STRINGSTRING
APW98852.1 APW98852.1 pyrF pyrF APW98783.1 APW98783.1 purM purM guaB guaB APW98543.1 APW98543.1 purE purE purA purA APW99856.1 APW99856.1 APW99763.1 APW99763.1 APW99754.1 APW99754.1 APW99728.1 APW99728.1 APW99696.1 APW99696.1 APW99671.1 APW99671.1 APW99669.1 APW99669.1 pyrG pyrG APW96372.1 APW96372.1 APW96346.1 APW96346.1 mfnA mfnA APW99732.1 APW99732.1 APW97951.1 APW97951.1 APW98060.1 APW98060.1 APW98062.1 APW98062.1 purF purF panB panB APW98248.1 APW98248.1 ndk ndk pyrB pyrB APW96470.1 APW96470.1 APW96450.1 APW96450.1 APW96449.1 APW96449.1 carA carA guaAB guaAB APW99644.1 APW99644.1 APW99589.1 APW99589.1 carB carB APW99488.1 APW99488.1 udk udk guaAA guaAA APW99299.1 APW99299.1 APW99297.1 APW99297.1 purD purD purS purS APW96545.1 APW96545.1 purC purC APW96657.1 APW96657.1 APW96899.1 APW96899.1 APW96983.1 APW96983.1 purO purO APW97117.1 APW97117.1 upp upp APW97339.1 APW97339.1 APW97410.1 APW97410.1 atpD atpD atpB atpB atpA atpA atpF atpF atpC atpC atpE atpE APW97554.1 APW97554.1 APW97565.1 APW97565.1 pyrH pyrH APW97647.1 APW97647.1 APW97786.1 APW97786.1 ribK ribK pyrE pyrE purQ purQ purK purK APW99176.1 APW99176.1 adk adk APW99099.1 APW99099.1 purL purL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APW98852.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (545 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (265 aa)
APW98783.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (500 aa)
APW98543.1Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (156 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (215 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (459 aa)
APW99856.1DNA/pantothenate metabolism flavoprotein; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
APW99763.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
APW99754.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
APW99728.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
APW99696.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
APW99671.1Acetyl-coenzyme A synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (658 aa)
APW99669.1acetate--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (662 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (563 aa)
APW96372.1acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (672 aa)
APW96346.1Phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
mfnATyrosine decarboxylase MfnA; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (381 aa)
APW99732.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
APW97951.1Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
APW98060.1Sugar kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
APW98062.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (490 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (270 aa)
APW98248.1Orotate phosphoribosyltransferase-like protein; Purine/pyrimidine phosphoribosyltransferase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (154 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
APW96470.1Biotin transporter BioY; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
APW96450.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (461 aa)
APW96449.1Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (542 aa)
carACarbamoyl-phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (358 aa)
guaABGMP synthase; Catalyzes the synthesis of GMP from XMP. (305 aa)
APW99644.1Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
APW99589.1ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1057 aa)
APW99488.1Guanosine monophosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (361 aa)
udkUridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
guaAAGMP synthase; Catalyzes the synthesis of GMP from XMP. (184 aa)
APW99299.1Dihydroorotate dehydrogenase (quinone); Derived by automated computational analysis using gene prediction method: Protein Homology. (358 aa)
APW99297.1Allantoinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (449 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (83 aa)
APW96545.1Formyltetrahydrofolate deformylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (341 aa)
APW96657.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
APW96899.1Dihydroorotase; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
APW96983.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (307 aa)
purOIMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. (198 aa)
APW97117.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (225 aa)
APW97339.1Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (369 aa)
APW97410.1Formyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
atpDV-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (250 aa)
atpBATP synthase archaeal, B subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (476 aa)
atpAATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (587 aa)
atpFV-type ATP synthase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane. (111 aa)
atpCATP synthase A1 subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane. (366 aa)
atpEV-type ATP synthase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (195 aa)
APW97554.1Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (212 aa)
APW97565.1methionyl-tRNA formyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (304 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (248 aa)
APW97647.1acetate--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (658 aa)
APW97786.1acyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
ribKRiboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (235 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (178 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (224 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (385 aa)
APW99176.1acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (559 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (211 aa)
APW99099.1Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (718 aa)
Your Current Organism:
Halobiforma lacisalsi
NCBI taxonomy Id: 358396
Other names: H. lacisalsi AJ5, Halobiforma lacisalsi AJ5, Halobiforma lacisalsi str. AJ5, Halobiforma lacisalsi strain AJ5
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