STRINGSTRING
ACQ69014.1 ACQ69014.1 ACQ69015.1 ACQ69015.1 hisG hisG hisD hisD ACQ69018.1 ACQ69018.1 hisB hisB hisH hisH hisA hisA hisF hisF ACQ69023.1 ACQ69023.1 hisE hisE ACQ69027.1 ACQ69027.1 ACQ69078.1 ACQ69078.1 aroK aroK ACQ69631.1 ACQ69631.1 trpE trpE ACQ70045.1 ACQ70045.1 trpA trpA trpB trpB trpF trpF trpC trpC trpD trpD ACQ70592.1 ACQ70592.1 ACQ70593.1 ACQ70593.1 ACQ70594.1 ACQ70594.1 ACQ70595.1 ACQ70595.1 ACQ70596.1 ACQ70596.1 ACQ70597.1 ACQ70597.1 ACQ70598.1 ACQ70598.1 ACQ71181.1 ACQ71181.1 ACQ71182.1 ACQ71182.1 asd asd dapA dapA dapB dapB dapH dapH ACQ71190.1 ACQ71190.1 aroE aroE aroC aroC aroB aroB aroA aroA ACQ71935.1 ACQ71935.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ACQ69014.1TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP domain protein; KEGG: bha:BH3206 histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (272 aa)
ACQ69015.1PFAM: tRNA synthetase class II (G H P and S); KEGG: bcb:BCB4264_A1457 ATP phosphoribosyltransferase, regulatory subunit. (307 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (202 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (405 aa)
ACQ69018.1PFAM: aminotransferase class I and II; KEGG: tcx:Tcr_1194 histidinol-phosphate aminotransferase. (338 aa)
hisBPFAM: imidazoleglycerol-phosphate dehydratase; KEGG: rpd:RPD_0415 imidazoleglycerol-phosphate dehydratase. (195 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (195 aa)
hisATIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: sat:SYN_00761 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (237 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (255 aa)
ACQ69023.1Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. (110 aa)
hisETIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; MazG nucleotide pyrophosphohydrolase; KEGG: bsu:BSU34860 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein. (102 aa)
ACQ69027.1PFAM: aminotransferase class I and II; KEGG: His8; Histidinol-phosphate aminotransferase, chloroplast precursor, probable; K00817 histidinol-phosphate aminotransferase. (337 aa)
ACQ69078.1PFAM: FAD dependent oxidoreductase; KEGG: bcy:Bcer98_1848 FAD dependent oxidoreductase. (370 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (162 aa)
ACQ69631.1TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; chorismate mutase; PFAM: DAHP synthetase I/KDSA; Chorismate mutase; KEGG: bcy:Bcer98_3343 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase. (363 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (443 aa)
ACQ70045.1TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: dol:Dole_1568 glutamine amidotransferase of anthranilate synthase. (191 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (255 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: bcr:BCAH187_A1397 N-(5'phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (184 aa)
trpCPFAM: Indole-3-glycerol phosphate synthase; KEGG: bcz:BCZK1133 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (253 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (329 aa)
ACQ70592.1TIM-barrel protein, nifR3 family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (331 aa)
ACQ70593.1KEGG: dar:Daro_3183 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK. (165 aa)
ACQ70594.1Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (121 aa)
ACQ70595.1Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (261 aa)
ACQ70596.1PFAM: aminotransferase class IV; KEGG: bcy:Bcer98_0066 4-amino-4-deoxychorismate lyase. (272 aa)
ACQ70597.1TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: bsu:BSU00750 para-aminobenzoate/anthranilate synthase glutamine amidotransferase component II. (194 aa)
ACQ70598.1Anthranilate synthase; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein; KEGG: bcr:BCAH187_A0080 para-aminobenzoate synthase, component I. (459 aa)
ACQ71181.1PFAM: GCN5-related N-acetyltransferase; KEGG: csa:Csal_2448 GCN5-related N-acetyltransferase. (142 aa)
ACQ71182.1KEGG: cha:CHAB381_0999 aspartate kinase; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (405 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (331 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (249 aa)
dapHTetrahydrodipicolinate succinyltransferase domain protein; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (235 aa)
ACQ71190.1PFAM: nitroreductase; KEGG: bcy:Bcer98_0644 nitroreductase. (196 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (261 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (387 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (351 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (416 aa)
ACQ71935.1PFAM: aminotransferase class I and II; KEGG: bcr:BCAH187_A1712 aspartate aminotransferase. (395 aa)
Your Current Organism:
Exiguobacterium sp. AT1b
NCBI taxonomy Id: 360911
Other names: E. sp. AT1b
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