STRINGSTRING
acsA acsA AFU46967.1 AFU46967.1 accA accA AFU46999.1 AFU46999.1 gshA gshA AFU47218.1 AFU47218.1 dxs dxs cysM cysM AFU47488.1 AFU47488.1 bioD bioD bioF bioF metE metE AFU47546.1 AFU47546.1 AFU47630.1 AFU47630.1 AFU46210.1 AFU46210.1 AFU47667.1 AFU47667.1 AFU47722.1 AFU47722.1 AFU47764.1 AFU47764.1 bioB bioB AFU48008.1 AFU48008.1 AFU48099.1 AFU48099.1 AFU48111.1 AFU48111.1 thiL thiL gshB gshB AFU48207.1 AFU48207.1 AFU48266.1 AFU48266.1 AFU48419.1 AFU48419.1 AFU48321.1 AFU48321.1 metX metX prpE prpE folD folD AFU45738.1 AFU45738.1 AFU45736.1 AFU45736.1 AFU45734.1 AFU45734.1 AFU45730.1 AFU45730.1 AFU45728.1 AFU45728.1 thiG thiG AFU45726.1 AFU45726.1 AFU45653.1 AFU45653.1 AFU45399.1 AFU45399.1 AFU45369.1 AFU45369.1 AFU45257.1 AFU45257.1 AFU45217.1 AFU45217.1 asd asd accD accD AFU45183.1 AFU45183.1 AFU44787.1 AFU44787.1 AFU44771.1 AFU44771.1 metK metK thiC thiC AFU44438.1 AFU44438.1 AFU44362.1 AFU44362.1 AFU44254.1 AFU44254.1 lipA lipA AFU43941.1 AFU43941.1 AFU43882.1 AFU43882.1 AFU46274.1 AFU46274.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (664 aa)
AFU46967.1Hypothetical protein. (83 aa)
accAacetyl-CoA carboxylase, carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa)
AFU46999.1Methionine gamma-lyase; COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases. (430 aa)
gshAGlutamate--cysteine ligase; COG2918 Gamma-glutamylcysteine synthetase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (508 aa)
AFU47218.1COG1045 Serine acetyltransferase. (260 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (631 aa)
cysMCOG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (300 aa)
AFU47488.1Aminotransferase; COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (441 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (223 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (406 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (797 aa)
AFU47546.1Biotin synthesis protein BioC; COG0500 SAM-dependent methyltransferases. (300 aa)
AFU47630.1COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (319 aa)
AFU46210.1COG3435 Gentisate 1,2-dioxygenase. (377 aa)
AFU47667.1acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa)
AFU47722.1benzoate-CoA ligase family protein; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (517 aa)
AFU47764.1COG0685 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (283 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (347 aa)
AFU48008.1COG0405 Gamma-glutamyltransferase. (653 aa)
AFU48099.1COG0405 Gamma-glutamyltransferase. (533 aa)
AFU48111.1Hypothetical protein. (199 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (324 aa)
gshBCOG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase); Belongs to the prokaryotic GSH synthase family. (318 aa)
AFU48207.15'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (250 aa)
AFU48266.13-demethylubiquinone-9 3-methyltransferase; COG2764 Uncharacterized protein conserved in bacteria. (142 aa)
AFU48419.1Beta alanine--pyruvate transaminase; COG0161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (453 aa)
AFU48321.1Hypothetical protein. (177 aa)
metXHomoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (376 aa)
prpECOG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (633 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
AFU45738.1COG0155 Sulfite reductase, beta subunit (hemoprotein). (612 aa)
AFU45736.1COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes. (209 aa)
AFU45734.1COG2895 GTPases - Sulfate adenylate transferase subunit 1. (457 aa)
AFU45730.1COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (284 aa)
AFU45728.1COG2104 Sulfur transfer protein involved in thiamine biosynthesis. (65 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (269 aa)
AFU45726.1Thiamine-phosphate pyrophosphorylase; COG0352 Thiamine monophosphate synthase. (298 aa)
AFU45653.1Putative phosphoadenosine phosphosulfate reductase. (242 aa)
AFU45399.1Hypothetical protein. (320 aa)
AFU45369.1COG0405 Gamma-glutamyltransferase. (615 aa)
AFU45257.1Pyridoxal-5'-phosphate-dependent enzyme subunit beta; COG0031 Cysteine synthase. (358 aa)
AFU45217.1COG0460 Homoserine dehydrogenase. (444 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (376 aa)
accDacetyl-CoA carboxylase, carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa)
AFU45183.1COG0110 Acetyltransferase (isoleucine patch superfamily). (195 aa)
AFU44787.1COG0405 Gamma-glutamyltransferase. (595 aa)
AFU44771.1Hypothetical protein; COG2021 Homoserine acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (355 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (393 aa)
thiCPhosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (634 aa)
AFU44438.1COG0031 Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (305 aa)
AFU44362.1Hypothetical protein; COG0439 Biotin carboxylase. (370 aa)
AFU44254.12-aminobenzoate-CoA ligase; COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (555 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (326 aa)
AFU43941.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (913 aa)
AFU43882.1COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases. (699 aa)
AFU46274.1Mta/sah nucleosidase; COG0775 Nucleoside phosphorylase. (303 aa)
Your Current Organism:
Acidovorax sp. KKS102
NCBI taxonomy Id: 358220
Other names: A. sp. KKS102
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