STRINGSTRING
topA topA ruvA ruvA gyrB-2 gyrB-2 gyrA gyrA recQ recQ gyrB gyrB SFR83713.1 SFR83713.1 topB topB recD2 recD2 addA addA addB addB SFS15592.1 SFS15592.1 priA priA SFS16391.1 SFS16391.1 SFS16866.1 SFS16866.1 SFS16881.1 SFS16881.1 SFS18913.1 SFS18913.1 SFS18990.1 SFS18990.1 SFS19014.1 SFS19014.1 SFS19187.1 SFS19187.1 pcrA pcrA recG recG SFS20544.1 SFS20544.1 SFS20062.1 SFS20062.1 SFS20148.1 SFS20148.1 SFS21016.1 SFS21016.1 SFS22308.1 SFS22308.1 ruvB ruvB SFS16861.1 SFS16861.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (695 aa)
ruvAHolliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (209 aa)
gyrB-2DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (637 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (848 aa)
recQATP-dependent DNA helicase RecQ. (787 aa)
gyrBDNA gyrase subunit B. (655 aa)
SFR83713.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (452 aa)
topBDNA topoisomerase-3; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (735 aa)
recD2Exodeoxyribonuclease V alpha subunit; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (763 aa)
addADNA helicase/exodeoxyribonuclease V, subunit A; ATP-dependent DNA helicase. (1257 aa)
addBDNA helicase/exodeoxyribonuclease V, subunit B; ATP-dependent DNA helicase. (1183 aa)
SFS15592.1TIGR00375 family protein. (1070 aa)
priAReplication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (752 aa)
SFS16391.1Magnesium chelatase family protein. (513 aa)
SFS16866.1DNA gyrase subunit A. (744 aa)
SFS16881.1DNA topoisomerase-3. (705 aa)
SFS18913.1Relaxase/Mobilisation nuclease domain-containing protein. (541 aa)
SFS18990.1DNA topoisomerase-3. (696 aa)
SFS19014.1Type IV secretory pathway, VirD2 components (relaxase). (444 aa)
SFS19187.1Helicase conserved C-terminal domain-containing protein. (1233 aa)
pcrADNA helicase-2 / ATP-dependent DNA helicase PcrA. (797 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (685 aa)
SFS20544.1Small, acid-soluble spore protein, alpha/beta type. (67 aa)
SFS20062.1Rad3-related DNA helicase. (818 aa)
SFS20148.1Small, acid-soluble spore protein, alpha/beta type. (70 aa)
SFS21016.1DNA helicase-2 / ATP-dependent DNA helicase PcrA. (608 aa)
SFS22308.1DNA helicase-2 / ATP-dependent DNA helicase PcrA. (697 aa)
ruvBHolliday junction DNA helicase subunit RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (330 aa)
SFS16861.1DNA gyrase subunit B. (639 aa)
Your Current Organism:
Clostridium citroniae
NCBI taxonomy Id: 358743
Other names: CCUG 52203, Clostridium citroniae Warren et al. 2007, DSM 19261, [. citroniae, [Clostridium] citroniae, strain RMA 16102
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