(36 nodes) Ubiquinone and other terpenoid-quinone biosynthesis network (Daphnia magna)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	APZ42_025858	Uncharacterized protein. (493 aa)
	APZ42_025453	4-coumarate--CoA ligase 3. (500 aa)
	APZ42_025443	4-coumarate--CoA ligase 3-like protein. (837 aa)
	APZ42_023621	Cell division cycle and apoptosis regulator protein 1. (1009 aa)
	APZ42_019962	4-coumarate--CoA ligase 3. (594 aa)
	APZ42_019077	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (355 aa)
	APZ42_016261	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (276 aa)
	APZ42_019143	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (456 aa)
	EOG090X094T	UbiA prenyltransferase domain-containing protein 1. (326 aa)
	APZ42_011353	4-hydroxyphenylpyruvate dioxygenase-like protein. (411 aa)
	APZ42_011967	Acyl-CoA synthetase family member 2, mitochondrial. (532 aa)
	APZ42_025038	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner. (201 aa)
	APZ42_028075	Long-chain fatty acid transport protein 1. (541 aa)
	APZ42_014242	Alpha/beta hydrolase domain-containing protein. (320 aa)
	APZ42_030052	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (462 aa)
	APZ42_011358	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (275 aa)
	APZ42_019828	Vitamin K epoxide reductase complex subunit 1 protein 1. (287 aa)
	APZ42_011354	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (270 aa)
	APZ42_020018	Abhydrolase domain-containing protein. (481 aa)
	APZ42_030526	Acyl-coenzyme A thioesterase 13. (143 aa)
	APZ42_025441	Long-chain fatty acid transport protein 1. (594 aa)
	APZ42_022728	4-hydroxyphenylpyruvate dioxygenase. (383 aa)
	APZ42_005318	Putative Acyl-CoA synthetase family member. (124 aa)
	APZ42_015124	Uncharacterized protein. (503 aa)
	APZ42_014462	4-coumarate--CoA ligase 3. (219 aa)
	APZ42_011966	Luciferin 4-monooxygenase. (536 aa)
	APZ42_011817	4-hydroxyphenylpyruvate dioxygenase-like protein. (379 aa)
	APZ42_002833	Uncharacterized protein. (143 aa)
	APZ42_002784	Uncharacterized protein. (115 aa)
	APZ42_002290	4-coumarate--CoA ligase 3. (203 aa)
	APZ42_033014	Putative 4-coumarate--CoA ligase 3. (399 aa)
	APZ42_033021	Long-chain fatty acid transport protein 4. (518 aa)
	APZ42_032861	Mediator of RNA polymerase II transcription subunit 24. (986 aa)
	APZ42_030072	Putative 4-coumarate--CoA ligase 3. (274 aa)
	APZ42_028746	Gamma-glutamyl carboxylase. (686 aa)
	APZ42_027270	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (248 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_002290	APZ42_011353	A0A164IDD2	A0A0P6A487	4-coumarate--CoA ligase 3.	4-hydroxyphenylpyruvate dioxygenase-like protein.	0.511
APZ42_002290	APZ42_011354	A0A164IDD2	A0A0P5DWE1	4-coumarate--CoA ligase 3.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.523
APZ42_002290	APZ42_011358	A0A164IDD2	A0A0P4WW03	4-coumarate--CoA ligase 3.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.523
APZ42_002290	APZ42_011817	A0A164IDD2	A0A162T0K0	4-coumarate--CoA ligase 3.	4-hydroxyphenylpyruvate dioxygenase-like protein.	0.511
APZ42_002290	APZ42_014242	A0A164IDD2	A0A0N8AG56	4-coumarate--CoA ligase 3.	Alpha/beta hydrolase domain-containing protein.	0.428
APZ42_002290	APZ42_019143	A0A164IDD2	A0A162CP91	4-coumarate--CoA ligase 3.	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.	0.545
APZ42_002290	APZ42_020018	A0A164IDD2	A0A0P5KRB3	4-coumarate--CoA ligase 3.	Abhydrolase domain-containing protein.	0.428
APZ42_002290	APZ42_022728	A0A164IDD2	A0A0P5XAL6	4-coumarate--CoA ligase 3.	4-hydroxyphenylpyruvate dioxygenase.	0.511
APZ42_002290	APZ42_030052	A0A164IDD2	A0A0N8DCG0	4-coumarate--CoA ligase 3.	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.515
APZ42_002290	APZ42_033014	A0A164IDD2	A0A164LGB0	4-coumarate--CoA ligase 3.	Putative 4-coumarate--CoA ligase 3.	0.946
APZ42_002784	APZ42_011354	A0A164I1L9	A0A0P5DWE1	Uncharacterized protein.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.543
APZ42_002784	APZ42_011358	A0A164I1L9	A0A0P4WW03	Uncharacterized protein.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.543
APZ42_002784	APZ42_016261	A0A164I1L9	A0A165AIM5	Uncharacterized protein.	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).	0.511
APZ42_002784	APZ42_019077	A0A164I1L9	A0A164YN61	Uncharacterized protein.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.851
APZ42_002784	APZ42_019828	A0A164I1L9	A0A0P5AC32	Uncharacterized protein.	Vitamin K epoxide reductase complex subunit 1 protein 1.	0.647
APZ42_002784	APZ42_023621	A0A164I1L9	A0A164UVE8	Uncharacterized protein.	Cell division cycle and apoptosis regulator protein 1.	0.739
APZ42_002784	APZ42_025038	A0A164I1L9	A0A0P5ZIC3	Uncharacterized protein.	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner.	0.872
APZ42_002784	APZ42_030052	A0A164I1L9	A0A0N8DCG0	Uncharacterized protein.	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.876
APZ42_002784	EOG090X094T	A0A164I1L9	A0A0P6F4K9	Uncharacterized protein.	UbiA prenyltransferase domain-containing protein 1.	0.794
APZ42_002833	APZ42_011354	A0A164I0E7	A0A0P5DWE1	Uncharacterized protein.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.416