(49 nodes) Propanoate metabolism network (Daphnia magna)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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Your Input:
	APZ42_024537	4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (496 aa)
	APZ42_024491	Propionyl-CoA carboxylase beta chain, mitochondrial. (535 aa)
	APZ42_011187	VOC domain-containing protein. (156 aa)
	APZ42_034123	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (691 aa)
	APZ42_002221	Dihydrolipoamide dehydrogenase-like protein. (160 aa)
	APZ42_034440	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. (317 aa)
	APZ42_029379	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial. (525 aa)
	APZ42_022188	Protein-histidine N-methyltransferase. (498 aa)
	APZ42_026191	Methylmalonyl-CoA mutase, mitochondrial. (745 aa)
	APZ42_028207	3-hydroxypropionyl-Coenzyme A dehydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (300 aa)
	APZ42_026541	4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (497 aa)
	APZ42_017796	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (450 aa)
	APZ42_003276	Ornithine aminotransferase-like protein. (249 aa)
	APZ42_002820	Putative Folylpolyglutamate synthase. (121 aa)
	APZ42_002763	2-oxoisovalerate dehydrogenase subunit beta. (75 aa)
	APZ42_002597	Uncharacterized protein. (104 aa)
	APZ42_002591	Putative 2-oxoisovalerate dehydrogenase subunit beta. (142 aa)
	APZ42_002400	Putative Acetyl-Coenzyme A synthetase. (210 aa)
	APZ42_002190	Putative Aldehyde dehydrogenase. (160 aa)
	APZ42_002157	METMALONYL_COA_MUTASE domain-containing protein. (173 aa)
	APZ42_001998	Putative Trifunctional enzyme subunit alpha. (108 aa)
	APZ42_001925	Putative Lambda-crystallin. (169 aa)
	APZ42_001854	Dihydrolipoamide dehydrogenase-like protein. (117 aa)
	APZ42_034079	Putative U5 small nuclear ribonucleoprotein 200 kDa helicase. (2128 aa)
	APZ42_032855	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
	APZ42_032856	Acetyl-coenzyme A synthetase 2, mitochondrial-like protein. (687 aa)
	APZ42_028115	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (423 aa)
	APZ42_024864	L-lactate dehydrogenase. (638 aa)
	APZ42_024553	4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (539 aa)
	APZ42_023865	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (528 aa)
	APZ42_022926	Dihydrolipoyl dehydrogenase. (501 aa)
	APZ42_020915	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (433 aa)
	APZ42_016751	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (672 aa)
	APZ42_017008	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (659 aa)
	APZ42_016294	Acetyl-coenzyme A synthetase. (630 aa)
	Ldh	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (333 aa)
	APZ42_012355	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial. (716 aa)
	APZ42_022622	Acetyl-CoA acetyltransferase, cytosolic; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	APZ42_012378	Acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family. (501 aa)
	APZ42_017016	Malonyl-CoA decarboxylase, mitochondrial. (581 aa)
	APZ42_022248	Uncharacterized protein. (150 aa)
	APZ42_018401	Acetyl-coenzyme A synthetase. (652 aa)
	APZ42_002194	Sucb-like protein. (137 aa)
	APZ42_011144	Trifunctional enzyme subunit alpha. (658 aa)
	APZ42_015807	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (350 aa)
	APZ42_012084	Acetyl-CoA carboxylase. (1798 aa)
	APZ42_012087	Acetyl-CoA carboxylase. (417 aa)
	APZ42_011176	SET domain-containing protein 4. (414 aa)
	APZ42_017383	Enoyl-CoA hydratase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (295 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_001854	APZ42_002194	A0A164IPI5	A0A162CZ63	Dihydrolipoamide dehydrogenase-like protein.	Sucb-like protein.	0.755
APZ42_001854	APZ42_002221	A0A164IPI5	A0A162CZ45	Dihydrolipoamide dehydrogenase-like protein.	Dihydrolipoamide dehydrogenase-like protein.	0.946
APZ42_001854	APZ42_002400	A0A164IPI5	A0A164IAC2	Dihydrolipoamide dehydrogenase-like protein.	Putative Acetyl-Coenzyme A synthetase.	0.454
APZ42_001854	APZ42_002591	A0A164IPI5	A0A164I684	Dihydrolipoamide dehydrogenase-like protein.	Putative 2-oxoisovalerate dehydrogenase subunit beta.	0.904
APZ42_001854	APZ42_002763	A0A164IPI5	A0A164I223	Dihydrolipoamide dehydrogenase-like protein.	2-oxoisovalerate dehydrogenase subunit beta.	0.912
APZ42_001854	APZ42_003276	A0A164IPI5	A0A164HNE6	Dihydrolipoamide dehydrogenase-like protein.	Ornithine aminotransferase-like protein.	0.526
APZ42_001854	APZ42_016294	A0A164IPI5	A0A165ACK3	Dihydrolipoamide dehydrogenase-like protein.	Acetyl-coenzyme A synthetase.	0.454
APZ42_001854	APZ42_016751	A0A164IPI5	A0A165A5H7	Dihydrolipoamide dehydrogenase-like protein.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.562
APZ42_001854	APZ42_017008	A0A164IPI5	A0A165AAN5	Dihydrolipoamide dehydrogenase-like protein.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.562
APZ42_001854	APZ42_017796	A0A164IPI5	A0A0P6GYC3	Dihydrolipoamide dehydrogenase-like protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.944
APZ42_001854	APZ42_018401	A0A164IPI5	A0A0P6GZT6	Dihydrolipoamide dehydrogenase-like protein.	Acetyl-coenzyme A synthetase.	0.454
APZ42_001854	APZ42_020915	A0A164IPI5	A0A164X3T2	Dihydrolipoamide dehydrogenase-like protein.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.968
APZ42_001854	APZ42_023865	A0A164IPI5	A0A164U8W8	Dihydrolipoamide dehydrogenase-like protein.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.975
APZ42_001854	APZ42_024537	A0A164IPI5	A0A0N8CZN7	Dihydrolipoamide dehydrogenase-like protein.	4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.525
APZ42_001854	APZ42_024553	A0A164IPI5	A0A164TYQ6	Dihydrolipoamide dehydrogenase-like protein.	4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.525
APZ42_001854	APZ42_024864	A0A164IPI5	A0A164TLL4	Dihydrolipoamide dehydrogenase-like protein.	L-lactate dehydrogenase.	0.416
APZ42_001854	APZ42_026541	A0A164IPI5	A0A0P6CX18	Dihydrolipoamide dehydrogenase-like protein.	4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.525
APZ42_001854	APZ42_028115	A0A164IPI5	A0A164QUM9	Dihydrolipoamide dehydrogenase-like protein.	Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.755
APZ42_001854	APZ42_032855	A0A164IPI5	A0A164LZ80	Dihydrolipoamide dehydrogenase-like protein.	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.416
APZ42_001854	APZ42_032856	A0A164IPI5	A0A164LZA0	Dihydrolipoamide dehydrogenase-like protein.	Acetyl-coenzyme A synthetase 2, mitochondrial-like protein.	0.454