STRINGSTRING
AcnA AcnA mqo mqo B4167_0634 B4167_0634 B4167_0749 B4167_0749 B4167_0759 B4167_0759 B4167_0760 B4167_0760 mdh mdh B4167_0806 B4167_0806 B4167_0807 B4167_0807 sdhB sdhB B4167_1129 B4167_1129 pckA pckA lipL lipL B4167_1672 B4167_1672 odhA odhA B4167_1715 B4167_1715 lipM lipM lipA lipA GabD GabD B4167_2195 B4167_2195 acoB acoB B4167_2197 B4167_2197 LpdA LpdA B4167_2321 B4167_2321 fumC fumC pdhA pdhA pdhB pdhB B4167_2451 B4167_2451 LpdA-2 LpdA-2 sucC sucC sucD sucD B4167_3644 B4167_3644 B4167_3768 B4167_3768 bfmBAB bfmBAB bfmBAA bfmBAA bfmBC bfmBC ldh1 ldh1
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
AcnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (909 aa)
mqoMalate:quinone oxidoreductase. (513 aa)
B4167_0634NAD-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (425 aa)
B4167_0749NADP-dependent malic enzyme. (409 aa)
B4167_0759Citrate synthase (si); Belongs to the citrate synthase family. (371 aa)
B4167_0760Isocitrate dehydrogenase [NADP]. (424 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (310 aa)
B4167_0806Hypothetical protein; Succinate dehydrogenase cytochrome b558 subunit. (203 aa)
B4167_0807Succinate dehydrogenase flavoprotein subunit. (583 aa)
sdhBSuccinate dehydrogenase iron-sulfur protein. (255 aa)
B4167_1129NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (459 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (528 aa)
lipLHypothetical protein; Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes; Belongs to the octanoyltransferase LipL family. (279 aa)
B4167_1672Dihydrolipoamide succinyltransferase component (E2); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (423 aa)
odhA2-oxoglutarate dehydrogenase E1 component; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (956 aa)
B4167_1715Aliphatic amidase amiE. (258 aa)
lipMLipoate-protein ligase A. (282 aa)
lipAHypothetical protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (311 aa)
GabDSuccinate-semialdehyde dehydrogenase [NADP+]; Belongs to the aldehyde dehydrogenase family. (482 aa)
B4167_2195Hypothetical protein; Dihydrolipoamide acetyltransferase component (E2) of acetoin dehydrogenase complex. (414 aa)
acoBHypothetical protein; Acetoin dehydrogenase E1 component beta-subunit. (345 aa)
B4167_2197Hypothetical protein; Acetoin dehydrogenase E1 component alpha-subunit. (318 aa)
LpdADihydrolipoamide dehydrogenase of acetoin dehydrogenase. (450 aa)
B4167_2321Lipoate-protein ligase A. (331 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (462 aa)
pdhAPyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (371 aa)
pdhBPyruvate dehydrogenase E1 component beta subunit. (325 aa)
B4167_2451Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (535 aa)
LpdA-2Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. (470 aa)
sucCSuccinyl-CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (387 aa)
sucDSuccinyl-CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
B4167_3644FIG00673147: hypothetical protein. (430 aa)
B4167_3768Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (417 aa)
bfmBABBranched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit. (327 aa)
bfmBAABranched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit. (330 aa)
bfmBCDihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase. (472 aa)
ldh1Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (366 aa)
Your Current Organism:
Bacillus thermoamylovorans
NCBI taxonomy Id: 35841
Other names: B. thermoamylovorans, Bacillus sp. LMG 18084, Bacillus sp. R-6546, Bacillus sp. R-7440, Bacillus sp. R-7764, LMG 18084, LMG:18084, Lactobacter thermoamylovorans, strain DKP
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