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citA citA BAH41992.1 BAH41992.1 citZ citZ icd icd ilvE ilvE ilvB ilvB ilvH ilvH ilvC ilvC leuA leuA leuB leuB lysC lysC argE argE leuD leuD leuC leuC dapG dapG asd asd dapC dapC BAH45160.1 BAH45160.1 acoN acoN BAH45211.1 BAH45211.1 ilvD ilvD BAH45347.1 BAH45347.1 BAH45359.1 BAH45359.1 yclM yclM argD argD argB argB argC argC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
citACitrate synthase; Belongs to the citrate synthase family. (367 aa)
BAH41992.1Probable 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). Belongs to the alpha-IPM synthase/homocitrate synthase family. (514 aa)
citZCitrate synthase; Belongs to the citrate synthase family. (370 aa)
icdIsocitrate dehydrogenase [NADP]. (427 aa)
ilvEBranched-chain amino acid aminotransferase. (357 aa)
ilvBAcetolactate synthase large subunit. (574 aa)
ilvHAcetolactate synthase small subunit. (168 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (512 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (364 aa)
lysCAspartokinase 2; Belongs to the aspartokinase family. (413 aa)
argEPutative acetylornithine deacetylase. (426 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (194 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (476 aa)
dapGAspartokinase 1; Belongs to the aspartokinase family. (408 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (346 aa)
dapCPutative acetyldiaminopimelate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (404 aa)
BAH45160.1Putative aminotransferase. (402 aa)
acoNAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (909 aa)
BAH45211.1Probable peptidase M20A family protein. (395 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (558 aa)
BAH45347.1Putative acetyltransferase; Belongs to the acetyltransferase family. (157 aa)
BAH45359.12-isopropylmalate synthase/homocitrate synthase related family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (540 aa)
yclMAspartokinase 3; Belongs to the aspartokinase family. (467 aa)
argDAcetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (393 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (265 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa)
Your Current Organism:
Brevibacillus brevis
NCBI taxonomy Id: 358681
Other names: B. brevis NBRC 100599, Brevibacillus brevis NBRC 100599, Brevibacillus brevis str. NBRC 100599, Brevibacillus brevis strain NBRC 100599
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