STRINGSTRING
SFS04701.1 SFS04701.1 SFS04376.1 SFS04376.1 clpB clpB SFS04098.1 SFS04098.1 SFS03804.1 SFS03804.1 cadA cadA SFR94310.1 SFR94310.1 SFR94227.1 SFR94227.1 recD2 recD2 ftsY ftsY SFS22676.1 SFS22676.1 SFS14643.1 SFS14643.1 hppA hppA SFS15557.1 SFS15557.1 scpB scpB SFS09650.1 SFS09650.1 hflX hflX addB addB addA addA ftsH-2 ftsH-2 uvrA uvrA guaA guaA SFS12842.1 SFS12842.1 era era ftsH ftsH SFS09180.1 SFS09180.1 ffh ffh smc smc mutL mutL minD minD ftsZ ftsZ prfC prfC uvrB uvrB SFS22308.1 SFS22308.1 SFS22293.1 SFS22293.1 SFS22571.1 SFS22571.1 ychF ychF htpG htpG SFS21201.1 SFS21201.1 SFS21016.1 SFS21016.1 SFS21112.1 SFS21112.1 SFS21081.1 SFS21081.1 infB infB lepA lepA hppA-2 hppA-2 SFS20062.1 SFS20062.1 SFS20044.1 SFS20044.1 obgE obgE hisI hisI recG recG spoIVA spoIVA SFS20455.1 SFS20455.1 SFS19927.1 SFS19927.1 typA typA lon lon clpX clpX SFS20213.1 SFS20213.1 SFS18400.1 SFS18400.1 SFS18290.1 SFS18290.1 SFS19491.1 SFS19491.1 pcrA pcrA SFS19081.1 SFS19081.1 SFS18891.1 SFS18891.1 SFS18590.1 SFS18590.1 SFS15060.1 SFS15060.1 SFS15045.1 SFS15045.1 selB selB kdpB kdpB SFS16748.1 SFS16748.1 SFS14719.1 SFS14719.1 SFS16255.1 SFS16255.1 rsgA rsgA SFS22882.1 SFS22882.1 mgtA mgtA rdgB rdgB SFR93219.1 SFR93219.1 SFR83890.1 SFR83890.1 SFR92271.1 SFR92271.1 SFR91279.1 SFR91279.1 tuf tuf fusA fusA SFR83713.1 SFR83713.1 SFR88350.1 SFR88350.1 hflB hflB mutS2 mutS2 SFR85460.1 SFR85460.1 SFR85222.1 SFR85222.1 maf maf uppP uppP SFR95186.1 SFR95186.1 SFR94915.1 SFR94915.1 SFS22778.1 SFS22778.1 clpX-2 clpX-2 SFS23362.1 SFS23362.1 ruvB ruvB ruvA ruvA SFS23356.1 SFS23356.1 SFS23445.1 SFS23445.1 SFS23679.1 SFS23679.1 SFS23681.1 SFS23681.1 mnmE mnmE SFS04716.1 SFS04716.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFS04701.1Ca2+-transporting ATPase. (869 aa)
SFS04376.1Exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase. (521 aa)
clpBATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (863 aa)
SFS04098.1Ca2+-transporting ATPase. (902 aa)
SFS03804.1ATPase family associated with various cellular activities (AAA). (516 aa)
cadACd2+/Zn2+-exporting ATPase. (621 aa)
SFR94310.1Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase. (233 aa)
SFR94227.1MutS domain V; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity. Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (649 aa)
recD2Exodeoxyribonuclease V alpha subunit; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (763 aa)
ftsYFused signal recognition particle receptor; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (312 aa)
SFS22676.1Putative membrane protein. (292 aa)
SFS14643.1Small GTP-binding protein domain-containing protein. (911 aa)
hppAK(+)-stimulated pyrophosphate-energized sodium pump; Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane. Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily. (660 aa)
SFS15557.1Translation elongation factor 2 (EF-2/EF-G). (698 aa)
scpBSegregation and condensation protein B; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (261 aa)
SFS09650.1Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (171 aa)
hflXGTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (422 aa)
addBDNA helicase/exodeoxyribonuclease V, subunit B; ATP-dependent DNA helicase. (1183 aa)
addADNA helicase/exodeoxyribonuclease V, subunit A; ATP-dependent DNA helicase. (1257 aa)
ftsH-2Cell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (622 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (949 aa)
guaAGMP synthase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. (513 aa)
SFS12842.1NTP pyrophosphatase, house-cleaning of non-canonical NTPs. (119 aa)
eraGTP-binding protein Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (303 aa)
ftsHCell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (715 aa)
SFS09180.1AAA domain-containing protein, putative AbiEii toxin, Type IV TA system. (425 aa)
ffhSignal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (458 aa)
smcCondensin subunit Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1186 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (679 aa)
minDSeptum site-determining protein MinD. (263 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (431 aa)
prfCPeptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (534 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (660 aa)
SFS22308.1DNA helicase-2 / ATP-dependent DNA helicase PcrA. (697 aa)
SFS22293.1Acylphosphatase. (88 aa)
SFS22571.1Hypothetical protein. (280 aa)
ychFHypothetical protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (365 aa)
htpGMolecular chaperone HtpG. (669 aa)
SFS21201.1EcsC protein family protein. (278 aa)
SFS21016.1DNA helicase-2 / ATP-dependent DNA helicase PcrA. (608 aa)
SFS21112.1HAD family hydrolase; Haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E. (217 aa)
SFS21081.1Phosphoglycolate phosphatase. (222 aa)
infBBacterial translation initiation factor 2 (bIF-2); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (1154 aa)
lepAGTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (604 aa)
hppA-2K(+)-stimulated pyrophosphate-energized sodium pump; Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane. Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily. (694 aa)
SFS20062.1Rad3-related DNA helicase. (818 aa)
SFS20044.1NUMOD1 domain-containing protein. (151 aa)
obgEGTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (429 aa)
hisIphosphoribosyl-ATP pyrophosphatase; In the C-terminal section; belongs to the PRA-PH family. (437 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (685 aa)
spoIVAStage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat. (491 aa)
SFS20455.1Hypothetical protein. (226 aa)
SFS19927.1ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. (850 aa)
typAGTP-binding protein. (609 aa)
lonATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (776 aa)
clpXATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (439 aa)
SFS20213.1CYTH domain-containing protein. (158 aa)
SFS18400.1ATPase, P-type (transporting), HAD superfamily, subfamily IC/heavy metal translocating P-type ATPase. (691 aa)
SFS18290.1Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (278 aa)
SFS19491.1Cu2+-exporting ATPase. (836 aa)
pcrADNA helicase-2 / ATP-dependent DNA helicase PcrA. (797 aa)
SFS19081.1Hypothetical protein. (431 aa)
SFS18891.1Ribosomal protection tetracycline resistance protein. (639 aa)
SFS18590.1ATP-dependent Lon protease. (494 aa)
SFS15060.1Phosphoglycolate phosphatase. (227 aa)
SFS15045.1Putative membrane protein. (270 aa)
selBSelenocysteine-specific elongation factor. (636 aa)
kdpBK+-transporting ATPase ATPase B chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (695 aa)
SFS16748.1Cu+-exporting ATPase. (786 aa)
SFS14719.1MoxR-like ATPase. (363 aa)
SFS16255.1Hypothetical protein. (148 aa)
rsgARibosome biogenesis GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (292 aa)
SFS22882.1Copper-(or silver)-translocating P-type ATPase. (635 aa)
mgtAMg2+-importing ATPase. (878 aa)
rdgBXTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (213 aa)
SFR93219.1MgsA AAA+ ATPase C terminal. (195 aa)
SFR83890.1Hypothetical protein. (674 aa)
SFR92271.1Hypothetical protein. (470 aa)
SFR91279.1Manganese-dependent inorganic pyrophosphatase. (556 aa)
tufElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (397 aa)
fusATranslation elongation factor 2 (EF-2/EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. [...] (705 aa)
SFR83713.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (452 aa)
SFR88350.1Putative ATPase. (439 aa)
hflBCell division protease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (604 aa)
mutS2DNA mismatch repair protein MutS2; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (812 aa)
SFR85460.1Chromosome partitioning protein. (256 aa)
SFR85222.1Flagellum-specific ATP synthase. (434 aa)
mafSeptum formation protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (204 aa)
uppPUndecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (280 aa)
SFR95186.1AAA domain (dynein-related subfamily). (306 aa)
SFR94915.1Recombination protein MgsA. (439 aa)
SFS22778.1Protein of unknown function. (157 aa)
clpX-2ATP-dependent Clp protease ATP-binding subunit ClpX. (476 aa)
SFS23362.1AAA domain-containing protein, putative AbiEii toxin, Type IV TA system. (487 aa)
ruvBHolliday junction DNA helicase subunit RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (330 aa)
ruvAHolliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (209 aa)
SFS23356.1Pyrophosphatase PpaX. (225 aa)
SFS23445.15-methylcytosine-specific restriction enzyme B. (570 aa)
SFS23679.1Protein of unknown function. (170 aa)
SFS23681.1Chromosome partitioning protein. (256 aa)
mnmEtRNA modification GTPase; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (459 aa)
SFS04716.1GMP synthase (glutamine-hydrolysing). (432 aa)
Your Current Organism:
Clostridium citroniae
NCBI taxonomy Id: 358743
Other names: CCUG 52203, Clostridium citroniae Warren et al. 2007, DSM 19261, [. citroniae, [Clostridium] citroniae, strain RMA 16102
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