STRINGSTRING
dnaN dnaN Aocu_00440 Aocu_00440 Aocu_00450 Aocu_00450 uvrA uvrA Aocu_01930 Aocu_01930 Aocu_02060 Aocu_02060 Aocu_02220 Aocu_02220 Aocu_04420 Aocu_04420 uvrB uvrB ssb1 ssb1 mutL mutL mutS mutS recA recA dnaQ dnaQ holA holA Aocu_10430 Aocu_10430 dnaI dnaI dnaB1 dnaB1 coaE coaE polA polA topA topA uvrC uvrC polC polC dnaE dnaE dnaB2 dnaB2 ssb2 ssb2 holB holB dnaX dnaX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaNDNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (376 aa)
Aocu_00440ATP-dependent DNA helicase, UvrD/REP type. (695 aa)
Aocu_00450ATP-dependent DNA helicase UvrD/REP type. (382 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (943 aa)
Aocu_01930ATP-dependent DNA helicase, RecQ-family. (1601 aa)
Aocu_02060DNA helicase. (902 aa)
Aocu_02220ATP-dependent DNA helicase. (712 aa)
Aocu_04420Excinuclease UvrABC system, truncated subunit B. (91 aa)
uvrBExcinuclease UvrABC system, subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits [...] (651 aa)
ssb1Single-stranded DNA-binding protein Ssb. (115 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (572 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (844 aa)
recARecombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (330 aa)
dnaQDNA polymerase III subunit epsilon. (222 aa)
holADNA polymerase III delta subunit. (315 aa)
Aocu_10430Calcineurin-like phosphoesterase. (229 aa)
dnaIPrisomal protein DnaI. (265 aa)
dnaB1Replication initiation and membrane attachment protein DnaB. (396 aa)
coaEDephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the FPG family. (455 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (881 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (595 aa)
uvrCUvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (577 aa)
polCDNA polymerase III alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1503 aa)
dnaEDNA polymerase III, alpha subunit. (978 aa)
dnaB2Replicative DNA helicase DnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (449 aa)
ssb2Single-stranded DNA-binding protein Ssb; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (142 aa)
holBDNA polymerase III, delta prime subunit. (315 aa)
dnaXDNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (561 aa)
Your Current Organism:
Acholeplasma oculi
NCBI taxonomy Id: 35623
Other names: A. oculi, ATCC 27350, Acholeplasma oculusi, NCTC 10150
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