(32 nodes) Homologous recombination network (Clostridium citroniae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SFS00626.1	WYL domain-containing protein. (439 aa)
	recF	DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (360 aa)
	SFS23694.1	DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] (372 aa)
	ruvA	Holliday junction DNA helicase subunit RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (209 aa)
	ruvB	Holliday junction DNA helicase subunit RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (330 aa)
	SFS23062.1	Transcriptional regulator, AbrB family. (87 aa)
	holB	DNA polymerase-3 subunit delta'. (329 aa)
	recR	DNA replication and repair protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa)
	dnaX	DNA polymerase-3 subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (539 aa)
	SFS21484.1	DNA polymerase III, delta subunit. (325 aa)
	SFS20022.1	DNA polymerase-1. (356 aa)
	recG	ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (685 aa)
	SFS20291.1	Single-strand binding protein family protein. (209 aa)
	SFS19119.1	Hypothetical protein. (142 aa)
	SFS19115.1	Looped-hinge helix DNA binding domain-containing protein, AbrB family. (96 aa)
	SFS19014.1	Type IV secretory pathway, VirD2 components (relaxase). (444 aa)
	SFS18913.1	Relaxase/Mobilisation nuclease domain-containing protein. (541 aa)
	SFS18866.1	Hypothetical protein. (70 aa)
	polA	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (928 aa)
	polC	DNA polymerase III catalytic subunit, PolC type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1539 aa)
	priA	Replication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (752 aa)
	SFS15895.1	DNA polymerase III catalytic subunit, DnaE type. (1161 aa)
	SFS12751.1	Predicted DNA-binding transcriptional regulator YafY, contains an HTH and WYL domains. (303 aa)
	recO	DNA replication and repair protein RecO; Involved in DNA repair and RecF pathway recombination. (216 aa)
	recD2	Exodeoxyribonuclease V alpha subunit; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (763 aa)
	SFS06675.1	DNA polymerase-3 subunit alpha. (240 aa)
	ssb	Single-strand DNA-binding protein. (128 aa)
	SFS00611.1	WYL domain-containing protein. (343 aa)
	recJ	Exonuclease RecJ. (579 aa)
	recA	Recombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (378 aa)
	SFR86001.1	AAA domain-containing protein, putative AbiEii toxin, Type IV TA system. (345 aa)
	SFR96382.1	Foldase protein PrsA. (334 aa)

Your Current Organism:

Clostridium citroniae

NCBI taxonomy Id: 358743
Other names: CCUG 52203, Clostridium citroniae Warren et al. 2007, DSM 19261, [. citroniae, [Clostridium] citroniae, strain RMA 16102

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFR86001.1	SFS23694.1	SAMN05216568_101253	SAMN05216568_11717	AAA domain-containing protein, putative AbiEii toxin, Type IV TA system.	DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...]	0.733
SFR86001.1	polA	SAMN05216568_101253	SAMN05216568_104431	AAA domain-containing protein, putative AbiEii toxin, Type IV TA system.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.578
SFR86001.1	recO	SAMN05216568_101253	SAMN05216568_103362	AAA domain-containing protein, putative AbiEii toxin, Type IV TA system.	DNA replication and repair protein RecO; Involved in DNA repair and RecF pathway recombination.	0.416
SFR96382.1	SFS20291.1	SAMN05216568_1011280	SAMN05216568_106153	Foldase protein PrsA.	Single-strand binding protein family protein.	0.491
SFR96382.1	polA	SAMN05216568_1011280	SAMN05216568_104431	Foldase protein PrsA.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.475
SFR96382.1	recO	SAMN05216568_1011280	SAMN05216568_103362	Foldase protein PrsA.	DNA replication and repair protein RecO; Involved in DNA repair and RecF pathway recombination.	0.567
SFR96382.1	ssb	SAMN05216568_1011280	SAMN05216568_102498	Foldase protein PrsA.	Single-strand DNA-binding protein.	0.491
SFS00611.1	SFS00626.1	SAMN05216568_10232	SAMN05216568_10233	WYL domain-containing protein.	WYL domain-containing protein.	0.959
SFS00611.1	SFS06675.1	SAMN05216568_10232	SAMN05216568_102580	WYL domain-containing protein.	DNA polymerase-3 subunit alpha.	0.435
SFS00611.1	SFS15895.1	SAMN05216568_10232	SAMN05216568_104228	WYL domain-containing protein.	DNA polymerase III catalytic subunit, DnaE type.	0.605
SFS00611.1	SFS18866.1	SAMN05216568_10232	SAMN05216568_105182	WYL domain-containing protein.	Hypothetical protein.	0.590
SFS00611.1	SFS21484.1	SAMN05216568_10232	SAMN05216568_107151	WYL domain-containing protein.	DNA polymerase III, delta subunit.	0.563
SFS00611.1	SFS23694.1	SAMN05216568_10232	SAMN05216568_11717	WYL domain-containing protein.	DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...]	0.563
SFS00611.1	dnaX	SAMN05216568_10232	SAMN05216568_111143	WYL domain-containing protein.	DNA polymerase-3 subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.451
SFS00611.1	holB	SAMN05216568_10232	SAMN05216568_11188	WYL domain-containing protein.	DNA polymerase-3 subunit delta'.	0.451
SFS00611.1	polC	SAMN05216568_10232	SAMN05216568_104364	WYL domain-containing protein.	DNA polymerase III catalytic subunit, PolC type; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.	0.435
SFS00611.1	recG	SAMN05216568_10232	SAMN05216568_106251	WYL domain-containing protein.	ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily.	0.595
SFS00626.1	SFS00611.1	SAMN05216568_10233	SAMN05216568_10232	WYL domain-containing protein.	WYL domain-containing protein.	0.959
SFS00626.1	SFS06675.1	SAMN05216568_10233	SAMN05216568_102580	WYL domain-containing protein.	DNA polymerase-3 subunit alpha.	0.435
SFS00626.1	SFS15895.1	SAMN05216568_10233	SAMN05216568_104228	WYL domain-containing protein.	DNA polymerase III catalytic subunit, DnaE type.	0.605