STRINGSTRING
APW99299.1 APW99299.1 purK purK purE purE purA purA carB carB APW99488.1 APW99488.1 udk udk guaAA guaAA APW99297.1 APW99297.1 purD purD adk adk purL purL pyrF pyrF purM purM guaB guaB pyrB pyrB APW98248.1 APW98248.1 purF purF APW97951.1 APW97951.1 pyrE pyrE ribK ribK APW97565.1 APW97565.1 APW97410.1 APW97410.1 upp upp prs prs APW97117.1 APW97117.1 purO purO APW96899.1 APW96899.1 purC purC APW96545.1 APW96545.1 purS purS purQ purQ APW96470.1 APW96470.1 APW96450.1 APW96450.1 APW96449.1 APW96449.1 carA carA guaAB guaAB APW96346.1 APW96346.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APW99299.1Dihydroorotate dehydrogenase (quinone); Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (385 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (215 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (459 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1057 aa)
APW99488.1Guanosine monophosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (361 aa)
udkUridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
guaAAGMP synthase; Catalyzes the synthesis of GMP from XMP. (184 aa)
APW99297.1Allantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (449 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (211 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (718 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (265 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (500 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
APW98248.1Orotate phosphoribosyltransferase-like protein; Purine/pyrimidine phosphoribosyltransferase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (490 aa)
APW97951.1Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (178 aa)
ribKRiboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (235 aa)
APW97565.1methionyl-tRNA formyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (304 aa)
APW97410.1Formyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (225 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (287 aa)
APW97117.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
purOIMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. (198 aa)
APW96899.1Dihydroorotase; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (341 aa)
APW96545.1Formyltetrahydrofolate deformylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (83 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (224 aa)
APW96470.1Biotin transporter BioY; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
APW96450.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (461 aa)
APW96449.1Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (542 aa)
carACarbamoyl-phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (358 aa)
guaABGMP synthase; Catalyzes the synthesis of GMP from XMP. (305 aa)
APW96346.1Phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
Your Current Organism:
Halobiforma lacisalsi
NCBI taxonomy Id: 358396
Other names: H. lacisalsi AJ5, Halobiforma lacisalsi AJ5, Halobiforma lacisalsi str. AJ5, Halobiforma lacisalsi strain AJ5
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.