STRINGSTRING
tmk tmk BAH41348.1 BAH41348.1 psuG psuG BAH41634.1 BAH41634.1 BAH41914.1 BAH41914.1 BAH42362.1 BAH42362.1 BAH42589.1 BAH42589.1 ushA ushA BAH42837.1 BAH42837.1 udk udk cdd cdd dck dck punA punA pdp pdp cmk cmk ndk ndk dut dut deoD deoD nrdF nrdF nrdE nrdE BAH44147.1 BAH44147.1 pydC pydC pydB pydB BAH44214.1 BAH44214.1 gltB gltB pyrH pyrH pyrE pyrE pyrF pyrF pyrAB pyrAB pyrAA pyrAA pyrC pyrC pyrB pyrB pyrR pyrR surE surE BAH45043.1 BAH45043.1 BAH45221.1 BAH45221.1 tysY tysY yunD yunD pyrD pyrD carB carB carA carA upp upp tdk tdk pyrG pyrG BAH46543.1 BAH46543.1 BAH46650.1 BAH46650.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (213 aa)
BAH41348.1Conserved hypothetical protein; Belongs to the carbohydrate kinase PfkB family. (362 aa)
psuGConserved hypothetical protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (308 aa)
BAH41634.1Hypothetical protein. (191 aa)
BAH41914.1Conserved hypothetical protein. (234 aa)
BAH42362.1Conserved hypothetical protein. (753 aa)
BAH42589.1Conserved hypothetical protein. (297 aa)
ushAProbable 5'-nucleotidase precursor; Belongs to the 5'-nucleotidase family. (625 aa)
BAH42837.1Probable 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Belongs to the 5'-nucleotidase family. (662 aa)
udkUridine kinase. (214 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (132 aa)
dckDeoxyadenosine/deoxycytidine kinase. (230 aa)
punAPurine nucleoside phosphorylase I; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (269 aa)
pdpProbable pyrimidine-nucleoside phosphorylase. (435 aa)
cmkCytidylate kinase. (223 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (147 aa)
dutPutative deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (176 aa)
deoDPurine nucleoside phosphorylase II. (235 aa)
nrdFRibonucleoside-diphosphate reductase beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (316 aa)
nrdERibonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (694 aa)
BAH44147.1Conserved hypothetical protein. (381 aa)
pydCBeta-alanine synthase. (296 aa)
pydBDihydropyrimidinase. (461 aa)
BAH44214.1Conserved hypothetical protein. (425 aa)
gltBProbable glutamate synthase small chain. (448 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (240 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (209 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (245 aa)
pyrABCarbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1070 aa)
pyrAACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (365 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (426 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (313 aa)
pyrRPyrimidine operon regulatory protein/uracil phosphoribosyltransferase; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (179 aa)
surEPutative nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (265 aa)
BAH45043.1Conserved hypothetical protein. (317 aa)
BAH45221.1Conserved hypothetical protein. (319 aa)
tysYThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
yunDPutative nucleotidase; Belongs to the 5'-nucleotidase family. (484 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (363 aa)
carBArginine-specific carbamoyl-phosphate synthase large chain. (1080 aa)
carAArginine-specific carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (368 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
tdkThymidine kinase. (191 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (531 aa)
BAH46543.1Putative purine nucleoside phosphorylase. (240 aa)
BAH46650.1Putative 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor; Belongs to the 5'-nucleotidase family. (662 aa)
Your Current Organism:
Brevibacillus brevis
NCBI taxonomy Id: 358681
Other names: B. brevis NBRC 100599, Brevibacillus brevis NBRC 100599, Brevibacillus brevis str. NBRC 100599, Brevibacillus brevis strain NBRC 100599
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