(38 nodes) Vitamin D (calciferol) metabolism network (Daphnia magna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APZ42_019407	Putative Cytochrome P450 4d21; Belongs to the cytochrome P450 family. (555 aa)
	APZ42_015155	E3 SUMO-protein ligase PIAS1. (674 aa)
	APZ42_027305	Peroxisome proliferator-activated receptor delta. (722 aa)
	APZ42_017615	Cytochrome P450 315a1, mitochondrial; Belongs to the cytochrome P450 family. (491 aa)
	APZ42_027303	Retinoid x receptor. (699 aa)
	APZ42_019406	Putative Cytochrome P450 4d20; Belongs to the cytochrome P450 family. (526 aa)
	APZ42_026730	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (163 aa)
	APZ42_015809	Cytochrome P450 2U1; Belongs to the cytochrome P450 family. (551 aa)
	APZ42_021100	Cytochrome P450 305a1; Belongs to the cytochrome P450 family. (502 aa)
	APZ42_024580	Retinoid x receptor. (463 aa)
	APZ42_012187	Retinoid x receptor. (402 aa)
	APZ42_020113	Cytochrome p450. (379 aa)
	APZ42_032642	Nuclear hormone receptor HR96. (522 aa)
	APZ42_019401	Putative Cytochrome P450 4d20; Belongs to the cytochrome P450 family. (526 aa)
	APZ42_028739	Putative Cytochrome P450 305a1; Belongs to the cytochrome P450 family. (503 aa)
	APZ42_018036	Cytochrome P450 4B1; Belongs to the cytochrome P450 family. (514 aa)
	APZ42_000750	Cubilin. (527 aa)
	APZ42_019404	Putative Cytochrome P450 4d20; Belongs to the cytochrome P450 family. (546 aa)
	APZ42_029176	Putative Cubilin. (72 aa)
	APZ42_004252	Uncharacterized protein. (135 aa)
	APZ42_001299	Putative Cubilin. (186 aa)
	APZ42_001263	Uncharacterized protein. (135 aa)
	APZ42_000401	Uncharacterized protein. (127 aa)
	APZ42_032459	Cytochrome P450. (478 aa)
	APZ42_028687	Lanosterol 14-alpha demethylase. (1531 aa)
	APZ42_017649	Lanosterol 14-alpha demethylase; Belongs to the cytochrome P450 family. (509 aa)
	APZ42_028681	Putative Cytochrome P450 305a1; Belongs to the cytochrome P450 family. (489 aa)
	APZ42_028691	Putative Cytochrome P450 304a1; Belongs to the cytochrome P450 family. (498 aa)
	APZ42_028083	Cytochrome P450 4d8; Belongs to the cytochrome P450 family. (545 aa)
	APZ42_027686	Cytochrome p450-like protein. (320 aa)
	APZ42_027006	Uncharacterized protein; Belongs to the cytochrome P450 family. (592 aa)
	APZ42_027005	Uncharacterized protein; Belongs to the cytochrome P450 family. (451 aa)
	APZ42_022367	Putative Cytochrome P450 4aa1; Belongs to the cytochrome P450 family. (527 aa)
	APZ42_022384	Uncharacterized protein. (461 aa)
	APZ42_022682	Cholesterol 24-hydroxylase. (861 aa)
	APZ42_021108	Putative Cytochrome P450 304a1; Belongs to the cytochrome P450 family. (524 aa)
	APZ42_019781	Cubilin-like protein. (715 aa)
	APZ42_019414	Cytochrome P450 26C1; Belongs to the cytochrome P450 family. (513 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_000401	APZ42_017615	A0A164JPD9	A0A0P5E5C4	Uncharacterized protein.	Cytochrome P450 315a1, mitochondrial; Belongs to the cytochrome P450 family.	0.497
APZ42_001263	APZ42_017615	A0A164J382	A0A0P5E5C4	Uncharacterized protein.	Cytochrome P450 315a1, mitochondrial; Belongs to the cytochrome P450 family.	0.497
APZ42_004252	APZ42_017615	A0A162F0S0	A0A0P5E5C4	Uncharacterized protein.	Cytochrome P450 315a1, mitochondrial; Belongs to the cytochrome P450 family.	0.497
APZ42_012187	APZ42_015155	A0A0P5WD63	A0A0N8DA50	Retinoid x receptor.	E3 SUMO-protein ligase PIAS1.	0.405
APZ42_012187	APZ42_026730	A0A0P5WD63	A0A0P5SVZ9	Retinoid x receptor.	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	0.578
APZ42_015155	APZ42_012187	A0A0N8DA50	A0A0P5WD63	E3 SUMO-protein ligase PIAS1.	Retinoid x receptor.	0.405
APZ42_015155	APZ42_024580	A0A0N8DA50	A0A0P5VI40	E3 SUMO-protein ligase PIAS1.	Retinoid x receptor.	0.405
APZ42_015155	APZ42_026730	A0A0N8DA50	A0A0P5SVZ9	E3 SUMO-protein ligase PIAS1.	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family.	0.993
APZ42_015155	APZ42_027303	A0A0N8DA50	A0A0P5F6Q5	E3 SUMO-protein ligase PIAS1.	Retinoid x receptor.	0.405
APZ42_015155	APZ42_027305	A0A0N8DA50	A0A0P5CZ96	E3 SUMO-protein ligase PIAS1.	Peroxisome proliferator-activated receptor delta.	0.405
APZ42_015155	APZ42_032642	A0A0N8DA50	A0A0P5XKS8	E3 SUMO-protein ligase PIAS1.	Nuclear hormone receptor HR96.	0.405
APZ42_015809	APZ42_017615	A0A0P5TH49	A0A0P5E5C4	Cytochrome P450 2U1; Belongs to the cytochrome P450 family.	Cytochrome P450 315a1, mitochondrial; Belongs to the cytochrome P450 family.	0.676
APZ42_015809	APZ42_017649	A0A0P5TH49	A0A164ZZS4	Cytochrome P450 2U1; Belongs to the cytochrome P450 family.	Lanosterol 14-alpha demethylase; Belongs to the cytochrome P450 family.	0.472
APZ42_015809	APZ42_018036	A0A0P5TH49	A0A0P5Z3X7	Cytochrome P450 2U1; Belongs to the cytochrome P450 family.	Cytochrome P450 4B1; Belongs to the cytochrome P450 family.	0.477
APZ42_015809	APZ42_019401	A0A0P5TH49	A0A0P5XSD0	Cytochrome P450 2U1; Belongs to the cytochrome P450 family.	Putative Cytochrome P450 4d20; Belongs to the cytochrome P450 family.	0.479
APZ42_015809	APZ42_019404	A0A0P5TH49	A0A162CEN7	Cytochrome P450 2U1; Belongs to the cytochrome P450 family.	Putative Cytochrome P450 4d20; Belongs to the cytochrome P450 family.	0.478
APZ42_015809	APZ42_019406	A0A0P5TH49	A0A0P5HCU9	Cytochrome P450 2U1; Belongs to the cytochrome P450 family.	Putative Cytochrome P450 4d20; Belongs to the cytochrome P450 family.	0.479
APZ42_015809	APZ42_019407	A0A0P5TH49	A0A164Y5A3	Cytochrome P450 2U1; Belongs to the cytochrome P450 family.	Putative Cytochrome P450 4d21; Belongs to the cytochrome P450 family.	0.474
APZ42_015809	APZ42_019414	A0A0P5TH49	A0A164Y594	Cytochrome P450 2U1; Belongs to the cytochrome P450 family.	Cytochrome P450 26C1; Belongs to the cytochrome P450 family.	0.482
APZ42_015809	APZ42_022367	A0A0P5TH49	A0A164VG20	Cytochrome P450 2U1; Belongs to the cytochrome P450 family.	Putative Cytochrome P450 4aa1; Belongs to the cytochrome P450 family.	0.482