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fabH fabH FabF FabF dhaS3 dhaS3 adh adh AcnA AcnA B4167_0499 B4167_0499 mqo mqo B4167_0634 B4167_0634 B4167_0706 B4167_0706 mce mce ackA ackA B4167_0749 B4167_0749 accD accD accA accA B4167_0759 B4167_0759 B4167_0760 B4167_0760 mdh mdh B4167_0806 B4167_0806 B4167_0807 B4167_0807 sdhB sdhB B4167_0887 B4167_0887 B4167_0892 B4167_0892 B4167_1015 B4167_1015 B4167_1089 B4167_1089 B4167_1090 B4167_1090 B4167_1129 B4167_1129 B4167_1146 B4167_1146 pckA pckA ilvE3 ilvE3 ycsA ycsA Pta Pta lipL lipL icmF icmF ilvC ilvC ilvH ilvH ilvB ilvB leuA leuA leuB leuB leuC leuC leuD leuD B4167_1672 B4167_1672 odhA odhA B4167_1715 B4167_1715 lipM lipM lipA lipA B4167_1839 B4167_1839 B4167_1914 B4167_1914 B4167_1929 B4167_1929 B4167_1932 B4167_1932 B4167_1933 B4167_1933 GabD GabD B4167_2195 B4167_2195 acoB acoB B4167_2197 B4167_2197 LpdA LpdA ldh ldh B4167_2321 B4167_2321 fumC fumC ykwC ykwC pdhA pdhA pdhB pdhB B4167_2451 B4167_2451 LpdA-2 LpdA-2 Pyc Pyc B4167_2656 B4167_2656 fabZ fabZ B4167_2824 B4167_2824 B4167_2956 B4167_2956 fabL fabL ilvD ilvD B4167_3303 B4167_3303 fabD fabD fabG3 fabG3 sucC sucC sucD sucD B4167_3481 B4167_3481 aceA aceA B4167_3644 B4167_3644 B4167_3687 B4167_3687 B4167_3691 B4167_3691 fabI fabI B4167_3765 B4167_3765 B4167_3766 B4167_3766 B4167_3767 B4167_3767 B4167_3768 B4167_3768 bfmBAB bfmBAB bfmBAA bfmBAA bfmBC bfmBC ldh1 ldh1 accC1 accC1 AccB AccB B4167_3802 B4167_3802 PflA PflA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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fabH3-oxoacyl-[acyl-carrier-protein] synthase, KASIII; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (310 aa)
FabF3-oxoacyl-[acyl-carrier-protein] synthase, KASII; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (412 aa)
dhaS3Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (497 aa)
adhAlcohol dehydrogenase. (343 aa)
AcnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (909 aa)
B4167_0499Hypothetical protein; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases, YtcI -like protein. (527 aa)
mqoMalate:quinone oxidoreductase. (513 aa)
B4167_0634NAD-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (425 aa)
B4167_0706Acetyl-coenzyme A carboxyl transferase alpha chain. (517 aa)
mceMethylmalonyl-CoA epimerase. (133 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa)
B4167_0749NADP-dependent malic enzyme. (409 aa)
accDAcetyl-coenzyme A carboxyl transferase beta chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (287 aa)
accAAcetyl-coenzyme A carboxyl transferase alpha chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (318 aa)
B4167_0759Citrate synthase (si); Belongs to the citrate synthase family. (371 aa)
B4167_0760Isocitrate dehydrogenase [NADP]. (424 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (310 aa)
B4167_0806Hypothetical protein; Succinate dehydrogenase cytochrome b558 subunit. (203 aa)
B4167_0807Succinate dehydrogenase flavoprotein subunit. (583 aa)
sdhBSuccinate dehydrogenase iron-sulfur protein. (255 aa)
B4167_0887Alcohol dehydrogenase. (400 aa)
B4167_0892Alcohol dehydrogenase; Acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (868 aa)
B4167_1015Membrane protein, putative. (409 aa)
B4167_1089Pyruvate,phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (887 aa)
B4167_1090Hypothetical protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (283 aa)
B4167_1129NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (459 aa)
B4167_1146Acetyl-coenzyme A synthetase. (571 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (528 aa)
ilvE3Branched-chain amino acid aminotransferase. (358 aa)
ycsATartrate dehydrogenase / Tartrate decarboxylase / D-malic enzyme. (362 aa)
PtaPhosphate acetyltransferase. (323 aa)
lipLHypothetical protein; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. (279 aa)
icmFB12 binding domain; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1092 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (343 aa)
ilvHAcetolactate synthase small subunit. (171 aa)
ilvBAcetolactate synthase large subunit. (575 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (364 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (195 aa)
B4167_1672Dihydrolipoamide succinyltransferase component (E2); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (423 aa)
odhA2-oxoglutarate dehydrogenase E1 component; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (956 aa)
B4167_1715Aliphatic amidase amiE. (258 aa)
lipMLipoate-protein ligase A. (282 aa)
lipAHypothetical protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (311 aa)
B4167_18396-aminohexanoate-cyclic-dimer hydrolase; Belongs to the amidase family. (496 aa)
B4167_1914Hypothetical protein; acetyl-CoA hydrolase/transferase family protein. (504 aa)
B4167_1929Methylcrotonyl-CoA carboxylase carboxyl transferase subunit. (509 aa)
B4167_1932Biotin carboxyl carrier protein of methylcrotonyl-CoA carboxylase. (70 aa)
B4167_1933Biotin carboxylase of methylcrotonyl-CoA carboxylase. (454 aa)
GabDSuccinate-semialdehyde dehydrogenase [NADP+]; Belongs to the aldehyde dehydrogenase family. (482 aa)
B4167_2195Hypothetical protein; Dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex. (414 aa)
acoBHypothetical protein; Acetoin dehydrogenase E1 component beta-subunit. (345 aa)
B4167_2197Hypothetical protein; Acetoin dehydrogenase E1 component alpha-subunit. (318 aa)
LpdADihydrolipoamide dehydrogenase of acetoin dehydrogenase. (450 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (316 aa)
B4167_2321Lipoate-protein ligase A. (331 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)
ykwC2-hydroxy-3-oxopropionate reductase. (291 aa)
pdhAPyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (371 aa)
pdhBPyruvate dehydrogenase E1 component beta subunit. (325 aa)
B4167_2451Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (535 aa)
LpdA-2Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. (470 aa)
PycPyruvate carboxyl transferase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1143 aa)
B4167_2656Alcohol dehydrogenase. (330 aa)
fabZHypothetical protein; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (140 aa)
B4167_2824Hypothetical protein; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases, YtcI -like protein. (524 aa)
B4167_2956Putative Acylphosphate phosphohydrolase. (90 aa)
fabLEnoyl-[acyl-carrier-protein] reductase [NADPH]. (249 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (559 aa)
B4167_3303Hypothetical protein. (251 aa)
fabDMalonyl CoA-acyl carrier protein transacylase. (315 aa)
fabG33-oxoacyl-[acyl-carrier protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa)
sucCSuccinyl-CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (387 aa)
sucDSuccinyl-CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
B4167_3481Malate synthase; Belongs to the malate synthase family. (525 aa)
aceAIsocitrate lyase. (425 aa)
B4167_3644FIG00673147: hypothetical protein. (430 aa)
B4167_3687Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (494 aa)
B4167_3691Hypothetical protein; Glycolate oxidase, subunit GlcD, putative. (458 aa)
fabIEnoyl-[acyl-carrier-protein] reductase [NADH]. (259 aa)
B4167_3765Putative periplasmic protein kinase ArgK and related GTPases of G3E family. (340 aa)
B4167_3766Methylmalonyl-CoA mutase. (731 aa)
B4167_3767Methylmalonyl-CoA mutase. (645 aa)
B4167_3768Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (417 aa)
bfmBABBranched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit. (327 aa)
bfmBAABranched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit. (330 aa)
bfmBCDihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase. (472 aa)
ldh1Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (366 aa)
accC1Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (452 aa)
AccBHypothetical protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (172 aa)
B4167_3802Pyruvate formate-lyase. (743 aa)
PflAPyruvate formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (247 aa)
Your Current Organism:
Bacillus thermoamylovorans
NCBI taxonomy Id: 35841
Other names: B. thermoamylovorans, Bacillus sp. LMG 18084, Bacillus sp. R-6546, Bacillus sp. R-7440, Bacillus sp. R-7764, LMG 18084, LMG:18084, Lactobacter thermoamylovorans, strain DKP
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