(26 nodes) Nonhomologous End-Joining (NHEJ) network (Daphnia magna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APZ42_018475	X-ray repair cross-complementing protein 5. (122 aa)
	APZ42_027118	Uncharacterized protein. (698 aa)
	APZ42_030747	RING-type domain-containing protein. (321 aa)
	APZ42_033958	Reverse transcriptase domain-containing protein. (483 aa)
	APZ42_034183	Reverse transcriptase domain-containing protein. (366 aa)
	APZ42_005834	RING-type domain-containing protein. (348 aa)
	APZ42_011389	Tyrosyl-DNA phosphodiesterase 2. (358 aa)
	APZ42_011260	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (381 aa)
	APZ42_012978	Lys-63-specific deubiquitinase BRCC36. (246 aa)
	APZ42_013658	BRCT domain-containing protein. (1286 aa)
	APZ42_023887	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (146 aa)
	APZ42_023167	DNA ligase 4; Belongs to the ATP-dependent DNA ligase family. (891 aa)
	APZ42_016503	BRCT domain-containing protein; Belongs to the DNA polymerase type-X family. (538 aa)
	APZ42_013620	DNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family. (3687 aa)
	APZ42_014340	Myotrophin. (770 aa)
	APZ42_015559	Putative BRCA1-A complex subunit BRE. (368 aa)
	APZ42_024255	RING-type domain-containing protein. (189 aa)
	APZ42_031466	Reverse transcriptase domain-containing protein. (422 aa)
	APZ42_026453	Uncharacterized protein. (390 aa)
	APZ42_030575	RING-type domain-containing protein. (460 aa)
	APZ42_001774	Uncharacterized protein. (97 aa)
	APZ42_004607	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	APZ42_012372	Putative DNA cross-link repair protein pso2/snm1. (385 aa)
	APZ42_032643	Putative Tyrosyl-DNA phosphodiesterase. (580 aa)
	APZ42_022302	Non-ous end-joining factor 1. (281 aa)
	APZ42_031507	Breast and ovarian cancer sususceptibility protein. (952 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_001774	APZ42_004607	A0A162CZU8	A0A0P6INX3	Uncharacterized protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.770
APZ42_001774	APZ42_011260	A0A162CZU8	A0A162SIV5	Uncharacterized protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.770
APZ42_001774	APZ42_013658	A0A162CZU8	A0A162QR19	Uncharacterized protein.	BRCT domain-containing protein.	0.561
APZ42_001774	APZ42_018475	A0A162CZU8	A0A164Z2S1	Uncharacterized protein.	X-ray repair cross-complementing protein 5.	0.579
APZ42_001774	APZ42_023887	A0A162CZU8	A0A164U839	Uncharacterized protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.770
APZ42_004607	APZ42_001774	A0A0P6INX3	A0A162CZU8	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Uncharacterized protein.	0.770
APZ42_004607	APZ42_012372	A0A0P6INX3	A0A0P5ZJZ3	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Putative DNA cross-link repair protein pso2/snm1.	0.606
APZ42_004607	APZ42_012978	A0A0P6INX3	A0A162RAI6	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Lys-63-specific deubiquitinase BRCC36.	0.568
APZ42_004607	APZ42_013620	A0A0P6INX3	A0A162QPJ7	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	DNA-dependent protein kinase catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.636
APZ42_004607	APZ42_013658	A0A0P6INX3	A0A162QR19	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	BRCT domain-containing protein.	0.850
APZ42_004607	APZ42_014340	A0A0P6INX3	A0A162Q7W5	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Myotrophin.	0.741
APZ42_004607	APZ42_015559	A0A0P6INX3	A0A162NUZ3	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Putative BRCA1-A complex subunit BRE.	0.601
APZ42_004607	APZ42_018475	A0A0P6INX3	A0A164Z2S1	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	X-ray repair cross-complementing protein 5.	0.713
APZ42_004607	APZ42_030575	A0A0P6INX3	A0A162D2T0	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	RING-type domain-containing protein.	0.580
APZ42_004607	APZ42_031466	A0A0P6INX3	A0A162DBG1	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Reverse transcriptase domain-containing protein.	0.545
APZ42_004607	APZ42_031507	A0A0P6INX3	A0A0N8DAA0	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Breast and ovarian cancer sususceptibility protein.	0.695
APZ42_004607	APZ42_033958	A0A0P6INX3	A0A164KKB5	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Reverse transcriptase domain-containing protein.	0.580
APZ42_004607	APZ42_034183	A0A0P6INX3	A0A164KDQ7	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	Reverse transcriptase domain-containing protein.	0.521
APZ42_005834	APZ42_012372	A0A164G8D1	A0A0P5ZJZ3	RING-type domain-containing protein.	Putative DNA cross-link repair protein pso2/snm1.	0.556
APZ42_005834	APZ42_012978	A0A164G8D1	A0A162RAI6	RING-type domain-containing protein.	Lys-63-specific deubiquitinase BRCC36.	0.595