa)
	APZ42_025664	Protein piccolo. (350 aa)
	APZ42_016104	Copine-7. (559 aa)
	APZ42_016151	E3 ubiquitin-protein ligase SMURF2. (690 aa)
	APZ42_015254	Protein WWC3. (1296 aa)
	APZ42_014572	Synaptotagmin 2 variant 2-like protein. (123 aa)
	APZ42_014597	Putative Ras GTPase-activating protein nGAP. (1410 aa)
	APZ42_014633	Phosphoinositide phospholipase C. (610 aa)
	APZ42_013700	Synaptotagmin-17. (549 aa)
	APZ42_012862	Synaptotagmin-12/sw-like protein. (518 aa)
	APZ42_012853	Putative Synaptotagmin 7. (659 aa)
	APZ42_012387	Phosphoinositide phospholipase C. (805 aa)
	APZ42_011276	Putative Regulator of G-protein signaling 17. (2818 aa)
	APZ42_011307	Synaptotagmin-15. (464 aa)
	APZ42_004587	Putative Coiled-coil and C2 domain-containing protein 1. (135 aa)
	APZ42_034501	Coiled-coil and C2 domain-containing 1-like protein. (606 aa)
	APZ42_033470	Serine/threonine-protein kinase D3. (795 aa)
	APZ42_032515	Synaptotagmin 1 protein, variant 2. (445 aa)
	APZ42_032544	Uncharacterized protein. (3708 aa)
	APZ42_032734	Rab11 family-interacting protein. (1044 aa)
	APZ42_030382	Rho GTPase-activating protein 28. (1734 aa)
	APZ42_029896	Protein unc-13 D. (1262 aa)
	APZ42_029338	Phosphoinositide phospholipase C. (2451 aa)
	APZ42_028167	Regulating synaptic membrane exocytosis 2-like protein. (1032 aa)
	APZ42_028074	Calcium-dependent secretion activator 1. (1367 aa)
	APZ42_026664	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta; Belongs to the PI3/PI4-kinase family. (1689 aa)
	APZ42_025712	Putative BAI1-associated protein 3. (712 aa)
	APZ42_024807	Phosphoinositide phospholipase C. (1001 aa)
	APZ42_023797	Phosphoinositide phospholipase C. (856 aa)
	APZ42_023950	E3 ubiquitin-protein ligase. (872 aa)
	APZ42_024065	Coiled-coil and C2 domain-containing protein 2A. (1310 aa)
	APZ42_022103	Phosphoinositide phospholipase C. (590 aa)
	APZ42_022183	Protein unc-13 A. (3026 aa)
	APZ42_021610	Protein kinase C; Belongs to the protein kinase superfamily. (486 aa)
	APZ42_021214	Putative Multiple C2 and transmembrane domain-containing protein 1. (988 aa)
	APZ42_019860	Toll-interacting protein. (325 aa)
	APZ42_019901	Synaptotagmin 2 variant 2-like protein. (911 aa)
	APZ42_016635	Putative Synaptotagmin 16. (547 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_011276	APZ42_011645	A0A162SJR5	A0A0P5TMV7	Putative Regulator of G-protein signaling 17.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.632
APZ42_011276	APZ42_021610	A0A162SJR5	A0A164WIQ8	Putative Regulator of G-protein signaling 17.	Protein kinase C; Belongs to the protein kinase superfamily.	0.592
APZ42_011307	APZ42_017917	A0A162SKG5	A0A0P5T7E4	Synaptotagmin-15.	Epidermal growth factor receptor substrate 15 1-like protein.	0.682
APZ42_011307	APZ42_021214	A0A162SKG5	A0A164WV46	Synaptotagmin-15.	Putative Multiple C2 and transmembrane domain-containing protein 1.	0.468
APZ42_011307	APZ42_022183	A0A162SKG5	A0A164W4P6	Synaptotagmin-15.	Protein unc-13 A.	0.491
APZ42_011307	APZ42_028167	A0A162SKG5	A0A164QJQ3	Synaptotagmin-15.	Regulating synaptic membrane exocytosis 2-like protein.	0.661
APZ42_011645	APZ42_011276	A0A0P5TMV7	A0A162SJR5	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Putative Regulator of G-protein signaling 17.	0.632
APZ42_011645	APZ42_012387	A0A0P5TMV7	A0A162RSN4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Phosphoinositide phospholipase C.	0.658
APZ42_011645	APZ42_014633	A0A0P5TMV7	A0A162PSA0	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Phosphoinositide phospholipase C.	0.673
APZ42_011645	APZ42_015040	A0A0P5TMV7	A0A0P5Y732	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Phosphoinositide phospholipase C.	0.918
APZ42_011645	APZ42_021610	A0A0P5TMV7	A0A164WIQ8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Protein kinase C; Belongs to the protein kinase superfamily.	0.663
APZ42_011645	APZ42_022103	A0A0P5TMV7	A0A164W1R4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Phosphoinositide phospholipase C.	0.659
APZ42_011645	APZ42_022105	A0A0P5TMV7	A0A0P5F335	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.746
APZ42_011645	APZ42_023797	A0A0P5TMV7	A0A164U5Q6	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Phosphoinositide phospholipase C.	0.664
APZ42_011645	APZ42_024807	A0A0P5TMV7	A0A164TQW3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Phosphoinositide phospholipase C.	0.934
APZ42_011645	APZ42_029338	A0A0P5TMV7	A0A164PHP8	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	Phosphoinositide phospholipase C.	0.770
APZ42_011760	APZ42_014597	A0A0P5KQF9	A0A162PS34	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide.	Putative Ras GTPase-activating protein nGAP.	0.861
APZ42_011760	APZ42_021610	A0A0P5KQF9	A0A164WIQ8	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide.	Protein kinase C; Belongs to the protein kinase superfamily.	0.687
APZ42_011760	APZ42_022105	A0A0P5KQF9	A0A0P5F335	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.670
APZ42_012387	APZ42_011645	A0A162RSN4	A0A0P5TMV7	Phosphoinositide phospholipase C.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.	0.658