STRINGSTRING
uvrA uvrA SFS13164.1 SFS13164.1 sbcD sbcD addA addA addB addB SFS15671.1 SFS15671.1 uvrC uvrC SFS15895.1 SFS15895.1 polC polC SFS17026.1 SFS17026.1 SFS17150.1 SFS17150.1 SFS18840.1 SFS18840.1 SFS18189.1 SFS18189.1 SFS20335.1 SFS20335.1 ybeY ybeY rnhB rnhB SFS20412.1 SFS20412.1 SFS20466.1 SFS20466.1 rnhA rnhA SFS20483.1 SFS20483.1 recU recU SFS20654.1 SFS20654.1 SFS20022.1 SFS20022.1 SFS21039.1 SFS21039.1 SFS21946.1 SFS21946.1 SFS22292.1 SFS22292.1 uvrB uvrB SFS22123.1 SFS22123.1 SFS22239.1 SFS22239.1 rnc rnc rnz rnz cas5c cas5c cas4 cas4 cas1 cas1 cas2 cas2 SFS23445.1 SFS23445.1 SFS23593.1 SFS23593.1 nfo nfo SFS23525.1 SFS23525.1 rnpA rnpA SFS23694.1 SFS23694.1 nfo-2 nfo-2 SFS23764.1 SFS23764.1 SFR83269.1 SFR83269.1 xseA xseA SFR96294.1 SFR96294.1 SFR96351.1 SFR96351.1 rnr rnr SFR85969.1 SFR85969.1 mutS2 mutS2 SFR87202.1 SFR87202.1 SFR91997.1 SFR91997.1 rny rny SFR93312.1 SFR93312.1 recJ recJ nth nth SFR94227.1 SFR94227.1 SFS02857.1 SFS02857.1 SFS02912.1 SFS02912.1 xth xth SFS04223.1 SFS04223.1 nth-2 nth-2 SFS06675.1 SFS06675.1 SFS10193.1 SFS10193.1 mrnC mrnC SFS12216.1 SFS12216.1 rnj rnj ruvX ruvX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (949 aa)
SFS13164.1Exonuclease SbcC. (977 aa)
sbcDExodeoxyribonuclease I subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (407 aa)
addADNA helicase/exodeoxyribonuclease V, subunit A; ATP-dependent DNA helicase. (1257 aa)
addBDNA helicase/exodeoxyribonuclease V, subunit B; ATP-dependent DNA helicase. (1183 aa)
SFS15671.1Hypothetical protein. (281 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (624 aa)
SFS15895.1DNA polymerase III catalytic subunit, DnaE type. (1161 aa)
polCDNA polymerase III catalytic subunit, PolC type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1539 aa)
SFS17026.1Phosphoribosyl 1,2-cyclic phosphodiesterase. (265 aa)
SFS17150.1Protein of unknown function. (184 aa)
SFS18840.1T/G mismatch-specific endonuclease. (145 aa)
SFS18189.1Hypothetical protein. (329 aa)
SFS20335.1mRNA interferase MazF; Toxic component of a type II toxin-antitoxin (TA) system. (115 aa)
ybeYProbable rRNA maturation factor; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (165 aa)
rnhBRNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (219 aa)
SFS20412.1Putative endonuclease; Belongs to the UPF0102 family. (113 aa)
SFS20466.1Metallo-beta-lactamase family protein. (535 aa)
rnhARibonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (160 aa)
SFS20483.1TIGR00255 family protein. (292 aa)
recURecombination protein U; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family. (177 aa)
SFS20654.1Ribonuclease G. (401 aa)
SFS20022.1DNA polymerase-1. (356 aa)
SFS21039.1Phosphoesterase RecJ domain-containing protein. (322 aa)
SFS21946.1Hypothetical protein. (328 aa)
SFS22292.1Membrane protein; Belongs to the UPF0761 family. (283 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (660 aa)
SFS22123.1Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains. (623 aa)
SFS22239.1Uncharacterized conserved protein, LabA/DUF88 family. (312 aa)
rncRibonuclease-3; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (230 aa)
rnzRibonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (303 aa)
cas5cCRISPR-associated protein Cas5d. (219 aa)
cas4CRISPR-associated exonuclease, Cas4 family; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (211 aa)
cas1CRISP-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (350 aa)
cas2CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (96 aa)
SFS23445.15-methylcytosine-specific restriction enzyme B. (570 aa)
SFS23593.1Hypothetical protein. (238 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (327 aa)
SFS23525.1Protein of unknown function. (112 aa)
rnpARibonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (114 aa)
SFS23694.1DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] (372 aa)
nfo-2Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (277 aa)
SFS23764.1Hypothetical protein. (466 aa)
SFR83269.1Inhibitor of the KinA pathway to sporulation, predicted exonuclease. (323 aa)
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (423 aa)
SFR96294.1Exodeoxyribonuclease VII small subunit. (77 aa)
SFR96351.1Uncharacterized protein. (172 aa)
rnrRibonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (755 aa)
SFR85969.1TatD DNase family protein. (262 aa)
mutS2DNA mismatch repair protein MutS2; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (812 aa)
SFR87202.13'-5' exoribonuclease. (317 aa)
SFR91997.1mRNA interferase MazF; Toxic component of a type II toxin-antitoxin (TA) system. (138 aa)
rnyRibonucrease Y; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. (516 aa)
SFR93312.1Ribonuclease Z. (267 aa)
recJExonuclease RecJ. (579 aa)
nthEndonuclease-3; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (213 aa)
SFR94227.1MutS domain V; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity. Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (649 aa)
SFS02857.1Hypothetical protein. (304 aa)
SFS02912.1Beta-lactamase superfamily domain-containing protein. (227 aa)
xthExodeoxyribonuclease-3. (251 aa)
SFS04223.1Hypothetical protein. (329 aa)
nth-2DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (223 aa)
SFS06675.1DNA polymerase-3 subunit alpha. (240 aa)
SFS10193.1HDIG domain-containing protein. (198 aa)
mrnCRibonuclease-3 family protein; Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors; Belongs to the MrnC RNase family. (180 aa)
SFS12216.1Hypothetical protein. (299 aa)
rnjRibonuclease J; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (748 aa)
ruvXPutative holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (148 aa)
Your Current Organism:
Clostridium citroniae
NCBI taxonomy Id: 358743
Other names: CCUG 52203, Clostridium citroniae Warren et al. 2007, DSM 19261, [. citroniae, [Clostridium] citroniae, strain RMA 16102
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