(33 nodes) Valine, leucine and isoleucine degradation network (Bacillus thermoamylovorans)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	B4167_0223	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
	dhaS3	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (497 aa)
	B4167_0394	Butyryl-CoA dehydrogenase. (379 aa)
	B4167_0395	Butyryl-CoA dehydrogenase. (400 aa)
	B4167_0398	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (377 aa)
	B4167_0471	Acyl-CoA dehydrogenase. (402 aa)
	B4167_0706	Acetyl-coenzyme A carboxyl transferase alpha chain. (517 aa)
	mce	Methylmalonyl-CoA epimerase. (133 aa)
	B4167_1158	Acyl-CoA dehydrogenase. (401 aa)
	B4167_1162	Butyryl-CoA dehydrogenase. (391 aa)
	B4167_1163	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	ilvE3	Branched-chain amino acid aminotransferase. (358 aa)
	thlA	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
	B4167_1239	Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A. (237 aa)
	B4167_1256	Acyl-CoA dehydrogenase. (559 aa)
	B4167_1289	3-ketoacyl-CoA thiolase [isoleucine degradation]; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
	B4167_1292	Butyryl-CoA dehydrogenase. (377 aa)
	fadA3	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (383 aa)
	B4167_1686	Butyryl-CoA dehydrogenase. (380 aa)
	B4167_1931	Hydroxymethylglutaryl-CoA lyase. (311 aa)
	LpdA	Dihydrolipoamide dehydrogenase of acetoin dehydrogenase. (450 aa)
	ykwC	2-hydroxy-3-oxopropionate reductase. (291 aa)
	LpdA-2	Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. (470 aa)
	B4167_2551	3-hydroxybutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase /. (299 aa)
	B4167_3539	Acetoacetyl-CoA synthetase. (659 aa)
	B4167_3687	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (494 aa)
	B4167_3766	Methylmalonyl-CoA mutase. (731 aa)
	B4167_3767	Methylmalonyl-CoA mutase. (645 aa)
	B4167_3768	Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex. (417 aa)
	bfmBAB	Branched-chain alpha-keto acid dehydrogenase, E1 component, beta subunit. (327 aa)
	bfmBAA	Branched-chain alpha-keto acid dehydrogenase, E1 component, alpha subunit. (330 aa)
	bfmBC	Dihydrolipoamide dehydrogenase of branched-chain alpha-keto acid dehydrogenase. (472 aa)
	ldh1	Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (366 aa)

Your Current Organism:

Bacillus thermoamylovorans

NCBI taxonomy Id: 35841
Other names: B. thermoamylovorans, Bacillus sp. LMG 18084, Bacillus sp. R-6546, Bacillus sp. R-7440, Bacillus sp. R-7764, LMG 18084, LMG:18084, Lactobacter thermoamylovorans, strain DKP

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B4167_0223	B4167_0394	B4167_0223	B4167_0394	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Butyryl-CoA dehydrogenase.	0.796
B4167_0223	B4167_0395	B4167_0223	B4167_0395	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Butyryl-CoA dehydrogenase.	0.796
B4167_0223	B4167_0398	B4167_0223	B4167_0398	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.909
B4167_0223	B4167_0471	B4167_0223	B4167_0471	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA dehydrogenase.	0.813
B4167_0223	B4167_0706	B4167_0223	B4167_0706	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-coenzyme A carboxyl transferase alpha chain.	0.937
B4167_0223	B4167_1158	B4167_0223	B4167_1158	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA dehydrogenase.	0.813
B4167_0223	B4167_1162	B4167_0223	B4167_1162	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Butyryl-CoA dehydrogenase.	0.810
B4167_0223	B4167_1163	B4167_0223	B4167_1163	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.905
B4167_0223	B4167_1239	B4167_0223	B4167_1239	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A.	0.847
B4167_0223	B4167_1256	B4167_0223	B4167_1256	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acyl-CoA dehydrogenase.	0.824
B4167_0223	B4167_1289	B4167_0223	B4167_1289	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase [isoleucine degradation]; Belongs to the thiolase-like superfamily. Thiolase family.	0.914
B4167_0223	B4167_1292	B4167_0223	B4167_1292	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Butyryl-CoA dehydrogenase.	0.950
B4167_0223	B4167_1686	B4167_0223	B4167_1686	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Butyryl-CoA dehydrogenase.	0.810
B4167_0223	B4167_1931	B4167_0223	B4167_1931	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Hydroxymethylglutaryl-CoA lyase.	0.930
B4167_0223	B4167_2551	B4167_0223	B4167_2551	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-hydroxybutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase /.	0.973
B4167_0223	B4167_3768	B4167_0223	B4167_3768	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Dihydrolipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex.	0.820
B4167_0223	fadA3	B4167_0223	B4167_1685	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.909
B4167_0223	thlA	B4167_0223	B4167_1232	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.910
B4167_0394	B4167_0223	B4167_0394	B4167_0223	Butyryl-CoA dehydrogenase.	3-ketoacyl-CoA thiolase / Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.796
B4167_0394	B4167_0395	B4167_0394	B4167_0395	Butyryl-CoA dehydrogenase.	Butyryl-CoA dehydrogenase.	0.950

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