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aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (366 aa) | ||||
aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa) | ||||
aroG_1 | Phospho-2-dehydro-3-deoxyheptonate aldolase%2C Phe-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (343 aa) | ||||
aroD_1 | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (249 aa) | ||||
cobD_1 | Threonine-phosphate decarboxylase. (364 aa) | ||||
pheA | P-protein. (383 aa) | ||||
pat | Putative phenylalanine aminotransferase. (359 aa) | ||||
hisK_1 | Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (278 aa) | ||||
hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (396 aa) | ||||
hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (222 aa) | ||||
hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa) | ||||
hisB | Histidine biosynthesis bifunctional protein hisB. (195 aa) | ||||
hisE | Phosphoribosyl-ATP pyrophosphatase; In the C-terminal section; belongs to the PRA-PH family. (431 aa) | ||||
aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (366 aa) | ||||
tyrC | Arogenate dehydrogenase. (364 aa) | ||||
hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (352 aa) | ||||
aspC | Aspartate aminotransferase. (398 aa) | ||||
hisK_2 | Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (263 aa) | ||||
aroK_1 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa) | ||||
trpA | Tryptophan synthase alpha chain. (257 aa) | ||||
trpB | Tryptophan synthase beta chain. (396 aa) | ||||
trpF | N-(5'-phosphoribosyl)anthranilate isomerase. (202 aa) | ||||
trpC | Indole-3-glycerol phosphate synthase. (260 aa) | ||||
trpD | Anthranilate synthase component II. (343 aa) | ||||
trpG | Anthranilate synthase component II. (189 aa) | ||||
trpE | Anthranilate synthase component 1. (488 aa) | ||||
aroE_1 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (289 aa) | ||||
aroK_2 | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (269 aa) | ||||
aroD_2 | 3-dehydroquinate dehydratase. (253 aa) | ||||
ydiM | Inner membrane transport protein ydiM. (404 aa) | ||||
aroE_2 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (292 aa) | ||||
hcaR | Hca operon transcriptional activator. (293 aa) | ||||
CUO33939.1 | Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (275 aa) | ||||
hisA | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)m ethylideneamino] imidazole-4-carboxamide isomerase; Belongs to the HisA/HisF family. (258 aa) | ||||
hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa) | ||||
hisH1 | Imidazole glycerol phosphate synthase subunit HisH 1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (201 aa) | ||||
aroG_2 | Phospho-2-dehydro-3-deoxyheptonate aldolase%2C Phe-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (350 aa) |