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fumC fumC ACQ69089.1 ACQ69089.1 ACQ69313.1 ACQ69313.1 ACQ69325.1 ACQ69325.1 ACQ69336.1 ACQ69336.1 ACQ69349.1 ACQ69349.1 ACQ69402.1 ACQ69402.1 ACQ69437.1 ACQ69437.1 ACQ69438.1 ACQ69438.1 ACQ69439.1 ACQ69439.1 ACQ69440.1 ACQ69440.1 buk buk ACQ69442.1 ACQ69442.1 ACQ69443.1 ACQ69443.1 ldh ldh ACQ69589.1 ACQ69589.1 mdh mdh ACQ69597.1 ACQ69597.1 ACQ69598.1 ACQ69598.1 ACQ69600.1 ACQ69600.1 pfkA pfkA ackA ackA ACQ69626.1 ACQ69626.1 pckA pckA pgi pgi ACQ69717.1 ACQ69717.1 ACQ69725.1 ACQ69725.1 ldh-2 ldh-2 ACQ69745.1 ACQ69745.1 ACQ69746.1 ACQ69746.1 ACQ69747.1 ACQ69747.1 eno eno gpmI gpmI tpiA tpiA pgk pgk ACQ69793.1 ACQ69793.1 ACQ70273.1 ACQ70273.1 tal tal ACQ70276.1 ACQ70276.1 ACQ70288.1 ACQ70288.1 ACQ70371.1 ACQ70371.1 ACQ70388.1 ACQ70388.1 ACQ70412.1 ACQ70412.1 ACQ70440.1 ACQ70440.1 ACQ70464.1 ACQ70464.1 ACQ70716.1 ACQ70716.1 mqo mqo ACQ70725.1 ACQ70725.1 ACQ70808.1 ACQ70808.1 ACQ70879.1 ACQ70879.1 ACQ71067.1 ACQ71067.1 ACQ71260.1 ACQ71260.1 ACQ71272.1 ACQ71272.1 ACQ71273.1 ACQ71273.1 ACQ71390.1 ACQ71390.1 ACQ71420.1 ACQ71420.1 odhA odhA ACQ71458.1 ACQ71458.1 ACQ71527.1 ACQ71527.1 ACQ71528.1 ACQ71528.1 ACQ71529.1 ACQ71529.1 ACQ71530.1 ACQ71530.1 ACQ71543.1 ACQ71543.1 ACQ71544.1 ACQ71544.1 ACQ71545.1 ACQ71545.1 pdhA pdhA ACQ71700.1 ACQ71700.1 ACQ71701.1 ACQ71701.1 ACQ71702.1 ACQ71702.1 ACQ71719.1 ACQ71719.1 sucC sucC sucD sucD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa)
ACQ69089.1PFAM: iron-containing alcohol dehydrogenase; Aldehyde Dehydrogenase; KEGG: bcr:BCAH187_A4504 aldehyde-alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (863 aa)
ACQ69313.1PFAM: 6-phosphogluconate dehydrogenase NAD-binding; NADP oxidoreductase coenzyme F420-dependent; KEGG: bsu:BSU13960 hypothetical protein. (290 aa)
ACQ69325.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
ACQ69336.1TIGRFAM: transketolase; PFAM: Transketolase central region; Transketolase domain protein; KEGG: bce:BC3682 transketolase; Belongs to the transketolase family. (660 aa)
ACQ69349.1PFAM: Phosphoglycerate mutase; KEGG: bcr:BCAH187_C0209 phosphoglycerate mutase family protein. (186 aa)
ACQ69402.1PFAM: Aldehyde Dehydrogenase; KEGG: bcy:Bcer98_0684 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (478 aa)
ACQ69437.1PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; KEGG: bcy:Bcer98_2854 branched-chain alpha-keto acid dehydrogenase subunit E2. (439 aa)
ACQ69438.1PFAM: Transketolase central region; Transketolase domain protein; KEGG: bcb:BCB4264_A4271 3-methyl-2-oxobutanoate dehydrogenase, beta subunit. (325 aa)
ACQ69439.13-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring); PFAM: dehydrogenase E1 component; KEGG: bha:BH2763 branched-chain alpha-keto acid dehydrogenase E1. (335 aa)
ACQ69440.1TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: bcb:BCB4264_A4273 3-methyl-2-oxobutanoate dehydrogenase complex, dihydrolipoamide dehydrogenase component. (469 aa)
bukTIGRFAM: butyrate kinase; PFAM: acetate and butyrate kinase; KEGG: bce:BC4161 butyrate kinase; Belongs to the acetokinase family. (363 aa)
ACQ69442.1PFAM: Glu/Leu/Phe/Val dehydrogenase dimerisation region; Glu/Leu/Phe/Val dehydrogenase; KEGG: bsu:BSU24080 leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (373 aa)
ACQ69443.1PFAM: phosphate acetyl/butaryl transferase; KEGG: bcb:BCB4264_A4276 phosphate butyryltransferase. (298 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (318 aa)
ACQ69589.1KEGG: bha:BH3149 glyceraldehyde-3-phosphate dehydrogenase; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (343 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (310 aa)
ACQ69597.1KEGG: bsu:BSU29130 isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase. (423 aa)
ACQ69598.1KEGG: bha:BH3160 methylcitrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; Belongs to the citrate synthase family. (370 aa)
ACQ69600.1TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; PEP-utilising protein mobile region; Pyruvate kinase alpha/beta; KEGG: bcy:Bcer98_3282 pyruvate kinase; Belongs to the pyruvate kinase family. (580 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (322 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (403 aa)
ACQ69626.1PFAM: AMP-dependent synthetase and ligase; KEGG: bha:BH3234 acetyl-CoA synthetase. (570 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (523 aa)
pgiPFAM: phosphoglucose isomerase (PGI); KEGG: bcz:BCZK4630 glucose-6-phosphate isomerase; Belongs to the GPI family. (450 aa)
ACQ69717.1Fructose-1,6-bisphosphatase, class II; KEGG: bcy:Bcer98_3560 fructose 1,6-bisphosphatase II; TIGRFAM: fructose-1,6-bisphosphatase, class II; PFAM: GlpX family protein. (326 aa)
ACQ69725.1PFAM: acylphosphatase; KEGG: pmu:PM0396 hypothetical protein. (90 aa)
ldh-2L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (327 aa)
ACQ69745.1PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase type 2 domain; KEGG: bha:BH3486 butyryl-CoA dehydrogenase. (594 aa)
ACQ69746.1KEGG: bcy:Bcer98_3596 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
ACQ69747.1PFAM: 3-hydroxyacyl-CoA dehydrogenase NAD-binding; Enoyl-CoA hydratase/isomerase; 3-hydroxyacyl-CoA dehydrogenase domain protein; KEGG: bca:BCE_5144 3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase/isomerase family protein. (803 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
gpmIPhosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (512 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa)
pgkPFAM: phosphoglycerate kinase; KEGG: bcy:Bcer98_3681 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (394 aa)
ACQ69793.1Glyceraldehyde-3-phosphate dehydrogenase, type I; KEGG: nma:NMA0246 glyceraldehyde 3-phosphate dehydrogenase C; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
ACQ70273.1KEGG: bcb:BCB4264_A5456 fructose-1,6-bisphosphatase, class II; TIGRFAM: fructose-1,6-bisphosphatase, class II; PFAM: GlpX family protein. (323 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (216 aa)
ACQ70276.1Fructose-1,6-bisphosphate aldolase, class II; KEGG: bcy:Bcer98_3856 fructose-bisphosphate aldolase; TIGRFAM: fructose-1,6-bisphosphate aldolase, class II; ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II. (284 aa)
ACQ70288.1PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; KEGG: bha:BH3802 iron-sulphur-binding reductase. (708 aa)
ACQ70371.1TIGRFAM: phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; KEGG: bcb:BCB4264_A5510 phosphate acetyltransferase. (329 aa)
ACQ70388.1PFAM: Aldehyde Dehydrogenase; KEGG: bcr:BCAH187_A0401 succinate-semialdehyde dehydrogenase (NADP+). (470 aa)
ACQ70412.1TIGRFAM: quinone oxidoreductase, YhdH/YhfP family; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: pnu:Pnuc_1984 alcohol dehydrogenase. (330 aa)
ACQ70440.1KEGG: bcy:Bcer98_1171 mannose-6-phosphate isomerase, class I; TIGRFAM: mannose-6-phosphate isomerase, class I; PFAM: mannose-6-phosphate isomerase type I. (346 aa)
ACQ70464.1PFAM: Aldehyde Dehydrogenase; KEGG: bha:BH2010 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (485 aa)
ACQ70716.1PFAM: Phosphoglycerate mutase; KEGG: bha:BH0285 hypothetical protein. (180 aa)
mqoKEGG: bcb:BCB4264_A2975 malate:quinone-oxidoreductase; TIGRFAM: malate/quinone oxidoreductase; PFAM: Malate:quinone-oxidoreductase; FAD dependent oxidoreductase. (499 aa)
ACQ70725.1PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: bcy:Bcer98_0768 alcohol dehydrogenase. (342 aa)
ACQ70808.1TIGRFAM: mannose-6-phosphate isomerase, class I; PFAM: ROK family protein; mannose-6-phosphate isomerase type I; KEGG: bha:BH3916 mannose-6-phosphate isomerase. (595 aa)
ACQ70879.1PFAM: short-chain dehydrogenase/reductase SDR; KEGG: bcy:Bcer98_3132 glucose-1-dehydrogenase. (265 aa)
ACQ71067.1PFAM: amine oxidase; FAD dependent oxidoreductase; KEGG: vsa:VSAL_II0981 putative flavin containing amine oxidoreductase. (343 aa)
ACQ71260.1PFAM: Aldehyde Dehydrogenase; KEGG: bha:BH0865 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (461 aa)
ACQ71272.1KEGG: bcy:Bcer98_0431 formate acetyltransferase; TIGRFAM: formate acetyltransferase; PFAM: pyruvate formate-lyase PFL; formate C-acetyltransferase glycine radical. (748 aa)
ACQ71273.1Pyruvate formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (238 aa)
ACQ71390.1PFAM: AMP-dependent synthetase and ligase; KEGG: bcb:BCB4264_A1123 putative long-chain-fatty-acid--CoA ligase. (515 aa)
ACQ71420.1PFAM: Enoyl-CoA hydratase/isomerase; KEGG: bha:BH0202 enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (244 aa)
odhA2-oxoglutarate dehydrogenase, E1 subunit; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (951 aa)
ACQ71458.12-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (424 aa)
ACQ71527.1PFAM: AMP-dependent synthetase and ligase; KEGG: bcr:BCAH187_A4654 long-chain-fatty-acid--CoA ligase. (557 aa)
ACQ71528.1PFAM: Tetracycline transcriptional regulator YsiA domain protein; regulatory protein TetR; KEGG: bha:BH3102 TetR/AcrR family transcriptional regulator. (192 aa)
ACQ71529.1PFAM: Electron transfer flavoprotein alpha/beta-subunit; KEGG: bcr:BCAH187_A4651 electron transfer flavoprotein, beta subunit. (257 aa)
ACQ71530.1PFAM: Electron transfer flavoprotein alpha/beta-subunit; thiamine pyrophosphate protein central region; Electron transfer flavoprotein alpha subunit; KEGG: bsu:BSU28520 electron transfer flavoprotein (alpha subunit). (321 aa)
ACQ71543.1TIGRFAM: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; PFAM: fumarate reductase respiratory complex transmembrane subunit; KEGG: bha:BH3093 succinate dehydrogenase cytochrome b-558. (205 aa)
ACQ71544.1TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: bcy:Bcer98_3216 succinate dehydrogenase flavoprotein subunit. (585 aa)
ACQ71545.1TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; KEGG: bsu:BSU28430 succinate dehydrogenase iron-sulfur subunit. (266 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (361 aa)
ACQ71700.1PFAM: Transketolase central region; Transketolase domain protein; KEGG: bha:BH2654 pyruvate dehydrogenase E1 (lipoamide) beta subunit. (325 aa)
ACQ71701.1PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; KEGG: bha:BH2653 branched-chain alpha-keto acid dehydrogenase subunit E2. (429 aa)
ACQ71702.1TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: bcy:Bcer98_2671 dihydrolipoamide dehydrogenase. (470 aa)
ACQ71719.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1144 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (305 aa)
Your Current Organism:
Exiguobacterium sp. AT1b
NCBI taxonomy Id: 360911
Other names: E. sp. AT1b
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