(64 nodes) Transcriptional regulation by RUNX2 network (Daphnia magna)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	EOG090X09LQ	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (257 aa)
	APZ42_027416	26S proteasome non-ATPase regulatory subunit 14. (311 aa)
	APZ42_014562	26S proteasome non-ATPase regulatory subunit 9. (203 aa)
	APZ42_033484	Proteasome subunit beta. (234 aa)
	APZ42_017923	Proteasome subunit beta. (276 aa)
	APZ42_029254	Transcription factor SOX-8-like protein. (606 aa)
	EOG090X0AJZ	STIP1 Y and U box-containing protein 1. (276 aa)
	EOG090X0511	Putative Neurogenin-3. (297 aa)
	APZ42_016295	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (242 aa)
	APZ42_031728	Putative 26S proteasome non-ATPase regulatory subunit 3. (496 aa)
	APZ42_030562	Proteasome activator complex subunit 3. (242 aa)
	APZ42_021386	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (255 aa)
	APZ42_028069	26S proteasome regulatory complex subunit p48B; Belongs to the AAA ATPase family. (434 aa)
	EOG090X0CE5	Proteasome subunit beta. (205 aa)
	APZ42_019766	G2/mitotic-specific cyclin B, copy B-like protein; Belongs to the cyclin family. (410 aa)
	APZ42_023129	Pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial. (575 aa)
	APZ42_021635	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (234 aa)
	APZ42_025595	Proteasome subunit beta. (226 aa)
	APZ42_023690	Heart-and neural crest derivatives-expressed protein. (289 aa)
	APZ42_034381	26S proteasome non-ATPase regulatory subunit 8. (265 aa)
	APZ42_011152	Transcription factor runt-like protein. (495 aa)
	APZ42_014874	Proteasome inhibitor PI31 subunit. (265 aa)
	EOG090X05V9	26S proteasome non-ATPase regulatory subunit 13. (379 aa)
	APZ42_028388	26S proteasome non-ATPase regulatory subunit 6. (389 aa)
	APZ42_026380	Proteasome subunit beta; Belongs to the peptidase T1B family. (262 aa)
	APZ42_030556	G2/mitotic-specific cyclin protein, copy A; Belongs to the cyclin family. (420 aa)
	APZ42_020152	26S proteasome non-ATPase regulatory subunit 11B. (411 aa)
	APZ42_031545	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (929 aa)
	APZ42_013799	Estrogen-related receptor splice variant. (599 aa)
	APZ42_028336	Core-binding factor subunit beta. (233 aa)
	APZ42_022784	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (285 aa)
	APZ42_019436	26S Protease regulatory subunit 4; Belongs to the AAA ATPase family. (442 aa)
	APZ42_031391	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (162 aa)
	APZ42_024450	26S protease regulatory subunit 6A; Belongs to the AAA ATPase family. (430 aa)
	APZ42_017932	26S proteasome non-ATPase regulatory subunit 5. (480 aa)
	APZ42_005840	Polyubiquitin-B. (124 aa)
	APZ42_031074	Putative Shn zinc finger protein. (1642 aa)
	APZ42_015341	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (250 aa)
	APZ42_014756	Regulatory particle triple-A ATPase 6-related protein; Belongs to the AAA ATPase family. (404 aa)
	APZ42_013012	Proteasome subunit beta. (274 aa)
	APZ42_010934	Transcription factor runt-like protein. (182 aa)
	APZ42_005620	Ubiquitin-40S ribosomal protein S27a. (122 aa)
	APZ42_004212	26S proteasome non-ATPase regulatory subunit 7. (313 aa)
	APZ42_034375	26S Protease regulatory subunit 10B; Belongs to the AAA ATPase family. (389 aa)
	APZ42_033997	Putative Cyclin-dependent kinase 6. (263 aa)
	APZ42_033104	Putative Homeobox expressed in ES cells 1. (628 aa)
	APZ42_032633	RING-box protein 1A. (116 aa)
	APZ42_032247	26S Protease regulatory subunit 6B-like protein. (217 aa)
	APZ42_031733	Mothers against decapentaplegic homolog. (653 aa)
	APZ42_031040	Ubiquitin-60S ribosomal protein L40. (128 aa)
	APZ42_030508	26S Protease regulatory subunit 6B; Belongs to the AAA ATPase family. (417 aa)
	APZ42_029320	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (246 aa)
	APZ42_028630	Proteasome subunit beta type-1. (230 aa)
	EOG090X08NC	26S proteasome non-ATPase regulatory subunit 4. (388 aa)
	APZ42_028305	Cyclin_C domain-containing protein. (191 aa)
	APZ42_028141	Cyclin D, copy B-like protein; Belongs to the cyclin family. (176 aa)
	APZ42_023256	Putative G1/S-specific cyclin-D3; Belongs to the cyclin family. (221 aa)
	APZ42_021729	Polyubiquitin-B. (611 aa)
	APZ42_020324	Putative Transcription factor HES-2. (590 aa)
	APZ42_017914	Cullin-5; Belongs to the cullin family. (779 aa)
	EOG090X04UV	26S proteasome non-ATPase regulatory subunit 12. (466 aa)
	APZ42_017595	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (948 aa)
	APZ42_016769	S-phase kinase-associated protein. (424 aa)
	APZ42_019459	Hairy enhancer of split-like 1. (235 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_004212	APZ42_005620	A0A164H788	A0A164GCP6	26S proteasome non-ATPase regulatory subunit 7.	Ubiquitin-40S ribosomal protein S27a.	0.983
APZ42_004212	APZ42_005840	A0A164H788	A0A162CSN9	26S proteasome non-ATPase regulatory subunit 7.	Polyubiquitin-B.	0.956
APZ42_004212	APZ42_013012	A0A164H788	A0A162R9G9	26S proteasome non-ATPase regulatory subunit 7.	Proteasome subunit beta.	0.994
APZ42_004212	APZ42_014562	A0A164H788	A0A0N8D5W6	26S proteasome non-ATPase regulatory subunit 7.	26S proteasome non-ATPase regulatory subunit 9.	0.891
APZ42_004212	APZ42_014756	A0A164H788	A0A162PLG2	26S proteasome non-ATPase regulatory subunit 7.	Regulatory particle triple-A ATPase 6-related protein; Belongs to the AAA ATPase family.	0.999
APZ42_004212	APZ42_014874	A0A164H788	A0A0P5X5X2	26S proteasome non-ATPase regulatory subunit 7.	Proteasome inhibitor PI31 subunit.	0.591
APZ42_004212	APZ42_015341	A0A164H788	A0A162PED7	26S proteasome non-ATPase regulatory subunit 7.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.998
APZ42_004212	APZ42_016295	A0A164H788	A0A0P5G816	26S proteasome non-ATPase regulatory subunit 7.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.999
APZ42_004212	APZ42_016769	A0A164H788	A0A165A4X0	26S proteasome non-ATPase regulatory subunit 7.	S-phase kinase-associated protein.	0.751
APZ42_004212	APZ42_017595	A0A164H788	A0A164ZZ39	26S proteasome non-ATPase regulatory subunit 7.	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.	0.999
APZ42_004212	APZ42_017914	A0A164H788	A0A164ZF56	26S proteasome non-ATPase regulatory subunit 7.	Cullin-5; Belongs to the cullin family.	0.834
APZ42_004212	APZ42_017923	A0A164H788	A0A0N8DWI8	26S proteasome non-ATPase regulatory subunit 7.	Proteasome subunit beta.	0.999
APZ42_004212	APZ42_017932	A0A164H788	A0A162CIU5	26S proteasome non-ATPase regulatory subunit 7.	26S proteasome non-ATPase regulatory subunit 5.	0.993
APZ42_004212	APZ42_019436	A0A164H788	A0A0P6EFC2	26S proteasome non-ATPase regulatory subunit 7.	26S Protease regulatory subunit 4; Belongs to the AAA ATPase family.	0.999
APZ42_004212	APZ42_020152	A0A164H788	A0A0P5Z6A1	26S proteasome non-ATPase regulatory subunit 7.	26S proteasome non-ATPase regulatory subunit 11B.	0.999
APZ42_004212	APZ42_021386	A0A164H788	A0A0P5IS80	26S proteasome non-ATPase regulatory subunit 7.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.998
APZ42_004212	APZ42_021635	A0A164H788	A0A0P5V4U2	26S proteasome non-ATPase regulatory subunit 7.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.999
APZ42_004212	APZ42_021729	A0A164H788	A0A164WHS6	26S proteasome non-ATPase regulatory subunit 7.	Polyubiquitin-B.	0.956
APZ42_004212	APZ42_022784	A0A164H788	A0A0P6D0I8	26S proteasome non-ATPase regulatory subunit 7.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.998
APZ42_004212	APZ42_023256	A0A164H788	A0A164V3I3	26S proteasome non-ATPase regulatory subunit 7.	Putative G1/S-specific cyclin-D3; Belongs to the cyclin family.	0.581