(33 nodes) Cobalamin (Cbl, vitamin B12) transport and metabolism network (Daphnia magna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APZ42_021050	Methylmalonic aciduria type A protein, mitochondrial. (385 aa)
	APZ42_026191	Methylmalonyl-CoA mutase, mitochondrial. (745 aa)
	APZ42_024152	Uncharacterized protein. (435 aa)
	APZ42_021391	Aldo-keto reductase family 4 member C9. (289 aa)
	APZ42_019315	Methylmalonic aciduria and homocystinuria type D protein, mitochondrial. (308 aa)
	APZ42_034126	Very Low-density lipoprotein receptor. (887 aa)
	APZ42_016775	Methylmalonic aciduria and homocystinuria type C protein. (242 aa)
	APZ42_031701	Protein amnionless. (692 aa)
	APZ42_028750	Uncharacterized protein. (508 aa)
	APZ42_013795	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1260 aa)
	APZ42_019770	Low-density lipoprotein receptor. (834 aa)
	APZ42_021500	Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (238 aa)
	APZ42_022993	Oxidoreductase ZK1290.5-like protein. (302 aa)
	APZ42_000750	Cubilin. (527 aa)
	APZ42_029176	Putative Cubilin. (72 aa)
	APZ42_030846	MINDY_DUB domain-containing protein. (935 aa)
	APZ42_013388	Putative Basement membrane-specific heparan sulfate proteoglycan core protein. (1513 aa)
	APZ42_012205	Uncharacterized protein. (366 aa)
	APZ42_010850	Putative Vitellogenin receptor. (1351 aa)
	APZ42_002157	METMALONYL_COA_MUTASE domain-containing protein. (173 aa)
	APZ42_001817	Low-density lipoprotein receptor-related protein 2. (214 aa)
	APZ42_001299	Putative Cubilin. (186 aa)
	APZ42_034371	Vitellogenin receptor. (1763 aa)
	APZ42_033882	Putative Lysosomal cobalamin transporter. (569 aa)
	APZ42_032705	Androgen-induced gene 1 protein. (172 aa)
	APZ42_030633	Ankyrin repeat domain-containing protein 16. (337 aa)
	APZ42_028941	Low-density lipoprotein receptor-related protein 2. (4788 aa)
	APZ42_024586	Uncharacterized protein. (438 aa)
	APZ42_024105	Low-density lipoprotein receptor-related protein 2. (4941 aa)
	APZ42_019781	Cubilin-like protein. (715 aa)
	APZ42_019106	Putative Basement membrane-specific heparan sulfate proteoglycan core protein. (575 aa)
	APZ42_016632	ABC protein, subfamily ABCD. (612 aa)
	APZ42_016204	Uncharacterized protein. (913 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_000750	APZ42_024152	A0A162C8X5	A0A0N7ZGQ4	Cubilin.	Uncharacterized protein.	0.611
APZ42_000750	APZ42_024586	A0A162C8X5	A0A164TZR6	Cubilin.	Uncharacterized protein.	0.611
APZ42_000750	APZ42_028750	A0A162C8X5	A0A0P5Z7R4	Cubilin.	Uncharacterized protein.	0.611
APZ42_000750	APZ42_031701	A0A162C8X5	A0A0P5VSL4	Cubilin.	Protein amnionless.	0.800
APZ42_001299	APZ42_024152	A0A164J2K5	A0A0N7ZGQ4	Putative Cubilin.	Uncharacterized protein.	0.611
APZ42_001299	APZ42_024586	A0A164J2K5	A0A164TZR6	Putative Cubilin.	Uncharacterized protein.	0.611
APZ42_001299	APZ42_028750	A0A164J2K5	A0A0P5Z7R4	Putative Cubilin.	Uncharacterized protein.	0.611
APZ42_001299	APZ42_031701	A0A164J2K5	A0A0P5VSL4	Putative Cubilin.	Protein amnionless.	0.800
APZ42_001817	APZ42_010850	A0A164IQA7	A0A162T8L4	Low-density lipoprotein receptor-related protein 2.	Putative Vitellogenin receptor.	0.624
APZ42_001817	APZ42_013388	A0A164IQA7	A0A162QYY2	Low-density lipoprotein receptor-related protein 2.	Putative Basement membrane-specific heparan sulfate proteoglycan core protein.	0.627
APZ42_001817	APZ42_016204	A0A164IQA7	A0A165AJC7	Low-density lipoprotein receptor-related protein 2.	Uncharacterized protein.	0.627
APZ42_001817	APZ42_019106	A0A164IQA7	A0A164YKH6	Low-density lipoprotein receptor-related protein 2.	Putative Basement membrane-specific heparan sulfate proteoglycan core protein.	0.627
APZ42_001817	APZ42_024105	A0A164IQA7	A0A164UH83	Low-density lipoprotein receptor-related protein 2.	Low-density lipoprotein receptor-related protein 2.	0.903
APZ42_001817	APZ42_024152	A0A164IQA7	A0A0N7ZGQ4	Low-density lipoprotein receptor-related protein 2.	Uncharacterized protein.	0.597
APZ42_001817	APZ42_024586	A0A164IQA7	A0A164TZR6	Low-density lipoprotein receptor-related protein 2.	Uncharacterized protein.	0.597
APZ42_001817	APZ42_028750	A0A164IQA7	A0A0P5Z7R4	Low-density lipoprotein receptor-related protein 2.	Uncharacterized protein.	0.597
APZ42_001817	APZ42_034371	A0A164IQA7	A0A164K5K2	Low-density lipoprotein receptor-related protein 2.	Vitellogenin receptor.	0.659
APZ42_002157	APZ42_013795	A0A164IGS1	A0A0P5ZHS0	METMALONYL_COA_MUTASE domain-containing protein.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.438
APZ42_002157	APZ42_016632	A0A164IGS1	A0A165ABA9	METMALONYL_COA_MUTASE domain-containing protein.	ABC protein, subfamily ABCD.	0.410
APZ42_002157	APZ42_019315	A0A164IGS1	A0A0P4X6J2	METMALONYL_COA_MUTASE domain-containing protein.	Methylmalonic aciduria and homocystinuria type D protein, mitochondrial.	0.439