(40 nodes) Notch signaling pathway network (Daphnia magna)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APZ42_001722	Putative Presenilin. (124 aa)
	APZ42_020180	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (392 aa)
	APZ42_020321	Putative Corepressor interacting with RBPJ 1. (409 aa)
	APZ42_011336	C-terminal-binding protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (475 aa)
	APZ42_026807	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (434 aa)
	APZ42_026768	Puff-specific protein Bx42. (544 aa)
	APZ42_019025	Gamma-secretase subunit PEN-2. (101 aa)
	APZ42_026609	Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe. (378 aa)
	APZ42_023831	Gamma-secretase subunit Aph-1b. (340 aa)
	APZ42_022973	Adhesion G protein-coupled receptor E2; Belongs to the G-protein coupled receptor 2 family. (1667 aa)
	APZ42_016559	Hairless. (452 aa)
	APZ42_012709	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (540 aa)
	APZ42_031773	Neurogenic protein mastermind. (1345 aa)
	APZ42_001657	Groucho-like protein. (88 aa)
	APZ42_000788	Putative Recombining binding protein suppressor of hairless. (118 aa)
	APZ42_032936	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (646 aa)
	APZ42_029283	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (366 aa)
	APZ42_029061	Class E basic helix-loop-helix 40-like protein. (367 aa)
	APZ42_027338	Putative CREB-binding protein. (2063 aa)
	APZ42_027025	CREB-binding-like protein. (545 aa)
	APZ42_026767	Nicastrin. (700 aa)
	APZ42_026815	Class E basic helix-loop-helix 41-like protein. (753 aa)
	APZ42_023336	Recombining binding protein suppressor of hairless. (577 aa)
	APZ42_022064	Delta-like protein. (797 aa)
	APZ42_020740	Histone acetyltransferase KAT2A. (745 aa)
	APZ42_020324	Putative Transcription factor HES-2. (590 aa)
	APZ42_016321	Deltex protein. (238 aa)
	APZ42_019459	Hairy enhancer of split-like 1. (235 aa)
	APZ42_027527	Neurogenic locus notch protein. (2566 aa)
	APZ42_027608	Protein numb. (531 aa)
	APZ42_022562	Nucleosome-remodeling factor subunit NURF301. (2231 aa)
	APZ42_020665	Hairy/enhancer-of-split related with YRPW motif protein. (350 aa)
	APZ42_022790	Uncharacterized protein. (1061 aa)
	APZ42_020642	Groucho-like protein. (622 aa)
	APZ42_026322	Putative Segment polarity protein dishevelled. (699 aa)
	APZ42_030306	Groucho-like protein. (665 aa)
	APZ42_025136	Delta-like protein. (148 aa)
	APZ42_015383	ZP domain-containing protein. (456 aa)
	APZ42_013015	ADAM 17 Protease. (750 aa)
	APZ42_002704	Recombining binding protein suppressor of hairless. (127 aa)

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_000788	APZ42_001657	A0A164JDM5	A0A164IUD9	Putative Recombining binding protein suppressor of hairless.	Groucho-like protein.	0.659
APZ42_000788	APZ42_011336	A0A164JDM5	A0A0P5E3C9	Putative Recombining binding protein suppressor of hairless.	C-terminal-binding protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.874
APZ42_000788	APZ42_012709	A0A164JDM5	A0A0P5V584	Putative Recombining binding protein suppressor of hairless.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.873
APZ42_000788	APZ42_016559	A0A164JDM5	A0A0P5TGR3	Putative Recombining binding protein suppressor of hairless.	Hairless.	0.945
APZ42_000788	APZ42_019459	A0A164JDM5	H6UQP2	Putative Recombining binding protein suppressor of hairless.	Hairy enhancer of split-like 1.	0.602
APZ42_000788	APZ42_020180	A0A164JDM5	A0A0P4XN91	Putative Recombining binding protein suppressor of hairless.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.677
APZ42_000788	APZ42_020321	A0A164JDM5	A0A0P5DRM4	Putative Recombining binding protein suppressor of hairless.	Putative Corepressor interacting with RBPJ 1.	0.760
APZ42_000788	APZ42_020324	A0A164JDM5	A0A164XLU9	Putative Recombining binding protein suppressor of hairless.	Putative Transcription factor HES-2.	0.602
APZ42_000788	APZ42_020642	A0A164JDM5	A0A162CC84	Putative Recombining binding protein suppressor of hairless.	Groucho-like protein.	0.808
APZ42_000788	APZ42_020665	A0A164JDM5	A0A0P6A3E5	Putative Recombining binding protein suppressor of hairless.	Hairy/enhancer-of-split related with YRPW motif protein.	0.497
APZ42_000788	APZ42_020740	A0A164JDM5	A0A164XD17	Putative Recombining binding protein suppressor of hairless.	Histone acetyltransferase KAT2A.	0.881
APZ42_000788	APZ42_022064	A0A164JDM5	A0A164W012	Putative Recombining binding protein suppressor of hairless.	Delta-like protein.	0.828
APZ42_000788	APZ42_022790	A0A164JDM5	A0A162C899	Putative Recombining binding protein suppressor of hairless.	Uncharacterized protein.	0.784
APZ42_000788	APZ42_022973	A0A164JDM5	A0A0P5TGJ2	Putative Recombining binding protein suppressor of hairless.	Adhesion G protein-coupled receptor E2; Belongs to the G-protein coupled receptor 2 family.	0.828
APZ42_000788	APZ42_025136	A0A164JDM5	A0A162DDU3	Putative Recombining binding protein suppressor of hairless.	Delta-like protein.	0.716
APZ42_000788	APZ42_026768	A0A164JDM5	A0A0P5IWP5	Putative Recombining binding protein suppressor of hairless.	Puff-specific protein Bx42.	0.806
APZ42_000788	APZ42_026807	A0A164JDM5	A0A0P5EVU3	Putative Recombining binding protein suppressor of hairless.	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	0.677
APZ42_000788	APZ42_026815	A0A164JDM5	A0A164RZC3	Putative Recombining binding protein suppressor of hairless.	Class E basic helix-loop-helix 41-like protein.	0.413
APZ42_000788	APZ42_027025	A0A164JDM5	A0A164RS38	Putative Recombining binding protein suppressor of hairless.	CREB-binding-like protein.	0.612
APZ42_000788	APZ42_027338	A0A164JDM5	A0A164RHI9	Putative Recombining binding protein suppressor of hairless.	Putative CREB-binding protein.	0.784