(49 nodes) Valine, leucine and isoleucine degradation network (Tieghemostelium lacteum)

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Your Input:
	DLAC_09784	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. (524 aa)
	DLAC_00166	Methylmalonyl-coenzyme A mutase. (744 aa)
	DLAC_11472	Uncharacterized protein. (418 aa)
	DLAC_01220	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (384 aa)
	DLAC_01885	SET domain-containing protein. (446 aa)
	DLAC_01917	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
	DLAC_02154	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (487 aa)
	DLAC_02913	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (486 aa)
	DLAC_02954	3-hydroxyacyl-CoA dehydrogenase type II; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
	DLAC_03181	Propionyl-CoA carboxylase. (674 aa)
	DLAC_02601	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (251 aa)
	DLAC_02486	Propionyl-CoA carboxylase. (570 aa)
	DLAC_03310	Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (418 aa)
	DLAC_03436	SH2 domain-containing protein. (1241 aa)
	DLAC_03770	Transmembrane protein. (186 aa)
	DLAC_03727	Uncharacterized protein. (610 aa)
	DLAC_03993	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (415 aa)
	DLAC_04575	Transportin. (922 aa)
	DLAC_05006	Methylmalonyl-CoA epimerase. (166 aa)
	DLAC_05914	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (505 aa)
	DLAC_05832	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (511 aa)
	DLAC_05845	Enoyl-CoA hydratase/isomerase domain-containing protein; Belongs to the enoyl-CoA hydratase/isomerase family. (299 aa)
	DLAC_05688	Uncharacterized protein. (427 aa)
	DLAC_11632	Uncharacterized protein. (688 aa)
	DLAC_06749	SET domain-containing protein. (635 aa)
	DLAC_06754	Isovaleryl-CoA dehydrogenase. (413 aa)
	DLAC_06573	SET domain-containing protein. (1243 aa)
	DLAC_06463	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (420 aa)
	DLAC_06331	Dihydrolipoyl dehydrogenase. (489 aa)
	DLAC_07036	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (467 aa)
	DLAC_06908	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (318 aa)
	DLAC_06907	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (407 aa)
	DLAC_07180	3-methyl-2-oxobutanoate dehydrogenase. (371 aa)
	DLAC_07379	SET domain-containing protein. (481 aa)
	DLAC_08293	Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (420 aa)
	DLAC_08029	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (466 aa)
	DLAC_07894	Methylmalonate-semialdehyde dehydrogenase (Acylating). (526 aa)
	DLAC_09422	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (431 aa)
	DLAC_09088	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (510 aa)
	DLAC_09042	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (396 aa)
	DLAC_08999	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (299 aa)
	DLAC_08513	Hydroxymethylglutaryl-CoA lyase. (409 aa)
	DLAC_09993	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (280 aa)
	DLAC_11797	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (497 aa)
	DLAC_10209	Acyl-Coenzyme A dehydrogenase. (428 aa)
	DLAC_10681	3-hydroxyisobutyrate dehydrogenase. (304 aa)
	DLAC_11356	SET domain-containing protein. (438 aa)
	DLAC_11825	Uncharacterized protein. (532 aa)
	DLAC_10963	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (302 aa)

Your Current Organism:

Tieghemostelium lacteum

NCBI taxonomy Id: 361077
Other names: Dictyostelium lacteum, T. lacteum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLAC_00166	DLAC_03181	A0A152A9A0	A0A152A2V0	Methylmalonyl-coenzyme A mutase.	Propionyl-CoA carboxylase.	0.756
DLAC_00166	DLAC_05006	A0A152A9A0	A0A151ZIF1	Methylmalonyl-coenzyme A mutase.	Methylmalonyl-CoA epimerase.	0.998
DLAC_01220	DLAC_01917	A0A152A819	A0A152A5B8	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.751
DLAC_01220	DLAC_02486	A0A152A819	A0A152A2P7	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Propionyl-CoA carboxylase.	0.497
DLAC_01220	DLAC_03181	A0A152A819	A0A152A2V0	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Propionyl-CoA carboxylase.	0.494
DLAC_01220	DLAC_03310	A0A152A819	A0A152A212	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.751
DLAC_01220	DLAC_03436	A0A152A819	A0A152A1Z3	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	SH2 domain-containing protein.	0.497
DLAC_01220	DLAC_03770	A0A152A819	A0A152A0P0	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Transmembrane protein.	0.497
DLAC_01220	DLAC_05006	A0A152A819	A0A151ZIF1	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Methylmalonyl-CoA epimerase.	0.401
DLAC_01220	DLAC_06463	A0A152A819	A0A151ZEY8	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.751
DLAC_01220	DLAC_06754	A0A152A819	A0A151ZFJ6	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Isovaleryl-CoA dehydrogenase.	0.626
DLAC_01220	DLAC_07036	A0A152A819	A0A151ZE52	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.461
DLAC_01220	DLAC_07894	A0A152A819	A0A151ZAN8	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Methylmalonate-semialdehyde dehydrogenase (Acylating).	0.513
DLAC_01220	DLAC_08029	A0A152A819	A0A151ZAZ2	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.461
DLAC_01220	DLAC_08293	A0A152A819	A0A151ZBT1	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.751
DLAC_01220	DLAC_08513	A0A152A819	A0A151Z7K2	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Hydroxymethylglutaryl-CoA lyase.	0.576
DLAC_01220	DLAC_08999	A0A152A819	A0A151Z8V1	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.989
DLAC_01220	DLAC_09784	A0A152A819	A0A151Z774	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.	0.560
DLAC_01220	DLAC_10209	A0A152A819	A0A151Z4U6	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Acyl-Coenzyme A dehydrogenase.	0.625
DLAC_01220	DLAC_10681	A0A152A819	A0A151Z4H3	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	3-hydroxyisobutyrate dehydrogenase.	0.996