(20 nodes) Notch-HLH transcription pathway network (Daphnia magna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APZ42_020180	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (392 aa)
	APZ42_020282	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1140 aa)
	APZ42_018957	F-box/WD repeat-containing TBL1XR1-like protein. (373 aa)
	APZ42_026807	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (434 aa)
	APZ42_026768	Puff-specific protein Bx42. (544 aa)
	APZ42_021069	Hdac6. (57 aa)
	APZ42_034380	F-box/WD repeat-containing protein TBL1XR1. (492 aa)
	APZ42_015851	Wd-repeat protein. (392 aa)
	APZ42_012709	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (540 aa)
	APZ42_031956	F-box/WD repeat-containing TBL1XR1-like protein. (735 aa)
	APZ42_019853	Nuclear receptor corepressor. (2125 aa)
	APZ42_015896	WD repeat-containing protein 53. (396 aa)
	APZ42_016062	Putative wd-repeat protein. (376 aa)
	APZ42_014559	Histone deacetylase 6-like protein. (313 aa)
	APZ42_002704	Recombining binding protein suppressor of hairless. (127 aa)
	APZ42_000788	Putative Recombining binding protein suppressor of hairless. (118 aa)
	APZ42_030032	Putative Hdac6. (446 aa)
	APZ42_028561	Putative Histone deacetylase HDAC6 protein. (1041 aa)
	APZ42_023336	Recombining binding protein suppressor of hairless. (577 aa)
	APZ42_003663	Uncharacterized protein. (76 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_000788	APZ42_003663	A0A164JDM5	A0A168EL79	Putative Recombining binding protein suppressor of hairless.	Uncharacterized protein.	0.515
APZ42_000788	APZ42_012709	A0A164JDM5	A0A0P5V584	Putative Recombining binding protein suppressor of hairless.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.873
APZ42_000788	APZ42_014559	A0A164JDM5	A0A162PQP9	Putative Recombining binding protein suppressor of hairless.	Histone deacetylase 6-like protein.	0.612
APZ42_000788	APZ42_015851	A0A164JDM5	A0A0P5TDK4	Putative Recombining binding protein suppressor of hairless.	Wd-repeat protein.	0.515
APZ42_000788	APZ42_015896	A0A164JDM5	A0A162NEF8	Putative Recombining binding protein suppressor of hairless.	WD repeat-containing protein 53.	0.515
APZ42_000788	APZ42_016062	A0A164JDM5	A0A162NJW1	Putative Recombining binding protein suppressor of hairless.	Putative wd-repeat protein.	0.515
APZ42_000788	APZ42_018957	A0A164JDM5	A0A0P5CYP5	Putative Recombining binding protein suppressor of hairless.	F-box/WD repeat-containing TBL1XR1-like protein.	0.515
APZ42_000788	APZ42_019853	A0A164JDM5	A0A0P6A9W1	Putative Recombining binding protein suppressor of hairless.	Nuclear receptor corepressor.	0.804
APZ42_000788	APZ42_020180	A0A164JDM5	A0A0P4XN91	Putative Recombining binding protein suppressor of hairless.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.677
APZ42_000788	APZ42_020282	A0A164JDM5	A0A0P5BZJ2	Putative Recombining binding protein suppressor of hairless.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.612
APZ42_000788	APZ42_021069	A0A164JDM5	A0A0P5J723	Putative Recombining binding protein suppressor of hairless.	Hdac6.	0.612
APZ42_000788	APZ42_026768	A0A164JDM5	A0A0P5IWP5	Putative Recombining binding protein suppressor of hairless.	Puff-specific protein Bx42.	0.806
APZ42_000788	APZ42_026807	A0A164JDM5	A0A0P5EVU3	Putative Recombining binding protein suppressor of hairless.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.677
APZ42_000788	APZ42_028561	A0A164JDM5	A0A164Q769	Putative Recombining binding protein suppressor of hairless.	Putative Histone deacetylase HDAC6 protein.	0.612
APZ42_000788	APZ42_030032	A0A164JDM5	A0A164P459	Putative Recombining binding protein suppressor of hairless.	Putative Hdac6.	0.612
APZ42_000788	APZ42_031956	A0A164JDM5	A0A0P5Z1P0	Putative Recombining binding protein suppressor of hairless.	F-box/WD repeat-containing TBL1XR1-like protein.	0.515
APZ42_000788	APZ42_034380	A0A164JDM5	A0A0P5QL58	Putative Recombining binding protein suppressor of hairless.	F-box/WD repeat-containing protein TBL1XR1.	0.515
APZ42_002704	APZ42_003663	A0A164I3H5	A0A168EL79	Recombining binding protein suppressor of hairless.	Uncharacterized protein.	0.515
APZ42_002704	APZ42_012709	A0A164I3H5	A0A0P5V584	Recombining binding protein suppressor of hairless.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.873
APZ42_002704	APZ42_014559	A0A164I3H5	A0A162PQP9	Recombining binding protein suppressor of hairless.	Histone deacetylase 6-like protein.	0.612