(50 nodes) Negative regulation of the PI3K/AKT network network (Daphnia magna)

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	APZ42_024857	Receptor protein-tyrosine kinase. (1535 aa)
	APZ42_025382	Vav protein. (172 aa)
	APZ42_027128	Uncharacterized protein. (667 aa)
	APZ42_029209	Putative Tribbles protein. (382 aa)
	APZ42_030441	Tyrosine-protein kinase STYK1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1155 aa)
	APZ42_030677	Putative Phosphoinositide 3-kinase adapter protein 1. (1305 aa)
	APZ42_016447	Insulin receptor substrate 1-like protein. (1672 aa)
	APZ42_018079	Inscuteable. (324 aa)
	APZ42_019289	Fibroblast growth factor receptor. (757 aa)
	APZ42_030932	Lactase-phlorizin hydrolase; Belongs to the glycosyl hydrolase 1 family. (510 aa)
	APZ42_031044	Interleukin-1 receptor-associated kinase 4. (491 aa)
	APZ42_031866	Putative Serine/threonine-protein phosphatase 4 regulatory subunit 4. (646 aa)
	APZ42_032195	Pro-neuregulin-2, membrane-bound-like protein. (466 aa)
	APZ42_032339	Ret oncogene; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1114 aa)
	APZ42_002734	Pro-neuregulin-2, membrane-bound. (63 aa)
	APZ42_011762	Putative Serine/threonine-protein phosphatase 4 regulatory subunit 1. (839 aa)
	APZ42_019443	Enhancer of sevenless 2B protein. (211 aa)
	APZ42_011559	LisH domain and HEAT repeat-containing protein. (413 aa)
	APZ42_013134	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit Delta; Belongs to the PI3/PI4-kinase family. (658 aa)
	APZ42_013130	Phosphatidylinositol 3-kinase catalytic subunit type 3; Belongs to the PI3/PI4-kinase family. (1116 aa)
	APZ42_013831	Non-specific serine/threonine protein kinase. (532 aa)
	APZ42_016056	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (863 aa)
	APZ42_030893	Putative Lactase-phlorizin hydrolase; Belongs to the glycosyl hydrolase 1 family. (655 aa)
	APZ42_030042	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha. (590 aa)
	APZ42_018129	Tyrosine-protein kinase receptor. (2351 aa)
	APZ42_002931	SAM domain-containing protein. (59 aa)
	APZ42_032307	Putative GRB2-associated-binding protein 2. (630 aa)
	APZ42_013799	Estrogen-related receptor splice variant. (599 aa)
	APZ42_021327	Fibronectin type III domain-containing protein 3B. (1146 aa)
	APZ42_032316	Fibroblast growth factor receptor substrate. (500 aa)
	APZ42_030929	Lactase-phlorizin hydrolase; Belongs to the glycosyl hydrolase 1 family. (502 aa)
	APZ42_013220	Leucine-rich repeat protein 1. (405 aa)
	APZ42_032827	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (611 aa)
	APZ42_030790	Interleukin-1 receptor-associated kinase 4. (703 aa)
	APZ42_011348	Protein FAM102B. (430 aa)
	APZ42_019724	Serine/threonine-protein phosphatase. (309 aa)
	APZ42_015149	Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (476 aa)
	APZ42_017922	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta. (811 aa)
	APZ42_017416	Coiled-coil domain-containing protein 137. (295 aa)
	APZ42_015145	Striatin-3. (780 aa)
	APZ42_015376	Lactase-phlorizin hydrolase; Belongs to the glycosyl hydrolase 1 family. (503 aa)
	APZ42_025380	Guanine nucleotide exchange factor VAV2. (546 aa)
	APZ42_014697	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta. (454 aa)
	APZ42_019402	Putative Derailed 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (906 aa)
	APZ42_022191	Putative Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2. (610 aa)
	APZ42_022879	WW domain-containing protein. (526 aa)
	APZ42_022330	Guanine nucleotide exchange factor VAV3. (805 aa)
	APZ42_022930	Phosphatidylinositol 5-phosphate 4-kinase. (2111 aa)
	APZ42_024029	Phosphatidylinositol 3-kinase regulatory subunit gamma. (409 aa)
	APZ42_023798	Pi3K21B. (782 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_002734	APZ42_011559	A0A164I2R4	A0A162SS60	Pro-neuregulin-2, membrane-bound.	LisH domain and HEAT repeat-containing protein.	0.523
APZ42_002734	APZ42_011762	A0A164I2R4	A0A162SZN5	Pro-neuregulin-2, membrane-bound.	Putative Serine/threonine-protein phosphatase 4 regulatory subunit 1.	0.523
APZ42_002734	APZ42_013130	A0A164I2R4	A0A162R1L1	Pro-neuregulin-2, membrane-bound.	Phosphatidylinositol 3-kinase catalytic subunit type 3; Belongs to the PI3/PI4-kinase family.	0.577
APZ42_002734	APZ42_013134	A0A164I2R4	A0A162R1M2	Pro-neuregulin-2, membrane-bound.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit Delta; Belongs to the PI3/PI4-kinase family.	0.577
APZ42_002734	APZ42_019443	A0A164I2R4	A0A164Y7E8	Pro-neuregulin-2, membrane-bound.	Enhancer of sevenless 2B protein.	0.627
APZ42_002734	APZ42_019724	A0A164I2R4	A0A0P5NDB5	Pro-neuregulin-2, membrane-bound.	Serine/threonine-protein phosphatase.	0.582
APZ42_002734	APZ42_022879	A0A164I2R4	A0A164VWU9	Pro-neuregulin-2, membrane-bound.	WW domain-containing protein.	0.523
APZ42_002734	APZ42_024857	A0A164I2R4	A0A164TND3	Pro-neuregulin-2, membrane-bound.	Receptor protein-tyrosine kinase.	0.969
APZ42_002734	APZ42_030042	A0A164I2R4	A0A162D3M9	Pro-neuregulin-2, membrane-bound.	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha.	0.523
APZ42_002734	APZ42_030790	A0A164I2R4	A0A0P5T3L4	Pro-neuregulin-2, membrane-bound.	Interleukin-1 receptor-associated kinase 4.	0.462
APZ42_002734	APZ42_031044	A0A164I2R4	A0A164N707	Pro-neuregulin-2, membrane-bound.	Interleukin-1 receptor-associated kinase 4.	0.462
APZ42_002734	APZ42_031866	A0A164I2R4	A0A164MGZ5	Pro-neuregulin-2, membrane-bound.	Putative Serine/threonine-protein phosphatase 4 regulatory subunit 4.	0.523
APZ42_002931	APZ42_013130	A0A162C3Y1	A0A162R1L1	SAM domain-containing protein.	Phosphatidylinositol 3-kinase catalytic subunit type 3; Belongs to the PI3/PI4-kinase family.	0.932
APZ42_002931	APZ42_013134	A0A162C3Y1	A0A162R1M2	SAM domain-containing protein.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit Delta; Belongs to the PI3/PI4-kinase family.	0.932
APZ42_002931	APZ42_013220	A0A162C3Y1	A0A0P5VPJ5	SAM domain-containing protein.	Leucine-rich repeat protein 1.	0.510
APZ42_002931	APZ42_013799	A0A162C3Y1	A0A0P6ASE0	SAM domain-containing protein.	Estrogen-related receptor splice variant.	0.576
APZ42_002931	APZ42_013831	A0A162C3Y1	A0A162QGI2	SAM domain-containing protein.	Non-specific serine/threonine protein kinase.	0.772
APZ42_002931	APZ42_014697	A0A162C3Y1	A0A0P5BP85	SAM domain-containing protein.	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta.	0.690
APZ42_002931	APZ42_016056	A0A162C3Y1	A0A162NK25	SAM domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.594
APZ42_002931	APZ42_016447	A0A162C3Y1	A0A165AFH6	SAM domain-containing protein.	Insulin receptor substrate 1-like protein.	0.953