STRINGSTRING
hprT hprT pgi pgi Aocu_00710 Aocu_00710 trpB trpB pdhA pdhA pdhB pdhB aceF aceF lpd lpd Aocu_01420 Aocu_01420 Aocu_01560 Aocu_01560 pheA pheA ldh ldh Aocu_02520 Aocu_02520 ctrI ctrI Aocu_02610 Aocu_02610 pgk pgk tpiA tpiA Aocu_03110 Aocu_03110 gapA gapA ilvE ilvE uppS uppS cdsA cdsA alkH alkH Aocu_03660 Aocu_03660 pfkA1 pfkA1 pfkA2 pfkA2 pykF pykF gndA gndA zwf zwf Aocu_05200 Aocu_05200 proC proC sdaA sdaA accE accE accG accG accD accD accA accA fabD fabD fabG1 fabG1 purB purB fadI fadI fabG2 fabG2 malP malP glgB glgB malS malS plsY plsY Aocu_06950 Aocu_06950 malQ malQ nplT nplT Aocu_07300 Aocu_07300 pulA pulA Aocu_07370 Aocu_07370 glgA glgA glgC glgC hemN hemN ansA ansA plsC plsC deoD deoD surE surE gph gph Aocu_07840 Aocu_07840 bglX bglX asnB asnB metK1 metK1 dapH dapH dapB dapB dapA dapA asd asd dapF dapF thrA thrA lysA lysA Aocu_09020 Aocu_09020 fni fni mvaK mvaK mvaD mvaD mvk mvk ribF ribF galU galU pgm pgm gpsA gpsA aroQ aroQ aroK aroK miaA miaA eno eno gpmI gpmI gcvT gcvT gcvH gcvH gcvP1 gcvP1 gcvP2 gcvP2 metK2 metK2 galM1 galM1 galM2 galM2 Aocu_12000 Aocu_12000 rpe rpe adhE2 adhE2 acpP acpP pgl pgl plsX plsX hmgS hmgS mvaA mvaA aroC aroC aroD aroD aroA aroA aroB aroB tyrA tyrA aroF aroF rpiB rpiB adk adk tkt tkt hepS hepS glyA glyA nifS nifS prs prs fba fba
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hprTHypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (423 aa)
Aocu_00710Terpenoid synthase; Belongs to the FPP/GGPP synthase family. (284 aa)
trpBTryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (391 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit subgroup x; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (361 aa)
pdhBPyruvate dehydrogenase (acetyl-transferring) E1 component, beta subunit. (327 aa)
aceFDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (538 aa)
lpdDihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. (458 aa)
Aocu_01420Glycosyl hydrolase, family 32; Belongs to the glycosyl hydrolase 32 family. (467 aa)
Aocu_01560Glycoside hydrolase, family 32; Belongs to the glycosyl hydrolase 32 family. (506 aa)
pheAPrephenate dehydratase. (269 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (315 aa)
Aocu_02520Tocopherol cyclase. (319 aa)
ctrIPhytoene desaturase. (495 aa)
Aocu_02610Squalene/Phytoene synthase. (288 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa)
Aocu_03110Sphingosine kinase. (280 aa)
gapANAD-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (337 aa)
ilvEBranched-chain amino acid aminotransferase. (328 aa)
uppSUndecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (223 aa)
cdsAPhosphatidate cytidylyltransferase; Belongs to the CDS family. (319 aa)
alkHAldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (432 aa)
Aocu_03660Kinase, PfkB-family; Belongs to the carbohydrate kinase PfkB family. (306 aa)
pfkA16-Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (414 aa)
pfkA26-Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (316 aa)
pykFPyruvate kinase; Belongs to the pyruvate kinase family. (450 aa)
gndA6-phosphogluconate dehydrogenase, decarboxylating. (299 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (447 aa)
Aocu_05200Antibiotic biosynthesis monooxygenase. (104 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (266 aa)
sdaAL-serine dehydratase. (403 aa)
accEBiotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (148 aa)
accGBiotin carboxylase of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (459 aa)
accDAcetyl-coenzyme A carboxyl transferase, beta chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (293 aa)
accAAcetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (270 aa)
fabDMalonyl CoA-acyl carrier protein transacylase. (307 aa)
fabG13-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa)
purBAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (432 aa)
fadI3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
fabG23-oxoacyl-[acyl-carrier-protein] reductase. (240 aa)
malPGlycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (791 aa)
glgBGlycogen (1,4-alpha-glucan) branching enzyme. (615 aa)
malSAlpha amylase; Belongs to the glycosyl hydrolase 13 family. (658 aa)
plsYGlycerol-3-phosphate acyltransferase PlsY; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (227 aa)
Aocu_06950Predicted lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis. (255 aa)
malQPutative 4-alpha-glucanotransferase. (489 aa)
nplTPutative Neopullulanase. (598 aa)
Aocu_07300Alpha-amylase. (427 aa)
pulAPullulanase, type I; Belongs to the glycosyl hydrolase 13 family. (988 aa)
Aocu_07370Alpha amylase. (514 aa)
glgAGlycogen synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (473 aa)
glgCGlucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (408 aa)
hemNOxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (363 aa)
ansAL-Asparaginase. (326 aa)
plsC1-Acyl-sn-glycerol-3-phosphate acyltransferase. (261 aa)
deoDPurine nucleoside phosphorylase. (236 aa)
surE5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (245 aa)
gphPhosphoglycolate phosphatase. (218 aa)
Aocu_07840Glycoside hydrolase family 3 protein. (615 aa)
bglXBeta-glucosidase. (1025 aa)
asnBAsparagine synthetase (glutamine-hydrolyzing). (524 aa)
metK1S-Adenosylmethionine synthetase; Belongs to the AdoMet synthase family. (371 aa)
dapH2,3,4,5-Tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (236 aa)
dapB4-Hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (241 aa)
dapA4-Hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (289 aa)
asdAspartate-semialdehyde dehydrogenase, beta-type; Belongs to the aspartate-semialdehyde dehydrogenase family. (330 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (260 aa)
thrAAspartate kinase, monofunctional class; Belongs to the aspartokinase family. (400 aa)
lysADiaminopimelate decarboxylase LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (418 aa)
Aocu_090205'-Nucleotidase; Belongs to the 5'-nucleotidase family. (572 aa)
fniIsopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (324 aa)
mvaKPhosphomevalonate kinase. (347 aa)
mvaDDiphosphomevalonate decarboxylase. (315 aa)
mvkMevalonate kinase. (313 aa)
ribFRiboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. (300 aa)
galUUTP--glucose-1-phosphate uridylyltransferase. (286 aa)
pgmPhosphoglucomutase. (543 aa)
gpsANAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (331 aa)
aroQ3-Dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (142 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (163 aa)
miaAtRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (280 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa)
gcvTGlycine cleavage system T protein. (356 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (122 aa)
gcvP1Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (437 aa)
gcvP2Glycine cleavage system P protein, subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (481 aa)
metK2S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (386 aa)
galM1Aldose 1-epimerase. (301 aa)
galM2Aldose 1-epimerase. (319 aa)
Aocu_12000FAD-linked oxidase. (465 aa)
rpeRibulose-5-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (210 aa)
adhE2Bifunctional aldehyde/alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (862 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa)
pgl6-phosphogluconolactonase. (307 aa)
plsXPhosphate acyltransferase PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (334 aa)
hmgSHydroxymethylglutaryl-CoA synthase. (381 aa)
mvaAHydroxymethylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family. (408 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (328 aa)
aroDShikimate 5-dehydrogenase I alpha. (259 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (413 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (332 aa)
tyrAPrephenate dehydrogenase. (276 aa)
aroF3-deoxy-7-phosphoheptulonate synthase. (340 aa)
rpiBRibose 5-phosphate isomerase B. (148 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
tktTransketolase; Belongs to the transketolase family. (651 aa)
hepSHeptaprenyl diphosphate synthase component I. (171 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (411 aa)
nifSPyridoxal phosphate-dependent transferase. (396 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (322 aa)
fbaFructose-1,6-bisphosphate aldolase, class II. (287 aa)
Your Current Organism:
Acholeplasma oculi
NCBI taxonomy Id: 35623
Other names: A. oculi, ATCC 27350, Acholeplasma oculusi, NCTC 10150
Server load: low (12%) [HD]