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DLAC_11801 DLAC_11801 DLAC_09657 DLAC_09657 DLAC_09751 DLAC_09751 DLAC_08690 DLAC_08690 DLAC_08816 DLAC_08816 DLAC_09041 DLAC_09041 DLAC_09135 DLAC_09135 DLAC_09293 DLAC_09293 DLAC_08016 DLAC_08016 DLAC_08049 DLAC_08049 DLAC_08375 DLAC_08375 DLAC_07263 DLAC_07263 DLAC_07299 DLAC_07299 DLAC_07316 DLAC_07316 DLAC_07433 DLAC_07433 DLAC_07438 DLAC_07438 pyrK pyrK DLAC_06772 DLAC_06772 DLAC_06643 DLAC_06643 DLAC_06694 DLAC_06694 DLAC_06733 DLAC_06733 DLAC_05616 DLAC_05616 DLAC_05734 DLAC_05734 DLAC_05730 DLAC_05730 DLAC_05977 DLAC_05977 DLAC_04948 DLAC_04948 DLAC_04873 DLAC_04873 DLAC_04010 DLAC_04010 DLAC_03950 DLAC_03950 DLAC_03719 DLAC_03719 DLAC_03885 DLAC_03885 DLAC_11522 DLAC_11522 DLAC_02706 DLAC_02706 DLAC_02677 DLAC_02677 DLAC_02945 DLAC_02945 DLAC_02885 DLAC_02885 DLAC_02064 DLAC_02064 DLAC_01776 DLAC_01776 DLAC_00934 DLAC_00934 DLAC_00484 DLAC_00484
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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DLAC_11801Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (276 aa)
DLAC_09657Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (186 aa)
DLAC_097515'-nucleotidase. (604 aa)
DLAC_08690Uridine phosphorylase. (251 aa)
DLAC_08816Ribonucleotide reductase small subunit. (339 aa)
DLAC_09041GMP synthetase. (714 aa)
DLAC_09135Adenosine kinase. (344 aa)
DLAC_09293Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity; Belongs to the adenylate kinase family. AK6 subfamily. (181 aa)
DLAC_08016NDK domain-containing protein. (152 aa)
DLAC_08049TPR_REGION domain-containing protein. (442 aa)
DLAC_08375dCTP deaminase. (171 aa)
DLAC_07263Adenosine deaminase. (749 aa)
DLAC_07299Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (852 aa)
DLAC_07316Uridine phosphorylase. (287 aa)
DLAC_07433AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (780 aa)
DLAC_07438Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (144 aa)
pyrKUMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (196 aa)
DLAC_06772Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (515 aa)
DLAC_06643Uridine-cytidine kinase; Belongs to the uridine kinase family. (253 aa)
DLAC_06694Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (426 aa)
DLAC_06733Adenylate kinase; Belongs to the adenylate kinase family. (250 aa)
DLAC_05616Uridine-cytidine kinase; Belongs to the uridine kinase family. (462 aa)
DLAC_05734Thymidine kinase. (117 aa)
DLAC_05730dUTP diphosphatase. (145 aa)
DLAC_05977Uncharacterized protein. (617 aa)
DLAC_04948Bifunctional UMP-synthetase. (479 aa)
DLAC_04873dCTP deaminase. (246 aa)
DLAC_04010Guanylate kinase-like domain-containing protein. (171 aa)
DLAC_03950Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (186 aa)
DLAC_03719Thymidylate kinase. (216 aa)
DLAC_03885Uracil phosphoribosyltransferase. (210 aa)
DLAC_11522Str_synth domain-containing protein. (415 aa)
DLAC_02706CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (584 aa)
DLAC_02677Adenylate cyclase domain-containing protein. (498 aa)
DLAC_02945Guanosine-3. (206 aa)
DLAC_02885Adenine phosphoribosyltransferase. (199 aa)
DLAC_02064Glutamine amidotransferase class-I domain-containing protein. (260 aa)
DLAC_01776Adenylate cyclase domain-containing protein. (425 aa)
DLAC_00934Nucleoside diphosphate kinase. (221 aa)
DLAC_00484Adenosine deaminase-related growth factor. (524 aa)
Your Current Organism:
Tieghemostelium lacteum
NCBI taxonomy Id: 361077
Other names: Dictyostelium lacteum, T. lacteum
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