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pdxT pdxT hisB hisB hisH hisH hisF hisF ACQ69025.1 ACQ69025.1 fumC fumC ACQ69162.1 ACQ69162.1 argH argH ACQ69325.1 ACQ69325.1 ACQ69387.1 ACQ69387.1 aroQ aroQ deoC deoC luxS luxS speH speH mutM mutM ACQ69631.1 ACQ69631.1 pckA pckA ACQ69685.1 ACQ69685.1 eno eno ribBA ribBA ACQ69974.1 ACQ69974.1 ACQ70000.1 ACQ70000.1 ACQ70009.1 ACQ70009.1 ACQ70045.1 ACQ70045.1 ACQ70112.1 ACQ70112.1 ACQ70142.1 ACQ70142.1 ACQ70209.1 ACQ70209.1 fabZ fabZ ACQ70258.1 ACQ70258.1 tal tal ACQ70276.1 ACQ70276.1 ACQ70304.1 ACQ70304.1 murQ murQ ACQ70352.1 ACQ70352.1 ACQ70356.1 ACQ70356.1 ACQ70363.1 ACQ70363.1 mtnB mtnB trpA trpA trpB trpB trpC trpC ACQ70452.1 ACQ70452.1 dacA dacA ispF ispF ACQ70594.1 ACQ70594.1 ACQ70597.1 ACQ70597.1 pdxS pdxS ACQ70737.1 ACQ70737.1 mgsA mgsA ACQ70785.1 ACQ70785.1 ACQ70822.1 ACQ70822.1 moaA moaA moaC moaC queE queE ACQ70916.1 ACQ70916.1 ACQ70984.1 ACQ70984.1 ACQ71017.1 ACQ71017.1 purK purK ACQ71147.1 ACQ71147.1 dapA dapA lysA lysA ACQ71233.1 ACQ71233.1 menB menB ACQ71298.1 ACQ71298.1 hemE hemE hemH hemH ACQ71417.1 ACQ71417.1 ACQ71419.1 ACQ71419.1 ACQ71434.1 ACQ71434.1 ACQ71483.1 ACQ71483.1 ACQ71560.1 ACQ71560.1 ACQ71561.1 ACQ71561.1 ACQ71626.1 ACQ71626.1 mltG mltG ACQ71720.1 ACQ71720.1 pyrF pyrF ACQ71779.1 ACQ71779.1 ACQ71793.1 ACQ71793.1 ACQ71794.1 ACQ71794.1 aroC aroC aroB aroB panD panD nth nth
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
pdxTSNO glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (192 aa)
hisBPFAM: imidazoleglycerol-phosphate dehydratase; KEGG: rpd:RPD_0415 imidazoleglycerol-phosphate dehydratase. (195 aa)
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (195 aa)
hisFImidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (255 aa)
ACQ69025.1KEGG: pmu:PM0373 hypothetical protein. (307 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (466 aa)
ACQ69162.1PFAM: Carboxymuconolactone decarboxylase; KEGG: hhe:HH1468 hypothetical protein. (133 aa)
argHTIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: bsu:BSU29440 argininosuccinate lyase. (462 aa)
ACQ69325.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (904 aa)
ACQ69387.1PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: bat:BAS3152 glyoxylase family protein. (126 aa)
aroQ3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (145 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (221 aa)
luxSQuorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (155 aa)
speHS-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (128 aa)
mutMformamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (275 aa)
ACQ69631.1TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; chorismate mutase; PFAM: DAHP synthetase I/KDSA; Chorismate mutase; KEGG: bcy:Bcer98_3343 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase. (363 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (523 aa)
ACQ69685.1PFAM: Scaffold protein Nfu/NifU; KEGG: bsu:BSU21880 hypothetical protein. (82 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)
ribBA3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (391 aa)
ACQ69974.1KEGG: vvy:VVA1509 tagatose-bisphosphate aldolase; TIGRFAM: class II aldolase, tagatose bisphosphate family; ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II. (289 aa)
ACQ70000.1PFAM: Heparinase II/III family protein; KEGG: bcz:BCZK4968 hypothetical protein. (689 aa)
ACQ70009.1PFAM: Heparinase II/III family protein; KEGG: bcz:BCZK4968 hypothetical protein. (694 aa)
ACQ70045.1TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: dol:Dole_1568 glutamine amidotransferase of anthranilate synthase. (191 aa)
ACQ70112.1TIGRFAM: dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; dTDP-4-dehydrorhamnose reductase; Male sterility domain; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; KEGG: gsu:GSU2366 dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (350 aa)
ACQ70142.1PFAM: TM1410 hypothetical-related protein; KEGG: bcr:BCAH187_A5630 hypothetical protein. (285 aa)
ACQ70209.1PFAM: deoxyribodipyrimidine photolyase-related protein; DNA photolyase FAD-binding; KEGG: eli:ELI_08725 hypothetical protein. (493 aa)
fabZBeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (140 aa)
ACQ70258.1PFAM: ThiJ/PfpI domain protein; KEGG: mlo:mlr4512 hypothetical protein. (235 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (216 aa)
ACQ70276.1Fructose-1,6-bisphosphate aldolase, class II; KEGG: bcy:Bcer98_3856 fructose-bisphosphate aldolase; TIGRFAM: fructose-1,6-bisphosphate aldolase, class II; ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II. (284 aa)
ACQ70304.1PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; Male sterility domain; polysaccharide biosynthesis protein CapD; short-chain dehydrogenase/reductase SDR; dTDP-4-dehydrorhamnose reductase; KEGG: sat:SYN_01112 UDP-N-acetylglucosamine 4-epimerase. (342 aa)
murQGlucokinase regulatory-like protein; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (294 aa)
ACQ70352.1PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: ilo:IL2539 threonine aldolase putative. (352 aa)
ACQ70356.1PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: rpi:Rpic_3001 glyoxalase/bleomycin resistance protein/dioxygenase. (126 aa)
ACQ70363.1PFAM: ribulose bisphosphate carboxylase large chain; KEGG: bcr:BCAH187_A4167 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Belongs to the RuBisCO large chain family. (384 aa)
mtnBMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (205 aa)
trpATryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (255 aa)
trpBTryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa)
trpCPFAM: Indole-3-glycerol phosphate synthase; KEGG: bcz:BCZK1133 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (253 aa)
ACQ70452.1PFAM: NmrA family protein; NAD-dependent epimerase/dehydratase; Male sterility domain; TrkA-N domain protein; KEGG: bsu:BSU10260 hypothetical protein. (212 aa)
dacAProtein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (286 aa)
ispF2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa)
ACQ70594.1Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (121 aa)
ACQ70597.1TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: bsu:BSU00750 para-aminobenzoate/anthranilate synthase glutamine amidotransferase component II. (194 aa)
pdxSPyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (296 aa)
ACQ70737.1KEGG: pcr:Pcryo_0017 HNH endonuclease. (272 aa)
mgsAMethylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (137 aa)
ACQ70785.1PFAM: ThiJ/PfpI domain protein; KEGG: bca:BCE_4593 ThiJ/PfpI family protein. (219 aa)
ACQ70822.1TIGRFAM: isocitrate lyase; PFAM: isocitrate lyase and phosphorylmutase; KEGG: bcr:BCAH187_A1287 isocitrate lyase. (425 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (335 aa)
moaCMolybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (154 aa)
queE7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (236 aa)
ACQ70916.1PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: bcb:BCB4264_A1395 putative 6-pyruvoyl tetrahydrobiopterin synthase. (152 aa)
ACQ70984.1PFAM: transcriptional coactivator/pterin dehydratase; KEGG: aba:Acid345_2331 pterin-4-alpha-carbinolamine dehydratase. (91 aa)
ACQ71017.1PFAM: ThiJ/PfpI domain protein; KEGG: abo:ABO_2639 hypothetical protein. (220 aa)
purKPhosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (364 aa)
ACQ71147.1TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: bha:BH0625 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (430 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (430 aa)
ACQ71233.1PFAM: NmrA family protein; Male sterility domain; NAD-dependent epimerase/dehydratase; KEGG: maq:Maqu_2944 NAD-dependent epimerase/dehydratase. (235 aa)
menBNaphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). (274 aa)
ACQ71298.1PFAM: carbonic anhydrase; KEGG: bsu:BSU34670 hypothetical protein. (183 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (349 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (309 aa)
ACQ71417.1KEGG: bid:Bind_2275 membrane protein-like protein. (249 aa)
ACQ71419.1TIGRFAM: ybaK/ebsC protein; PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: bcy:Bcer98_2119 YbaK/EbsC protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (154 aa)
ACQ71434.1Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (259 aa)
ACQ71483.1PFAM: VanZ family protein; KEGG: bcy:Bcer98_3778 hypothetical protein. (172 aa)
ACQ71560.1Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (210 aa)
ACQ71561.1Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: bcy:Bcer98_3178 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (326 aa)
ACQ71626.1Cryptochrome, DASH family; KEGG: predicted protein; TIGRFAM: cryptochrome, DASH family; PFAM: DNA photolyase FAD-binding. (404 aa)
mltGAminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (380 aa)
ACQ71720.1Deoxyribodipyrimidine photo-lyase; PFAM: DNA photolyase FAD-binding; DNA photolyase domain protein; KEGG: aci:ACIAD1182 deoxyribodipyrimidine photolyase (photoreactivation), FAD-binding. (450 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (234 aa)
ACQ71779.1Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (396 aa)
ACQ71793.1KEGG: bha:BH2497 L-serine dehydratase beta subunit; TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; PFAM: serine dehydratase beta chain; amino acid-binding ACT domain protein. (220 aa)
ACQ71794.1KEGG: bsu:BSU15860 L-serine dehydratase (alpha chain); TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: serine dehydratase alpha chain. (295 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (387 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (351 aa)
panDAspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (219 aa)
Your Current Organism:
Exiguobacterium sp. AT1b
NCBI taxonomy Id: 360911
Other names: E. sp. AT1b
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