(19 nodes) VLDLR internalisation and degradation network (Daphnia magna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APZ42_031217	Oxysterols receptor LXR-alpha. (385 aa)
	APZ42_015989	E3 ubiquitin-protein ligase MYLIP. (469 aa)
	APZ42_015608	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. (943 aa)
	APZ42_019770	Low-density lipoprotein receptor. (834 aa)
	APZ42_020788	AP complex subunit beta. (927 aa)
	APZ42_020216	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (228 aa)
	APZ42_018911	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1663 aa)
	APZ42_005840	Polyubiquitin-B. (124 aa)
	APZ42_016204	Uncharacterized protein. (913 aa)
	APZ42_019106	Putative Basement membrane-specific heparan sulfate proteoglycan core protein. (575 aa)
	APZ42_021443	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family. (415 aa)
	APZ42_021729	Polyubiquitin-B. (611 aa)
	APZ42_031040	Ubiquitin-60S ribosomal protein L40. (128 aa)
	APZ42_034371	Vitellogenin receptor. (1763 aa)
	APZ42_005620	Ubiquitin-40S ribosomal protein S27a. (122 aa)
	APZ42_010850	Putative Vitellogenin receptor. (1351 aa)
	APZ42_013388	Putative Basement membrane-specific heparan sulfate proteoglycan core protein. (1513 aa)
	APZ42_014763	Bile acid receptor. (657 aa)
	APZ42_016099	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_005620	APZ42_005840	A0A164GCP6	A0A162CSN9	Ubiquitin-40S ribosomal protein S27a.	Polyubiquitin-B.	0.979
APZ42_005620	APZ42_010850	A0A164GCP6	A0A162T8L4	Ubiquitin-40S ribosomal protein S27a.	Putative Vitellogenin receptor.	0.538
APZ42_005620	APZ42_014763	A0A164GCP6	A0A162PLH6	Ubiquitin-40S ribosomal protein S27a.	Bile acid receptor.	0.653
APZ42_005620	APZ42_015608	A0A164GCP6	A0A0P5KQ01	Ubiquitin-40S ribosomal protein S27a.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.713
APZ42_005620	APZ42_015989	A0A164GCP6	A0A162NJ05	Ubiquitin-40S ribosomal protein S27a.	E3 ubiquitin-protein ligase MYLIP.	0.816
APZ42_005620	APZ42_018911	A0A164GCP6	A0A162CQ61	Ubiquitin-40S ribosomal protein S27a.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.718
APZ42_005620	APZ42_019770	A0A164GCP6	A0A0P6A4R1	Ubiquitin-40S ribosomal protein S27a.	Low-density lipoprotein receptor.	0.418
APZ42_005620	APZ42_020216	A0A164GCP6	A0A162CEI2	Ubiquitin-40S ribosomal protein S27a.	Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.	0.679
APZ42_005620	APZ42_020788	A0A164GCP6	A0A0P6DXK2	Ubiquitin-40S ribosomal protein S27a.	AP complex subunit beta.	0.716
APZ42_005620	APZ42_021443	A0A164GCP6	A0A164WPI1	Ubiquitin-40S ribosomal protein S27a.	AP-2 complex subunit mu-1; Belongs to the adaptor complexes medium subunit family.	0.720
APZ42_005620	APZ42_021729	A0A164GCP6	A0A164WHS6	Ubiquitin-40S ribosomal protein S27a.	Polyubiquitin-B.	0.978
APZ42_005620	APZ42_031040	A0A164GCP6	A0A164N724	Ubiquitin-40S ribosomal protein S27a.	Ubiquitin-60S ribosomal protein L40.	0.999
APZ42_005620	APZ42_031217	A0A164GCP6	A0A0P4YJK8	Ubiquitin-40S ribosomal protein S27a.	Oxysterols receptor LXR-alpha.	0.653
APZ42_005620	APZ42_034371	A0A164GCP6	A0A164K5K2	Ubiquitin-40S ribosomal protein S27a.	Vitellogenin receptor.	0.538
APZ42_005840	APZ42_005620	A0A162CSN9	A0A164GCP6	Polyubiquitin-B.	Ubiquitin-40S ribosomal protein S27a.	0.979
APZ42_005840	APZ42_014763	A0A162CSN9	A0A162PLH6	Polyubiquitin-B.	Bile acid receptor.	0.555
APZ42_005840	APZ42_015608	A0A162CSN9	A0A0P5KQ01	Polyubiquitin-B.	AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.	0.701
APZ42_005840	APZ42_015989	A0A162CSN9	A0A162NJ05	Polyubiquitin-B.	E3 ubiquitin-protein ligase MYLIP.	0.731
APZ42_005840	APZ42_016099	A0A162CSN9	A0A162NMK5	Polyubiquitin-B.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.672
APZ42_005840	APZ42_018911	A0A162CSN9	A0A162CQ61	Polyubiquitin-B.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.734