STRINGSTRING
SFS23764.1 SFS23764.1 SFR94932.1 SFR94932.1 SFR95074.1 SFR95074.1 SFR83269.1 SFR83269.1 SFR95338.1 SFR95338.1 SFR95457.1 SFR95457.1 SFR96189.1 SFR96189.1 xseA xseA SFR96294.1 SFR96294.1 SFR96377.1 SFR96377.1 rnr rnr SFR96456.1 SFR96456.1 pth pth SFR85969.1 SFR85969.1 SFR86133.1 SFR86133.1 SFR86150.1 SFR86150.1 mutS2 mutS2 SFR83526.1 SFR83526.1 SFR87828.1 SFR87828.1 SFR88856.1 SFR88856.1 SFR89494.1 SFR89494.1 SFR89863.1 SFR89863.1 SFR91170.1 SFR91170.1 SFR91997.1 SFR91997.1 SFR92295.1 SFR92295.1 rny rny SFR92885.1 SFR92885.1 SFR92938.1 SFR92938.1 SFR93236.1 SFR93236.1 SFR93312.1 SFR93312.1 fbp fbp recJ recJ nth nth SFR94227.1 SFR94227.1 SFR94483.1 SFR94483.1 SFS02857.1 SFS02857.1 SFS03326.1 SFS03326.1 SFS03622.1 SFS03622.1 SFS03736.1 SFS03736.1 SFS03768.1 SFS03768.1 dtd dtd SFS03906.1 SFS03906.1 xth xth SFS04572.1 SFS04572.1 SFS05024.1 SFS05024.1 SFS05031.1 SFS05031.1 nth-2 nth-2 SFS06675.1 SFS06675.1 SFS00264.1 SFS00264.1 SFS10193.1 SFS10193.1 SFS09303.1 SFS09303.1 mrnC mrnC SFS11324.1 SFS11324.1 rnj rnj ruvX ruvX SFS12605.1 SFS12605.1 uvrA uvrA SFS13164.1 SFS13164.1 sbcD sbcD addA addA addB addB ybaK ybaK SFS15368.1 SFS15368.1 leuS leuS uvrC uvrC SFS15895.1 SFS15895.1 SFS16205.1 SFS16205.1 SFS16354.1 SFS16354.1 polC polC fbp-2 fbp-2 SFS17032.1 SFS17032.1 SFS14862.1 SFS14862.1 ileS ileS SFS18504.1 SFS18504.1 SFS18570.1 SFS18570.1 SFS18840.1 SFS18840.1 SFS19252.1 SFS19252.1 SFS19275.1 SFS19275.1 SFS18189.1 SFS18189.1 SFS19415.1 SFS19415.1 SFS20248.1 SFS20248.1 valS valS SFS20335.1 SFS20335.1 ybeY ybeY SFS20358.1 SFS20358.1 rnhB rnhB SFS20466.1 SFS20466.1 rnhA rnhA SFS20483.1 SFS20483.1 recU recU SFS20636.1 SFS20636.1 SFS20654.1 SFS20654.1 SFS20709.1 SFS20709.1 SFS20022.1 SFS20022.1 SFS20106.1 SFS20106.1 SFS21445.1 SFS21445.1 SFS21539.1 SFS21539.1 SFS21583.1 SFS21583.1 SFS21604.1 SFS21604.1 SFS21645.1 SFS21645.1 SFS21649.1 SFS21649.1 SFS21844.1 SFS21844.1 SFS21946.1 SFS21946.1 SFS21187.1 SFS21187.1 uvrB uvrB SFS22501.1 SFS22501.1 SFS22123.1 SFS22123.1 SFS22074.1 SFS22074.1 SFS22174.1 SFS22174.1 SFS22239.1 SFS22239.1 rnc rnc SFS22713.1 SFS22713.1 SFS22723.1 SFS22723.1 SFS22918.1 SFS22918.1 SFS23111.1 SFS23111.1 rnz rnz SFS23161.1 SFS23161.1 SFS23188.1 SFS23188.1 SFS23285.1 SFS23285.1 SFS23295.1 SFS23295.1 SFS23337.1 SFS23337.1 SFS23342.1 SFS23342.1 SFS23381.1 SFS23381.1 SFS23426.1 SFS23426.1 cas5c cas5c cas4 cas4 cas1 cas1 cas2 cas2 SFS23445.1 SFS23445.1 SFS23446.1 SFS23446.1 SFS23455.1 SFS23455.1 SFS23457.1 SFS23457.1 nfo nfo SFS23510.1 SFS23510.1 SFS23482.1 SFS23482.1 rnpA rnpA SFS23694.1 SFS23694.1 nfo-2 nfo-2 SFS23723.1 SFS23723.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFS23764.1Hypothetical protein. (466 aa)
SFR94932.1Glycerophosphoryl diester phosphodiesterase. (243 aa)
SFR95074.1acyl-CoA thioesterase. (132 aa)
SFR83269.1Inhibitor of the KinA pathway to sporulation, predicted exonuclease. (323 aa)
SFR95338.1Protein-tyrosine phosphatase. (240 aa)
SFR95457.1Hypothetical protein. (125 aa)
SFR96189.1Lysophospholipase L1. (302 aa)
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (423 aa)
SFR96294.1Exodeoxyribonuclease VII small subunit. (77 aa)
SFR96377.1Hypothetical protein. (261 aa)
rnrRibonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (755 aa)
SFR96456.1Putative hydrolases of HD superfamily. (188 aa)
pthpeptidyl-tRNA hydrolase, PTH1 family; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (216 aa)
SFR85969.1TatD DNase family protein. (262 aa)
SFR86133.1Glycerophosphoryl diester phosphodiesterase. (244 aa)
SFR86150.1Hypothetical protein. (283 aa)
mutS2DNA mismatch repair protein MutS2; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (812 aa)
SFR83526.1Stage II sporulation protein E. (473 aa)
SFR87828.1Hypothetical protein. (269 aa)
SFR88856.1Hypothetical protein. (274 aa)
SFR89494.1D-alpha,beta-D-heptose 1,7-bisphosphate phosphatase. (192 aa)
SFR89863.1Hypothetical protein. (340 aa)
SFR91170.1alpha-L-rhamnosidase. (901 aa)
SFR91997.1mRNA interferase MazF; Toxic component of a type II toxin-antitoxin (TA) system. (138 aa)
SFR92295.1Protein-tyrosine phosphatase. (244 aa)
rnyRibonucrease Y; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. (516 aa)
SFR92885.1Putative hydrolase. (245 aa)
SFR92938.1Hypothetical protein. (290 aa)
SFR93236.1Lysophospholipase L1. (217 aa)
SFR93312.1Ribonuclease Z. (267 aa)
fbpFructose-1,6-bisphosphatase-3. (645 aa)
recJExonuclease RecJ. (579 aa)
nthEndonuclease-3; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (213 aa)
SFR94227.1MutS domain V; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity. Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (649 aa)
SFR94483.1Hypothetical protein. (144 aa)
SFS02857.1Hypothetical protein. (304 aa)
SFS03326.16-phosphogluconolactonase. (353 aa)
SFS03622.1Hypothetical protein. (340 aa)
SFS03736.1Putative hydrolase. (279 aa)
SFS03768.1Glycerophosphoryl diester phosphodiesterase. (600 aa)
dtdD-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (150 aa)
SFS03906.12-haloacid dehalogenase. (237 aa)
xthExodeoxyribonuclease-3. (251 aa)
SFS04572.1Uncharacterized protein. (304 aa)
SFS05024.16-phosphogluconolactonase. (323 aa)
SFS05031.1dGTPase. (468 aa)
nth-2DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (223 aa)
SFS06675.1DNA polymerase-3 subunit alpha. (240 aa)
SFS00264.12',3'-cyclic-nucleotide 2'-phosphodiesterase/5'-or 3'-nucleotidase, 5'-nucleotidase family; Belongs to the 5'-nucleotidase family. (609 aa)
SFS10193.1HDIG domain-containing protein. (198 aa)
SFS09303.16-phosphogluconolactonase. (363 aa)
mrnCRibonuclease-3 family protein; Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors; Belongs to the MrnC RNase family. (180 aa)
SFS11324.1Putative hydrolase. (240 aa)
rnjRibonuclease J; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (748 aa)
ruvXPutative holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (148 aa)
SFS12605.1Hypothetical protein. (275 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (949 aa)
SFS13164.1Exonuclease SbcC. (977 aa)
sbcDExodeoxyribonuclease I subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (407 aa)
addADNA helicase/exodeoxyribonuclease V, subunit A; ATP-dependent DNA helicase. (1257 aa)
addBDNA helicase/exodeoxyribonuclease V, subunit B; ATP-dependent DNA helicase. (1183 aa)
ybaKCys-tRNA(Pro)/Cys-tRNA(Cys) deacylase; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (155 aa)
SFS15368.1dGTPase; Belongs to the dGTPase family. Type 2 subfamily. (336 aa)
leuSleucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (804 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (624 aa)
SFS15895.1DNA polymerase III catalytic subunit, DnaE type. (1161 aa)
SFS16205.1Protein phosphatase. (248 aa)
SFS16354.1Sulfatase. (622 aa)
polCDNA polymerase III catalytic subunit, PolC type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1539 aa)
fbp-2Fructose-1,6-bisphosphatase-3. (656 aa)
SFS17032.1ACT domain-containing protein; Belongs to the UPF0237 family. (90 aa)
SFS14862.1Ala-tRNA(Pro) deacylase. (198 aa)
ileSIsoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1044 aa)
SFS18504.1Choline-sulfatase. (481 aa)
SFS18570.1Esterase PHB depolymerase. (600 aa)
SFS18840.1T/G mismatch-specific endonuclease. (145 aa)
SFS19252.1Hypothetical protein. (271 aa)
SFS19275.1Phosphonoacetate hydrolase. (377 aa)
SFS18189.1Hypothetical protein. (329 aa)
SFS19415.16-phosphogluconolactonase, cycloisomerase 2 family. (356 aa)
SFS20248.1Cys-tRNA(Pro) deacylase, prolyl-tRNA editing enzyme YbaK/EbsC. (162 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (880 aa)
SFS20335.1mRNA interferase MazF; Toxic component of a type II toxin-antitoxin (TA) system. (115 aa)
ybeYProbable rRNA maturation factor; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (165 aa)
SFS20358.1Stage V sporulation protein B. (566 aa)
rnhBRNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (219 aa)
SFS20466.1Metallo-beta-lactamase family protein. (535 aa)
rnhARibonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (160 aa)
SFS20483.1TIGR00255 family protein. (292 aa)
recURecombination protein U; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family. (177 aa)
SFS20636.1Hypothetical protein. (420 aa)
SFS20654.1Ribonuclease G. (401 aa)
SFS20709.1Putative two-component system response regulator. (978 aa)
SFS20022.1DNA polymerase-1. (356 aa)
SFS20106.1Lysophospholipase L1. (209 aa)
SFS21445.1Arylsulfatase A. (502 aa)
SFS21539.1Protein-tyrosine phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (152 aa)
SFS21583.1Histidinol-phosphatase (PHP family); Belongs to the PHP hydrolase family. HisK subfamily. (269 aa)
SFS21604.12',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase; Belongs to the 5'-nucleotidase family. (510 aa)
SFS21645.1Stage V sporulation protein B. (520 aa)
SFS21649.1Hypothetical protein. (265 aa)
SFS21844.1Putative two-component system response regulator. (1261 aa)
SFS21946.1Hypothetical protein. (328 aa)
SFS21187.1Myo-inositol-1(or 4)-monophosphatase. (257 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (660 aa)
SFS22501.1Acyl-ACP thioesterase. (246 aa)
SFS22123.1Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains. (623 aa)
SFS22074.1Diguanylate cyclase (GGDEF) domain-containing protein. (461 aa)
SFS22174.1Hypothetical protein. (168 aa)
SFS22239.1Uncharacterized conserved protein, LabA/DUF88 family. (312 aa)
rncRibonuclease-3; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (230 aa)
SFS22713.1Putative hydrolase of the HAD superfamily. (207 aa)
SFS22723.1Protein-tyrosine phosphatase. (239 aa)
SFS22918.1Hypothetical protein. (2306 aa)
SFS23111.1Hypothetical protein. (275 aa)
rnzRibonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (303 aa)
SFS23161.1Glycerophosphoryl diester phosphodiesterase. (292 aa)
SFS23188.1Putative hydrolase of the HAD superfamily. (212 aa)
SFS23285.1Stage II sporulation protein E (SpoIIE). (392 aa)
SFS23295.1acyl-CoA thioesterase. (133 aa)
SFS23337.1Choline-sulfatase. (483 aa)
SFS23342.1Triacylglycerol lipase. (465 aa)
SFS23381.12',3'-cyclic-nucleotide 2'-phosphodiesterase / 3'-nucleotidase; Belongs to the 5'-nucleotidase family. (617 aa)
SFS23426.1Hypothetical protein. (266 aa)
cas5cCRISPR-associated protein Cas5d. (219 aa)
cas4CRISPR-associated exonuclease, Cas4 family; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (211 aa)
cas1CRISP-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (350 aa)
cas2CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (96 aa)
SFS23445.15-methylcytosine-specific restriction enzyme B. (570 aa)
SFS23446.15-methylcytosine-specific restriction enzyme subunit McrC. (403 aa)
SFS23455.1Arylsulfatase A. (490 aa)
SFS23457.1Arylsulfatase A. (462 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (327 aa)
SFS23510.1Histidinol-phosphatase (PHP family); Belongs to the PHP hydrolase family. HisK subfamily. (262 aa)
SFS23482.1Ala-tRNA(Pro) deacylase. (82 aa)
rnpARibonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (114 aa)
SFS23694.1DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] (372 aa)
nfo-2Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (277 aa)
SFS23723.1Lactonase, 7-bladed beta-propeller. (303 aa)
Your Current Organism:
Clostridium citroniae
NCBI taxonomy Id: 358743
Other names: CCUG 52203, Clostridium citroniae Warren et al. 2007, DSM 19261, [. citroniae, [Clostridium] citroniae, strain RMA 16102
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