(34 nodes) Terpenoid backbone biosynthesis network (Tieghemostelium lacteum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	DLAC_08961	Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (358 aa)
	DLAC_05344	Protein prenyltransferase alpha subunit. (326 aa)
	DLAC_07036	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (467 aa)
	DLAC_07021	Mevalonate kinase. (385 aa)
	DLAC_06969	Uncharacterized protein. (263 aa)
	DLAC_08395	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (392 aa)
	DLAC_08293	Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (420 aa)
	DLAC_08010	Protein-S-isoprenylcysteine O-methyltransferase. (237 aa)
	DLAC_08029	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (466 aa)
	DLAC_10384	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (441 aa)
	DLAC_10433	Uncharacterized protein. (509 aa)
	DLAC_10736	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (824 aa)
	DLAC_11190	3-hydroxy-3-methylglutaryl coenzyme A reductase. (539 aa)
	DLAC_10965	Uncharacterized protein. (345 aa)
	DLAC_10887	Uncharacterized protein. (290 aa)
	DLAC_00092	Alkyl transferase; Belongs to the UPP synthase family. (317 aa)
	DLAC_00869	Uncharacterized protein. (903 aa)
	DLAC_01891	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (428 aa)
	DLAC_01917	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
	DLAC_02163	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (337 aa)
	DLAC_02574	Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (382 aa)
	DLAC_11525	AA_kinase domain-containing protein. (295 aa)
	DLAC_03149	Trans-prenyltransferase; Belongs to the FPP/GGPP synthase family. (458 aa)
	DLAC_03104	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (298 aa)
	DLAC_03310	Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (418 aa)
	DLAC_03721	Uncharacterized protein. (500 aa)
	DLAC_03718	Isopentenyl-diphosphate D-isomerase. (251 aa)
	DLAC_04301	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (452 aa)
	DLAC_04868	3-hydroxy-3-methylglutaryl coenzyme A reductase. (541 aa)
	DLAC_05221	Uncharacterized protein. (338 aa)
	DLAC_05176	Prenylcys_lyase domain-containing protein. (519 aa)
	DLAC_06137	Peptidase_M48 domain-containing protein. (453 aa)
	DLAC_05970	Putative transmembrane protein. (373 aa)
	DLAC_05826	Uncharacterized protein. (873 aa)

Your Current Organism:

Tieghemostelium lacteum

NCBI taxonomy Id: 361077
Other names: Dictyostelium lacteum, T. lacteum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLAC_00092	DLAC_02574	A0A152A8U5	A0A152A2T7	Alkyl transferase; Belongs to the UPP synthase family.	Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family.	0.875
DLAC_00092	DLAC_03104	A0A152A8U5	A0A152A290	Alkyl transferase; Belongs to the UPP synthase family.	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family.	0.989
DLAC_00092	DLAC_03149	A0A152A8U5	A0A152A2D2	Alkyl transferase; Belongs to the UPP synthase family.	Trans-prenyltransferase; Belongs to the FPP/GGPP synthase family.	0.945
DLAC_00092	DLAC_03718	A0A152A8U5	A0A152A0P2	Alkyl transferase; Belongs to the UPP synthase family.	Isopentenyl-diphosphate D-isomerase.	0.802
DLAC_00092	DLAC_05221	A0A152A8U5	A0A151ZIK5	Alkyl transferase; Belongs to the UPP synthase family.	Uncharacterized protein.	0.497
DLAC_00092	DLAC_05344	A0A152A8U5	A0A151ZFR2	Alkyl transferase; Belongs to the UPP synthase family.	Protein prenyltransferase alpha subunit.	0.993
DLAC_00092	DLAC_05826	A0A152A8U5	A0A151ZH06	Alkyl transferase; Belongs to the UPP synthase family.	Uncharacterized protein.	0.497
DLAC_00092	DLAC_05970	A0A152A8U5	A0A151ZHC0	Alkyl transferase; Belongs to the UPP synthase family.	Putative transmembrane protein.	0.539
DLAC_00092	DLAC_06969	A0A152A8U5	A0A151ZDU5	Alkyl transferase; Belongs to the UPP synthase family.	Uncharacterized protein.	0.999
DLAC_00092	DLAC_07021	A0A152A8U5	A0A151ZDZ5	Alkyl transferase; Belongs to the UPP synthase family.	Mevalonate kinase.	0.491
DLAC_00092	DLAC_08395	A0A152A8U5	A0A151ZBV6	Alkyl transferase; Belongs to the UPP synthase family.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.678
DLAC_00092	DLAC_08961	A0A152A8U5	A0A151Z8S6	Alkyl transferase; Belongs to the UPP synthase family.	Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family.	0.875
DLAC_00092	DLAC_10384	A0A152A8U5	A0A151Z5R6	Alkyl transferase; Belongs to the UPP synthase family.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.993
DLAC_00092	DLAC_10887	A0A152A8U5	A0A151Z2L3	Alkyl transferase; Belongs to the UPP synthase family.	Uncharacterized protein.	0.472
DLAC_00092	DLAC_10965	A0A152A8U5	A0A151Z379	Alkyl transferase; Belongs to the UPP synthase family.	Uncharacterized protein.	0.497
DLAC_01891	DLAC_02163	A0A152A6M7	A0A152A4B7	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.	0.747
DLAC_01891	DLAC_04301	A0A152A6M7	A0A151ZJ50	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.772
DLAC_01891	DLAC_05344	A0A152A6M7	A0A151ZFR2	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	Protein prenyltransferase alpha subunit.	0.996
DLAC_01891	DLAC_08010	A0A152A6M7	A0A151ZB43	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	Protein-S-isoprenylcysteine O-methyltransferase.	0.996
DLAC_01891	DLAC_10384	A0A152A6M7	A0A151Z5R6	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.996